unc-5-like, CT20824, Unc5d
multiple domain protein that functions as a repulsive netrin receptor - essential for heart lumen formation
Please see the JBrowse view of Dmel\unc-5 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Phosphorylated on different cytoplasmic tyrosine residues.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\unc-5 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
At embryonic stage 15 before the cardiomyocytes from the bilateral primordia meet at the dorsal midline, unc-5 is localized to these cells in a polarized fashion. Strong signal is observed on the prospective lumen forming side and a slightly weaker signal is seen at the opposite membrane region. Essentially no proteinis detected on the lateral sides of cardiomyocytes.
JBrowse - Visual display of RNA-Seq signals
View Dmel\unc-5 in JBrowse2-74
2-78.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
The growth cone response (repulsive) is determined by the cytoplasmic domain of unc-5.
Source for identity of unc-5 CG8166 CG8168 was sequence comparison ( date:000607 ).
Source for identity of: unc-5 CG8166 CG8168