FB2024_03 , released June 25, 2024
Allele: Dmel\unc-52
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General Information
Symbol
Dmel\unc-52
Species
D. melanogaster
Name
FlyBase ID
FBal0193805
Feature type
allele
Associated gene
Dmel\unc-5
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Labrador, 2005)
Mutagen
ethyl methanesulfonate
(Labrador, 2005)
Progenitor genotype
Cytology
Description

Frameshift at T223 and the stop codon.

(Labrador, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      24% of unc-52 mutants and 19% of unc-58/unc-52 transheterozygotes show a SNa guidance phenotype.

      (Labrador, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      unc-5[+]/unc-52 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4eg-Mz360, fraΔC.UAS.Tag:HA

      (O'Donnell and Bashaw, 2013)
      NOT Enhancer of
      Statement
      Reference

      unc-5[+]/unc-52 is a non-enhancer of abnormal neuroanatomy phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)
      NOT Suppressor of
      Statement
      Reference

      unc-5[+]/unc-52 is a non-suppressor of abnormal neuroanatomy phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      unc-5[+]/unc-52 is a non-enhancer of larval EW neuron phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)

      unc-5[+]/unc-52 is a non-enhancer of larval posterior commissure phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)

      unc-5[+]/unc-52 is a non-enhancer of larval longitudinal connective phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)
      NOT Suppressor of
      Statement
      Reference

      unc-5[+]/unc-52 is a non-suppressor of larval EW neuron phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)

      unc-5[+]/unc-52 is a non-suppressor of larval posterior commissure phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)

      unc-5[+]/unc-52 is a non-suppressor of larval longitudinal connective phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      An unc-52 heterozygous background does not affect the level EW axon midline crossing defects found in fra3/fra6 hypomorphic mutants.

      A unc-52 heterozygous background increases the percentage of embryonic segments displaying eg-positive axon midline crossing defects in flies expressing fraΔC.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4eg-Mz360. However, this increase isn't considered statistically significant.

      (O'Donnell and Bashaw, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      unc-58/unc-52 is partially rescued by unc-5UAS.Tag:HA,Tag:SS(wg)/Scer\GAL4elav.PLu

      (Labrador, 2005)
      Comments

      Expression of unc-5Scer\UAS.T:Ivir\HA1,T:wg, under the control of Scer\GAL4elav.PLu, partially rescues the ISN and SNa defects of unc-52/unc-58 mutants.

      (Labrador, 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a suppressor of the unc-5GS; Scer\GAL4scrt-GAL4 lethal phenotype.

      (Labrador, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Unc-52
      (Labrador, 2005)
      unc-52
      (O'Donnell and Bashaw, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)