hdc, l(3)B4-3-20, Fusion-6, psg12
novel basic protein - expression prefigures the mitotic activation of imaginal tissue proliferation - regulates tracheal branching
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.47
Gene model reviewed during 5.44
Stop-codon suppression (UAA) postulated; FBrf0101899; protein extension supported (FBrf0223513.
Stop-codon suppression supported by data in FBrf0216884.
Gene model reviewed during 5.55
4.5 (northern blot)
4.6 (compiled cDNA)
1080 (aa); 125 (kD predicted)
649 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\heca using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: from -12 hr APF
Comment: peak at P4
hdc shows a gradual increase in expression after puparium formation in salivary glands and in whole animals, with a spike in expression immediately after head eversion in salivary glands.
hdc transcripts are observed in the CNS, in imaginal disc primordia, and in imaginal tracheal cells of the spiracular branch.
The embryonic and larval pattern ofhdc transcript expression matches that of a hdcFBtr0091350:pb-XREcollacZ enhancer trap(EcollacZhdc-B5). hdc is expressed in all imaginal cells.
Comment: both termination and read-through isoforms
Comment: termination isoform only
JBrowse - Visual display of RNA-Seq signals
View Dmel\heca in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
hdc is a branching inhibitor produced by specialised tracheal cells to prevent neighbouring cells from branching.
In mutants, cells that are normally quiescent acquire the branching fate and form an increased number of sprouts emanating from the primary branches.
Cellular, molecular and genetic characterisation of hdc, which is required for imaginal cell development. Imaginal disc morphology in null mutants appears normal, so loss of hdc expression does not affect imaginal cell growth but instead interferes with the ability of the imaginal primordia to differentiate properly during pupal development. These results suggest hdc may be involved in hormonal responsiveness during metamorphosis.
Recessive pupal lethal: head structure abnormal.
Source for merge of: hdc l(3)B4-3-20
Source for identity of: heca hdc
Changed gene symbol 'hdc' to 'heca' (the symbol used for vertebrate orthologs) to eliminate the case-insensitive duplication with the 'Hdc' gene symbol, which is the widely used abbreviation for the gene encoding histidine decarboxylase across species.
