FB2024_04 , released June 25, 2024
FB2024_04 , released June 25, 2024
CV Term Report
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General Information
Term signal transduction ID (Ontology) GO:0007165 (Gene Ontology)
Definition The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     165
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 signal transduction (all annotations which use CV term, excluding "NOT" statements)       1    165
     involved_in | signal transduction       --     165
Spanning Tree (Parents/Children)
Only view relationship: 
biological_process
 |__cellular process________________
cellular process                    |
 |__cell communication______________|
 |__regulation of cellular process__|
 |__cellular response to stimulus___|
regulation of biological process    |
 |__signaling_______________________|
 |__regulation of cellular process__|
response to stimulus                |
 |__cellular response to stimulus___|
                                    signal transduction  1677 rec.
                                     |__apoptotic signaling pathway 62 rec.
                                     |   |__apoptosome assembly(+)
                                     |   |__extrinsic apoptotic signaling pathway(+) 10 rec.
                                     |   |__granzyme-mediated apoptotic signaling pathway
                                     |   |__hormone-mediated apoptotic signaling pathway
                                     |   |__intrinsic apoptotic signaling pathway(+) 27 rec.
                                     |   |__mitochondrial outer membrane permeabilization(+) 5 rec.
                                     |   |__regulation of apoptotic signaling pathway(+) 33 rec.
                                     |   |__release of cytochrome c from mitochondria(+) 5 rec.
                                     |__bile acid signaling pathway
                                     |   |__cell surface bile acid receptor signaling pathway
                                     |   |__intracellular bile acid receptor signaling pathway
                                     |__calmodulin dependent kinase signaling pathway
                                     |   |__CAMKK-AMPK signaling cascade(+)
                                     |__carbohydrate mediated signaling
                                     |   |__sugar mediated signaling pathway(+)
                                     |__cell surface receptor signaling pathway 789 rec.
                                     |   |__apolipoprotein A-I-mediated signaling pathway(+)
                                     |   |__CD27 signaling pathway
                                     |   |__CD40 signaling pathway(+)
                                     |   |__cell surface bile acid receptor signaling pathway
                                     |   |__cell surface receptor signaling pathway involved in heart development(+)
                                     |   |__cell surface receptor signaling pathway via STAT(+) 47 rec.
                                     |   |__chemical synaptic transmission, postsynaptic(+) 4 rec.
                                     |   |__collagen-activated signaling pathway(+)
                                     |   |__cytokine-mediated signaling pathway(+) 34 rec.
                                     |   |__enzyme-linked receptor protein signaling pathway(+) 340 rec.
                                     |   |__extrinsic apoptotic signaling pathway(+) 10 rec.
                                     |   |__Fas signaling pathway(+)
                                     |   |__glutamate receptor signaling pathway(+) 6 rec.
                                     |   |__immune response-regulating cell surface receptor signaling pathway(+) 2 rec.
                                     |   |__integrin-mediated signaling pathway(+) 15 rec.
                                     |   |__lipopolysaccharide-mediated signaling pathway(+) 1 rec.
                                     |   |__netrin-activated signaling pathway(+) 3 rec.
                                     |   |__neuropilin signaling pathway(+)
                                     |   |__neurotrophin signaling pathway(+) 1 rec.
                                     |   |__Norrin signaling pathway
                                     |   |__Notch signaling pathway(+) 101 rec.
                                     |   |__positive regulation of integrin activation by cell surface receptor linked signal transduction
                                     |   |__purinergic nucleotide receptor signaling pathway(+) 2 rec.
                                     |   |__reelin-mediated signaling pathway
                                     |   |__Roundabout signaling pathway(+) 6 rec.
                                     |   |__semaphorin-plexin signaling pathway(+) 11 rec.
                                     |   |__smoothened signaling pathway(+) 102 rec.
                                     |   |__Toll signaling pathway(+) 55 rec.
                                     |   |__urokinase plasminogen activator signaling pathway
                                     |   |__Wnt signaling pathway(+) 143 rec.
                                     |__chloroplast-nucleus signaling pathway
                                     |__dopamine receptor signaling pathway 9 rec.
                                     |   |__adenylate cyclase-activating dopamine receptor signaling pathway 4 rec.
                                     |   |__adenylate cyclase-inhibiting dopamine receptor signaling pathway(+)
                                     |   |__phospholipase C-activating dopamine receptor signaling pathway 1 rec.
                                     |   |__regulation of dopamine receptor signaling pathway(+) 1 rec.
                                     |__endoplasmic reticulum unfolded protein response 19 rec.
                                     |   |__ATF6-mediated unfolded protein response(+)
                                     |   |__IRE1-mediated unfolded protein response(+) 2 rec.
                                     |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                     |   |__regulation of endoplasmic reticulum unfolded protein response(+) 1 rec.
                                     |__ER-nucleus signaling pathway 7 rec.
                                     |   |__ATF6-mediated unfolded protein response(+)
                                     |   |__ER overload response(+)
                                     |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                     |   |__SREBP signaling pathway(+) 5 rec.
                                     |__extracellular ATP signaling
                                     |__G protein-coupled receptor signaling pathway 262 rec.
                                     |   |__adenylate cyclase-modulating G protein-coupled receptor signaling pathway(+) 64 rec.
                                     |   |__adrenergic receptor signaling pathway(+) 11 rec.
                                     |   |__angiotensin-activated signaling pathway(+) 1 rec.
                                     |   |__apelin receptor signaling pathway
                                     |   |__bombesin receptor signaling pathway
                                     |   |__calcitonin family receptor signaling pathway(+)
                                     |   |__cannabinoid signaling pathway(+)
                                     |   |__chemokine-mediated signaling pathway(+)
                                     |   |__cholecystokinin signaling pathway(+)
                                     |   |__complement component C5a signaling pathway
                                     |   |__endothelin receptor signaling pathway(+)
                                     |   |__follicle-stimulating hormone signaling pathway
                                     |   |__G protein-coupled acetylcholine receptor signaling pathway(+) 4 rec.
                                     |   |__G protein-coupled chemorepellent receptor signaling pathway
                                     |   |__G protein-coupled glutamate receptor signaling pathway(+) 3 rec.
                                     |   |__G protein-coupled opioid receptor signaling pathway(+)
                                     |   |__G protein-coupled purinergic receptor signaling pathway(+) 2 rec.
                                     |   |__G protein-coupled receptor signaling pathway involved in dauer larval development
                                     |   |__G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium
                                     |   |__G protein-coupled receptor signaling pathway involved in heart process(+)
                                     |   |__G protein-coupled receptor signaling pathway involved in social behavior 1 rec.
                                     |   |__G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(+) 9 rec.
                                     |   |__G protein-coupled serotonin receptor signaling pathway(+) 2 rec.
                                     |   |__gastric inhibitory peptide signaling pathway
                                     |   |__ion channel modulating, G protein-coupled receptor signaling pathway(+)
                                     |   |__leukotriene signaling pathway
                                     |   |__luteinizing hormone signaling pathway(+)
                                     |   |__neuropeptide signaling pathway(+) 58 rec.
                                     |   |__octopamine or tyramine signaling pathway(+) 10 rec.
                                     |   |__phospholipase C-activating G protein-coupled receptor signaling pathway(+) 18 rec.
                                     |   |__phospholipase C-inhibiting G protein-coupled receptor signaling pathway 1 rec.
                                     |   |__phospholipase D-activating G protein-coupled receptor signaling pathway
                                     |   |__protein kinase C-activating G protein-coupled receptor signaling pathway 5 rec.
                                     |   |__regulation of G protein-coupled receptor signaling pathway(+) 35 rec.
                                     |   |__rhodopsin mediated signaling pathway(+) 22 rec.
                                     |   |__somatostatin receptor signaling pathway(+)
                                     |   |__sphingosine-1-phosphate receptor signaling pathway
                                     |   |__tachykinin receptor signaling pathway(+) 4 rec.
                                     |   |__thrombin-activated receptor signaling pathway(+)
                                     |   |__thromboxane A2 signaling pathway
                                     |   |__thyroid-stimulating hormone signaling pathway
                                     |__granzyme-mediated programmed cell death signaling pathway
                                     |   |__granzyme-mediated apoptotic signaling pathway
                                     |__hormone-mediated signaling pathway 31 rec.
                                     |   |__abscisic acid-activated signaling pathway(+)
                                     |   |__adiponectin-activated signaling pathway 1 rec.
                                     |   |__auxin-activated signaling pathway(+)
                                     |   |__cytokinin-activated signaling pathway(+)
                                     |   |__ethylene-activated signaling pathway(+)
                                     |   |__gibberellin mediated signaling pathway(+)
                                     |   |__hormone-mediated apoptotic signaling pathway
                                     |   |__jasmonic acid mediated signaling pathway(+)
                                     |   |__juvenile hormone mediated signaling pathway 5 rec.
                                     |   |__prolactin signaling pathway(+)
                                     |   |__somatostatin signaling pathway
                                     |   |__steroid hormone mediated signaling pathway(+) 15 rec.
                                     |   |__thyroid hormone mediated signaling pathway(+)
                                     |__hydrogen peroxide mediated signaling pathway 3 rec.
                                     |   |__hydrogen peroxide mediated signaling pathway involved in stomatal movement
                                     |   |__positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway
                                     |__hypoxia-inducible factor-1alpha signaling pathway
                                     |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                     |__immune response-regulating signaling pathway 97 rec.
                                     |   |__immune response-activating signaling pathway(+) 97 rec.
                                     |   |__immune response-inhibiting signal transduction(+)
                                     |   |__immune response-regulating cell surface receptor signaling pathway(+) 2 rec.
                                     |__intracellular receptor signaling pathway 29 rec.
                                     |   |__blue light signaling pathway 1 rec.
                                     |   |__cytoplasmic pattern recognition receptor signaling pathway(+) 9 rec.
                                     |   |__intracellular bile acid receptor signaling pathway
                                     |   |__juvenile hormone mediated signaling pathway 5 rec.
                                     |   |__nuclear receptor signaling pathway(+) 14 rec.
                                     |   |__peroxisome proliferator activated receptor signaling pathway(+)
                                     |   |__retinoic acid receptor signaling pathway(+)
                                     |   |__thyroid hormone mediated signaling pathway(+)
                                     |   |__vitamin D receptor signaling pathway(+)
                                     |__intracellular signal transduction 703 rec.
                                     |   |__cell cycle checkpoint signaling(+) 59 rec.
                                     |   |__hippo signaling(+) 97 rec.
                                     |   |__intracellular signaling cassette(+) 430 rec.
                                     |   |__intrinsic apoptotic signaling pathway(+) 27 rec.
                                     |   |__osmosensory signaling pathway(+)
                                     |   |__phosphatidylinositol-mediated signaling 8 rec.
                                     |   |__phosphorelay signal transduction system(+)
                                     |   |__protein kinase A signaling(+) 10 rec.
                                     |   |__protein kinase C signaling(+) 2 rec.
                                     |   |__RAM/MOR signaling
                                     |   |__regulation of intracellular signal transduction(+) 410 rec.
                                     |   |__signal transduction by p53 class mediator(+) 10 rec.
                                     |   |__signal transduction in response to DNA damage(+) 41 rec.
                                     |   |__stress-activated protein kinase signaling cascade(+) 7 rec.
                                     |   |__TOR signaling(+) 74 rec.
                                     |__ligand-gated ion channel signaling pathway 3 rec.
                                     |   |__ionotropic glutamate receptor signaling pathway(+) 3 rec.
                                     |   |__serotonin-gated cation-selective signaling pathway
                                     |__lipoprotein particle mediated signaling
                                     |   |__high density lipoprotein particle mediated signaling
                                     |   |__low-density lipoprotein particle mediated signaling
                                     |__mitochondria-nucleus signaling pathway
                                     |__necroptotic signaling pathway
                                     |__neuronal signal transduction 4 rec.
                                     |   |__regulation of neuronal signal transduction(+) 1 rec.
                                     |__opioid growth factor receptor signaling pathway
                                     |__phototransduction 61 rec.
                                     |   |__G protein-mediated opsin signaling pathway(+) 6 rec.
                                     |   |__phototransduction, UV 5 rec.
                                     |   |__phototransduction, visible light(+) 29 rec.
                                     |   |__red, far-red light phototransduction
                                     |   |__rhodopsin mediated signaling pathway(+) 22 rec.
                                     |   |__UV-A, blue light phototransduction 2 rec.
                                     |__postsynaptic signal transduction 4 rec.
                                     |   |__acetylcholine receptor signaling pathway(+) 4 rec.
                                     |   |__postsynapse to nucleus signaling pathway(+)
                                     |__presynaptic signal transduction
                                     |   |__presynapse to nucleus signaling pathway
                                     |__red or far-red light signaling pathway
                                     |   |__far-red light signaling pathway
                                     |   |__red light signaling pathway
                                     |   |__red, far-red light phototransduction
                                     |   |__regulation of red or far-red light signaling pathway(+)
                                     |__regulation of blood pressure by chemoreceptor signaling pathway
                                     |__regulation of floral organ abscission by signal transduction
                                     |__regulation of signal transduction 899 rec.
                                     |   |__adaptation of signaling pathway(+) 4 rec.
                                     |   |__extracellular regulation of signal transduction(+) 3 rec.
                                     |   |__modulation of excitatory postsynaptic potential(+) 1 rec.
                                     |   |__modulation of inhibitory postsynaptic potential(+)
                                     |   |__negative regulation of signal transduction(+) 443 rec.
                                     |   |__positive regulation of signal transduction(+) 478 rec.
                                     |   |__regulation of abscisic acid-activated signaling pathway(+)
                                     |   |__regulation of antigen receptor-mediated signaling pathway(+)
                                     |   |__regulation of apolipoprotein A-I-mediated signaling pathway(+)
                                     |   |__regulation of apoptotic signaling pathway(+) 33 rec.
                                     |   |__regulation of auxin mediated signaling pathway(+)
                                     |   |__regulation of brain-derived neurotrophic factor receptor signaling pathway(+)
                                     |   |__regulation of brassinosteroid mediated signaling pathway(+)
                                     |   |__regulation of CD40 signaling pathway(+)
                                     |   |__regulation of cytokine-mediated signaling pathway(+) 14 rec.
                                     |   |__regulation of cytokinin-activated signaling pathway(+)
                                     |   |__regulation of dopamine receptor signaling pathway(+) 1 rec.
                                     |   |__regulation of endoplasmic reticulum unfolded protein response(+) 1 rec.
                                     |   |__regulation of ephrin receptor signaling pathway(+)
                                     |   |__regulation of ERBB signaling pathway(+) 57 rec.
                                     |   |__regulation of Fas signaling pathway(+)
                                     |   |__regulation of Fc receptor mediated stimulatory signaling pathway(+)
                                     |   |__regulation of fibroblast growth factor receptor signaling pathway(+) 14 rec.
                                     |   |__regulation of G protein-coupled receptor signaling pathway(+) 35 rec.
                                     |   |__regulation of gibberellic acid mediated signaling pathway(+)
                                     |   |__regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation(+)
                                     |   |__regulation of glucocorticoid mediated signaling pathway(+)
                                     |   |__regulation of glucose mediated signaling pathway(+)
                                     |   |__regulation of glutamate receptor signaling pathway(+)
                                     |   |__regulation of growth hormone receptor signaling pathway(+)
                                     |   |__regulation of hepatocyte growth factor receptor signaling pathway(+)
                                     |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                     |   |__regulation of insulin receptor signaling pathway(+) 54 rec.
                                     |   |__regulation of insulin-like growth factor receptor signaling pathway(+) 3 rec.
                                     |   |__regulation of integrin-mediated signaling pathway(+) 3 rec.
                                     |   |__regulation of intracellular signal transduction(+) 410 rec.
                                     |   |__regulation of intracellular steroid hormone receptor signaling pathway(+) 10 rec.
                                     |   |__regulation of jasmonic acid mediated signaling pathway
                                     |   |__regulation of lipopolysaccharide-mediated signaling pathway(+)
                                     |   |__regulation of netrin-activated signaling pathway(+) 1 rec.
                                     |   |__regulation of neuronal signal transduction(+) 1 rec.
                                     |   |__regulation of neurotrophin TRK receptor signaling pathway(+)
                                     |   |__regulation of Notch signaling pathway(+) 85 rec.
                                     |   |__regulation of pattern recognition receptor signaling pathway(+) 66 rec.
                                     |   |__regulation of peroxisome proliferator activated receptor signaling pathway(+)
                                     |   |__regulation of platelet-derived growth factor receptor signaling pathway(+)
                                     |   |__regulation of postsynapse to nucleus signaling pathway
                                     |   |__regulation of receptor signaling pathway via STAT(+) 39 rec.
                                     |   |__regulation of red or far-red light signaling pathway(+)
                                     |   |__regulation of retinoic acid receptor signaling pathway(+)
                                     |   |__regulation of Roundabout signaling pathway(+) 1 rec.
                                     |   |__regulation of salicylic acid mediated signaling pathway(+)
                                     |   |__regulation of semaphorin-plexin signaling pathway(+) 2 rec.
                                     |   |__regulation of sevenless signaling pathway(+) 15 rec.
                                     |   |__regulation of signal transduction by receptor internalization(+) 1 rec.
                                     |   |__regulation of signal transduction involved in conjugation with cellular fusion(+)
                                     |   |__regulation of signaling receptor activity(+)
                                     |   |__regulation of smoothened signaling pathway(+) 94 rec.
                                     |   |__regulation of sphingolipid mediated signaling pathway(+)
                                     |   |__regulation of SREBP signaling pathway(+) 1 rec.
                                     |   |__regulation of thyroid hormone mediated signaling pathway(+)
                                     |   |__regulation of Toll signaling pathway(+) 42 rec.
                                     |   |__regulation of torso signaling pathway(+) 11 rec.
                                     |   |__regulation of transmembrane receptor protein serine/threonine kinase signaling pathway(+) 68 rec.
                                     |   |__regulation of vascular endothelial growth factor receptor signaling pathway(+) 10 rec.
                                     |   |__regulation of vascular endothelial growth factor signaling pathway(+)
                                     |   |__regulation of vitamin D receptor signaling pathway(+)
                                     |   |__regulation of Wnt signaling pathway(+) 115 rec.
                                     |   |__signal clustering
                                     |   |__signal complex assembly 1 rec.
                                     |__salicylic acid mediated signaling pathway
                                     |   |__regulation of salicylic acid mediated signaling pathway(+)
                                     |   |__systemic acquired resistance, salicylic acid mediated signaling pathway(+)
                                     |__serotonin receptor signaling pathway 6 rec.
                                     |   |__adenylate cyclase-activating serotonin receptor signaling pathway 1 rec.
                                     |   |__positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway
                                     |   |__serotonin-gated cation-selective signaling pathway
                                     |__signal transduction in absence of ligand 3 rec.
                                     |   |__extrinsic apoptotic signaling pathway in absence of ligand(+) 3 rec.
                                     |   |__ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway
                                     |__signal transduction involved in cellular response to ammonium ion
                                     |__signal transduction involved in filamentous growth
                                     |__signal transduction involved in positive regulation of conjugation with cellular fusion
                                     |   |__pheromone-dependent signal transduction involved in conjugation with cellular fusion(+)
                                     |   |__regulation of signal transduction involved in conjugation with cellular fusion(+)
                                     |__signal transduction involved in regulation of gene expression
                                     |__sphingolipid mediated signaling pathway
                                         |__regulation of sphingolipid mediated signaling pathway(+)
                                         |__sphingosine-1-phosphate receptor signaling pathway
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Is a cellular process
regulation of cellular process
Part of cell communication
signaling
cellular response to stimulus
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Synonyms
  • "signaling cascade" NARROW
    "signaling pathway" RELATED
    "signalling cascade" NARROW
    "signalling pathway" RELATED
Secondary IDs
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Wikipedia:Signal_transduction