dTsc1, TSC, tuberous sclerosis complex 1, rocky
acts in conjunction with TSC2 to suppress cell growth by inhibiting Tor, a central controller of cell growth - TSC1/TSC2 has GAP activity toward the Rheb small GTPase which acts upstream of and stimulates TOR - TSC2 is the catalytic GAP subunit, while TSC1 enhances TSC2 function by stabilizing TSC2
Please see the JBrowse view of Dmel\Tsc1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
3.8 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
1100 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsc1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Tsc1 in JBrowse3-83
3-82.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Tsc1 controls the timing of differentiation in the developing eye.
Tsc1 is a negative regulator of insulin signalling.
Cells mutant for Tsc1 are dramatically increased in size yet differentiate normally.
Mutations in Tsc1 result in enhanced growth and cell size with no change in ploidy. Overall, mutant cells spend less time in G1.
Cells in mutant clones are significantly larger than their wild-type neighbours and contain larger nuclei.
Source for merge of: Tsc1 rocky
Source for identity of: Tsc1 CG6147
