Gene Group: INTRACELLULAR TRANSPORT COAT, SCAFFOLD AND ADAPTOR PROTEINS

General Information

Name

INTRACELLULAR TRANSPORT COAT, SCAFFOLD AND ADAPTOR PROTEINS

Species

D. melanogaster

Symbol

ITCSAP

FlyBase ID

FBgg0000056

Date last reviewed

2013-02-03

Number of members

Description

Complexes and proteins that act as scaffolds, coats or adaptors in vesicle-mediated transport.

Notes on Group

Source Material

The INTRACELLULAR TRANSPORT COAT, SCAFFOLD AND ADAPTOR PROTEINS Gene Group has been compiled using the following publication(s): Cai et al., 2016, Wei et al., 2016, Li and Blissard, 2015, Maruzs et al., 2015, Iyer et al., 2013, van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Capalbo et al., 2012, Kitazawa et al., 2012, Dokudovskaya et al., 2011, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011, Michelet et al., 2010, Phillips et al., 2010, Vaccari et al., 2009, Beller et al., 2008, Rodal and Littleton, 2008, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004, Boehm, 2001, and Boehm and Bonifacino, 2001 .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

vesicle-mediated transport

Cellular Component

Related Gene Groups

Component group(s)

ADAPTOR PROTEIN COMPLEXES

CLATHRIN COMPLEX

COAT PROTEIN COMPLEX I

COAT PROTEIN COMPLEX II

ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT

GATOR COMPLEXES

GOLGI-LOCALIZING, GAMMA-ADAPTIN EAR DOMAIN HOMOLOGY, ARF-BINDING PROTEINS

INTRAFLAGELLAR TRANSPORT COMPLEXES

RETROMER

STONINS

Members (85)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ADAPTOR PROTEIN COMPLEX 1

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AP-1-2β

Adaptor Protein complex 1/2, β subunit

Bap, β-adaptin, AP-2β, BAD1, AP-1-2-beta

(Boehm, 2001, Boehm and Bonifacino, 2001)

AP-1γ

Adaptor Protein complex 1, γ subunit

AP1γ, apl4, AP-1^γ

(Boehm, 2001, Boehm and Bonifacino, 2001)

AP-1μ

Adaptor Protein complex 1, μ subunit

AP-47, AP47, μ1, AP-1μ1, apm1

(Boehm, 2001, Boehm and Bonifacino, 2001)

AP-1σ

Adaptor Protein complex 1, σ subunit

σ1, aps1

(Boehm, 2001, Boehm and Bonifacino, 2001)

ADAPTOR PROTEIN COMPLEX 2

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AP-1-2β

Adaptor Protein complex 1/2, β subunit

Bap, β-adaptin, AP-2β, BAD1, AP-1-2-beta

(Boehm, 2001, Boehm and Bonifacino, 2001)

AP-2α

Adaptor Protein complex 2, α subunit

α-adaptin, alpha-Adaptin, α-Ada, ada, AP2α

(Boehm, 2001, Boehm and Bonifacino, 2001)

AP-2μ

Adaptor Protein complex 2, μ subunit

AP-50, AP50, μ2, apm4, MENE(3R)-D

(Boehm, 2001, Boehm and Bonifacino, 2001)

AP-2σ

Adaptor Protein complex 2, σ subunit

σ2, AP-2 sigma, aps2

(Boehm, 2001, Boehm and Bonifacino, 2001)

ADAPTOR PROTEIN COMPLEX 3

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

carmine

μ3, AP-3, apm3, AP3μ3

(Boehm, 2001, Boehm and Bonifacino, 2001)

garnet

AP-3δ, apl5

(Boehm, 2001, Boehm and Bonifacino, 2001)

orange

AP-3σ, σ3, aps3

(Boehm, 2001, Boehm and Bonifacino, 2001)

ruby

beta3, β3, AP-3β, apl6

(Boehm, 2001, Boehm and Bonifacino, 2001)

BBSOME

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Arl6

ADP ribosylation factor-like 6

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

BBIP1

BBSome interacting protein 1

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013)

BBS1

Bardet-Biedl syndrome 1

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

BBS4

Bardet-Biedl syndrome 4

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

BBS5

Bardet-Biedl syndrome 5

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

BBS8

Bardet-Biedl syndrome 8

BBS2

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

BBS9

Bardet-Biedl syndrome 9

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013)

CLATHRIN COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Chc

Clathrin heavy chain

clathrin, l(1)G0438

(Rodal and Littleton, 2008)

Clc

Clathrin light chain

clathrin

(Rodal and Littleton, 2008)

COAT PROTEIN COMPLEX I

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

αCOP

Coat Protein (coatomer) α

α-COP

(Kitazawa et al., 2012, Beller et al., 2008)

β'COP

Coat Protein (coatomer) β'

β'-COP, β'-coatomer protein, beta'-COP

(Beller et al., 2008)

βCOP

Coat Protein (coatomer) β

β-COP

(Kitazawa et al., 2012, Beller et al., 2008)

δCOP

Coat Protein (coatomer) δ

EG:63B12.10, l(1)G0450, l(1)G0301, l(1)G0051, δ-Cop

(Kitazawa et al., 2012, Beller et al., 2008)

εCOP

Coat Protein (coatomer) ε

BcDNA:LD29885

(Beller et al., 2008)

γCOP

Coat Protein (coatomer) γ

copg, l(3)S057302

(Kitazawa et al., 2012, Beller et al., 2008)

ζCOP

Coat Protein (coatomer) ζ

(Kitazawa et al., 2012, Beller et al., 2008)

COAT PROTEIN COMPLEX II

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sar1

Secretion-associated Ras-related 1

l(3)05712, bro5

(Iyer et al., 2013)

Sec13

Secretory 13

l(3)01031

(Iyer et al., 2013)

Sec23

Secretory 23

dSec23p, dSec23, haunted, hau, COPII

(Iyer et al., 2013)

Sec24AB

Secretory 24AB

sec24

(Iyer et al., 2013)

Sec24CD

Secretory 24CD

gho, sten, stenosis, ghost, Sec24

(Iyer et al., 2013)

Sec31

Secretory 31

(Iyer et al., 2013)

ESCRT-0 COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Hrs

Hepatocyte growth factor regulated tyrosine kinase substrate

l(2)23Ad, l(2)23AB5, vps27

(Li and Blissard, 2015, Michelet et al., 2010)

Stam

Signal transducing adaptor molecule

Dstam

(Li and Blissard, 2015, Michelet et al., 2010)

ESCRT-I COMPLEX VPS37A VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mvb12

Multivesicular body subunit 12

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

TSG101

Tumor susceptibility gene 101

ept, erupted, vps23, dTsg101, ESCRT-I

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vps28

Vacuolar protein sorting 28

l(2)k16503, dVps28

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vsp37A

Vacuolar protein sorting 37A

EG:115C2.5, mod(r), modifier of rudimentary

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

ESCRT-I COMPLEX VPS37B VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Mvb12

Multivesicular body subunit 12

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

TSG101

Tumor susceptibility gene 101

ept, erupted, vps23, dTsg101, ESCRT-I

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vps28

Vacuolar protein sorting 28

l(2)k16503, dVps28

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vps37B

Vacuolar protein sorting 37B

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

ESCRT-II COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

lsn

larsen

Vps22

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vps25

Vacuolar protein sorting 25

l(2)44Db, ESCRT-II, l(2)k08904

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vps36

Vacuolar protein sorting 36

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

ESCRT-III COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5498

(Capalbo et al., 2012)

Chmp1

Charged multivesicular body protein 1

(Li and Blissard, 2015, Capalbo et al., 2012, Michelet et al., 2010)

CHMP2B

Charged multivesicular body protein 2b

(Li and Blissard, 2015, Capalbo et al., 2012)

shrb

shrub

Vps32, ESCRT-III, Snf7, vps32/snf7, ESCRT

(Li and Blissard, 2015, Capalbo et al., 2012, Michelet et al., 2010, Vaccari et al., 2009)

Vps2

Vacuolar protein sorting 2

(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)

Vps20

Vacuolar protein sorting 20

(Li and Blissard, 2015, Capalbo et al., 2012, Michelet et al., 2010, Vaccari et al., 2009)

Vps24

Vacuolar protein sorting 24

ESCRT

(Li and Blissard, 2015, Capalbo et al., 2012, Michelet et al., 2010, Vaccari et al., 2009)

Vps60

Vacuolar protein sorting 60

(Li and Blissard, 2015, Capalbo et al., 2012, Michelet et al., 2010)

GATOR1 COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Iml1

Increased minichromosome loss 1

(Cai et al., 2016, Wei et al., 2016, Dokudovskaya et al., 2011)

Nprl2

Nitrogen permease regulator-like 2

(Cai et al., 2016, Wei et al., 2016, Dokudovskaya et al., 2011)

Nprl3

Nitrogen permease regulator-like 3

(Cai et al., 2016, Wei et al., 2016, Dokudovskaya et al., 2011)

GATOR2 COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

mio

missing oocyte

(Cai et al., 2016, Dokudovskaya et al., 2011)

Nup44A

Nucleoporin at 44A

seh1

(Cai et al., 2016, Dokudovskaya et al., 2011)

Sec13

Secretory 13

l(3)01031

(Cai et al., 2016, Dokudovskaya et al., 2011)

Wdr24

WD repeat domain 24

(Cai et al., 2016, Dokudovskaya et al., 2011)

Wdr59

WD repeat domain 59

(Cai et al., 2016, Dokudovskaya et al., 2011)

GOLGI-LOCALIZING, GAMMA-ADAPTIN EAR DOMAIN HOMOLOGY, ARF-BINDING PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Gga

Golgi-localized, γ-adaptin ear containing, ARF binding protein

dGGA

(Boehm, 2001, Boehm and Bonifacino, 2001)

INTRAFLAGELLAR TRANSPORT SUBCOMPLEX-A

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

IFT43

Intraflagellar transport 43

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013)

Oseg1

Outer segment 1

IFT122, mecC

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

Oseg4

Outer segment 4

IFT121

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

Oseg6

Outer segment 6

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

rempA

reduced mechanoreceptor potential A

IFT140, oseg3, remp

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

INTRAFLAGELLAR TRANSPORT SUBCOMPLEX-B

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cluap1

Clusterin associated protein 1

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

IFT20

Intraflagellar transport 20

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

IFT46

Intraflagellar transport 46

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

IFT52

Intraflagellar transport 52

osm-6, osm6

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

IFT54

Intraflagellar transport 54

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

IFT57

Intraflagellar transport 57

che-13, Hippi

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

nompB

no mechanoreceptor potential B

IFT88, osm-5

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

Oseg2

Outer segment 2

osm-1, IFT172

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

Oseg5

Outer segment 5

IFT80

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Jékely and Arendt, 2006, Avidor-Reiss et al., 2004)

Ttc26

Tetratricopeptide repeat domain 26

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

Ttc30

Tetratricopeptide repeat domain 30

(van Dam and Huynen, 2013.11.6, van Dam et al., 2013, Avidor-Reiss et al., 2004)

RETROMER

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Snx1

Sorting nexin 1

Vps5

(Li and Blissard, 2015, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011)

Snx3

Sorting nexin 3

Dsnx3, lincRNA.S6645

(Maruzs et al., 2015, Koumandou et al., 2011, Zhang et al., 2011)

Snx6

Sorting nexin 6

Dsnx6

(Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011)

Vps26

Vacuolar protein sorting 26

EG:63B12.8, dvps26

(Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011)

Vps29

Vacuolar protein sorting 29

(Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011)

Vps35

Vacuolar protein sorting 35

dvps35

(Li and Blissard, 2015, Maruzs et al., 2015, Koumandou et al., 2011, Koumandou et al., 2011, Zhang et al., 2011)

STONINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

stnA

stoned A

stn, stoned, l(1)X-3, X-3, stn-A

(Phillips et al., 2010)

stnB

stoned B

stn, stoned, stn-B

(Phillips et al., 2010, Boehm, 2001, Boehm and Bonifacino, 2001)

VPS4-VTA1 COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Vps4

Vacuolar protein sorting 4

BcDNA:GH02678, dvps4

(Li and Blissard, 2015)

Vta1

Vesicle trafficking 1

(Li and Blissard, 2015, Michelet et al., 2010)

External Data

Equivalent Group(s)

Human Protein coats (HGNC)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

ITCSAP

INTRACELLULAR TRANSPORT COAT, SCAFFOLD AND ADAPTOR PROTEINS

Vesicle coat proteins

Adaptor proteins

Vesicle scaffold proteins

Secondary FlyBase ID(s)

References (23)

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