FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: ESCRT-0 COMPLEX
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General Information
Name
ESCRT-0 COMPLEX
Species
D. melanogaster
Symbol
ESCRT-0
FlyBase ID
FBgg0000052
Date last reviewed
Number of members
2
Description
Description
The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-0 initiates mediates multivesicular body (MVB) formation, binding ubiquitinated membrane proteins destined for degradation and concentrating them in early endosome membranes. ESCRT-0 recruits ESCRT-I. (Adapted from PMID:22361144 and FBrf0209668).
Notes on Group
Source Material
The ESCRT-0 COMPLEX Gene Group has been compiled using the following publication(s): Li and Blissard, 2015 and Michelet et al., 2010 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin binding
Biological Process
endosome transport via multivesicular body sorting pathway
Cellular Component
ESCRT-0 complex
Related Gene Groups
Parent group(s)
ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Hrs
Hepatocyte growth factor regulated tyrosine kinase substrate
l(2)23Ad, l(2)23AB5, vps27
(Li and Blissard, 2015, Michelet et al., 2010)
Stam
Signal transducing adaptor molecule
Dstam
(Li and Blissard, 2015, Michelet et al., 2010)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ESCRT-0
ESCRT-0 COMPLEX
Hrs-STAM complex
Endosomal Sorting Complex Required for Transport 0
ESCRT 0
Secondary FlyBase ID(s)
References (3)