FlyBase Gene Report: Dmel\AP-2μ

General Information

Symbol

Dmel\AP-2μ

Species

D. melanogaster

Name

Adaptor Protein complex 2, μ subunit

Annotation Symbol

CG7057

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263351

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Adaptor Protein complex 2, μ subunit (AP-2μ) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

AP-50, AP50, μ2, apm4, MENE(3R)-D

Key Links

Genomic Location

Cytogenetic map

94A15-94A16

Sequence location

3R:22,462,455..22,464,603 [+]

Recombination map

3-74

RefSeq locus

NT_033777 REGION:22462455..22464603

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables clathrin adaptor activity

inferred from mutant phenotype

(Windler and Bilder, 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables clathrin adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000242371

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in dsRNA transport

inferred from mutant phenotype

(Saleh et al., 2006)

involved_in endocytosis

inferred from mutant phenotype

(Windler and Bilder, 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in clathrin-dependent endocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000242371

(GO Reference Genome Project, 2011-)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR001392, InterPro:IPR018240

(InterPro Project Members, 2004-)

involved_in vesicle-mediated transport

inferred from electronic annotation with InterPro:IPR001392, InterPro:IPR018240

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of AP-2 adaptor complex

inferred from mutant phenotype

(Windler and Bilder, 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of AP-2 adaptor complex

inferred from biological aspect of ancestor with PANTHER:PTN000242371

(GO Reference Genome Project, 2011-)

part_of clathrin adaptor complex

inferred from electronic annotation with InterPro:IPR001392, InterPro:IPR018240

(InterPro Project Members, 2004-)

is_active_in cytoplasmic vesicle

inferred from biological aspect of ancestor with PANTHER:PTN000055849

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ADAPTOR PROTEIN COMPLEX 2

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ADAPTOR PROTEIN COMPLEX 2 -: Adaptor protein (AP) complexes select cargo for inclusion into clathrin coated vesicles in the late secretory and endocytic pathways. AP-2 is involved in plasma membrane to endosome traffic. (Adapted from PMID:10611976 and PMID:15066634).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\AP-2μ for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O62530)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

gene

(Menut et al., 2007)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

AP-2μ-RA

FBtr0084252

NM_170015

1965

437

AP-2μ-RB

FBtr0084253

NM_142792

2025

437

AP-2μ-RC

FBtr0301866

NM_001170215

1976

437

Additional Transcript Data and Comments

Reported size (kB)

1.866 (sequence analysis)

(Mullins et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

AP-2μ-PA

FBpp0083645

49.9

437

10.03

FBpp0083646

49.9

437

10.03

FBpp0291080

49.9

437

10.03

O62530

NP_001163686

ACZ94982

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

437 aa isoforms: AP-2μ-PA, AP-2μ-PB, AP-2μ-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

437 (aa)

(Mullins et al., 1999)

437 (aa); 50 (kD predicted)

(Zhang and Broadie, 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O62530

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AP-2μ using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

AP-2mu_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.59

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 17

embryonic/larval anterior midgut

(Zhang and Broadie, 1999)

embryonic/larval posterior midgut

(Zhang and Broadie, 1999)

embryonic neuroblast

(Zhang and Broadie, 1999)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13

gastric caecum

(Zhang and Broadie, 1999)

embryonic stage 13 -- 16

embryonic/larval garland cell

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 17

embryonic/larval midgut

(Zhang and Broadie, 1999)

presumptive embryonic/larval central nervous system

(Zhang and Broadie, 1999)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Mullins et al., 1999)

Additional Descriptive Data

AP-2mu transcripts are detected at all stages of development tested.

(Mullins et al., 1999)

AP-2mu transcripts are first detected in stage 9 embryos in the midgut and in the CNS. By stage 13, staining in both the midgut and CNS is strong and persists into later embryonic stages.

(Zhang and Broadie, 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of AP-2 adaptor complex

inferred from mutant phenotype

(Windler and Bilder, 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\AP-2μ in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\AP-2μ

View exonic expression by tissue for Dmel\AP-2μ

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263351

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42642/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263351

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024832

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263351

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7057

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of AP-2μ

Transgenic constructs containing regulatory region of AP-2μ

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6191

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PU

AP-2μ^JF02875

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

AP-2μ^GD12117

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

AP-2μ^GD12117

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

AP-2μ^GD12117

viable, with Scer\GAL4^tin.CΔ4

AP-2μ^GD12117

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

AP-2μ^JF02875

abnormal neuroanatomy | pupal stage P5 | somatic clone

AP-2μ^NN20

abnormal size | pupal stage P5 | somatic clone

AP-2μ^NN20

melanotic mass phenotype, with Scer\GAL4^{SPARC-MI00329-GAL4}

AP-2μ^JF02875

some die during pupal stage, with Scer\GAL4^pnr-MD237

AP-2μ^GD12117

Phenotype manifest in

Allele

dendritic tree | pupal stage P5 | somatic clone

AP-2μ^NN20

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^elav-C155

AP-2μ^JF02875

epithelium, with Scer\GAL4^NP1624

AP-2μ^KK100400

eye disc | somatic clone

AP-2μ^NN20

fat body, with Scer\GAL4^{SPARC-MI00329-GAL4}

AP-2μ^JF02875

female germline cyst, with Scer\GAL4^NP1624

AP-2μ^KK100400

larval dorsal multidendritic neuron ddaC | pupal stage P5 | somatic clone

AP-2μ^NN20

melanotic mass, with Scer\GAL4^{SPARC-MI00329-GAL4}

AP-2μ^JF02875

NMJ bouton | larval stage, with Scer\GAL4^elav-C155

AP-2μ^JF02875

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\AP2M1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Ap2m1

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Ap2m1

13 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\ap2m1

11 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (12)

Drer\ap2m1a

13 of 14

Yes

Drer\ap2m1b

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ston1

1 of 14

Drer\ston2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\dpy-23

13 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP007131

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (12)

Atha\AT5G46630

13 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\APM4

9 of 13

Yes

Scer\APM1

2 of 13

Scer\APM2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\apm4

12 of 12

Yes

Spom\apm3

2 of 12

Spom\apm1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:AP-2μ. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

AP-1μ

4 of 13

3 of 13

stnB

3 of 13

AP-1σ

1 of 13

AP-2σ

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

AP2M1; adaptor related protein complex 2 subunit mu 1

13 of 14

601024

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 60, WITH SEIZURES; MRD60

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

AP-2μ - AP-1-2β

experimental knowledge based

(Guruharsha et al., 2011)

AP-2μ - AP-2α

experimental knowledge based

(Guruharsha et al., 2011)

AP-2μ - AP-2σ

experimental knowledge based

(Guruharsha et al., 2011)

AP-2μ - Afti

anti tag coimmunoprecipitation, western blot

(Kametaka et al., 2012)

AP-2μ - Hexim

experimental knowledge based

(Guruharsha et al., 2011)

AP-2μ - Nak

anti tag coimmunoprecipitation, Identification by mass spectrometry, experimental knowledge based, western blot

(Guruharsha et al., 2011, Yang et al., 2011)

AP-2μ - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

AP-2μ - Reps

experimental knowledge based

(Guruharsha et al., 2011)

AP-2μ - Rlip

two hybrid, experimental knowledge based

(Guruharsha et al., 2011, Mirey et al., 2003, Jullien-Flores et al., 2000)

AP-2μ - SH3PX1

anti tag coimmunoprecipitation, western blot

(Worby et al., 2001)

AP-2μ - Srp72

experimental knowledge based

(Guruharsha et al., 2011)

AP-2μ - cnk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

AP-2μ - ed

pull down, autoradiography

(Ho et al., 2010)

AP-2μ - pav

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263351

MIST (protein-protein) - An integrated Molecular Interaction Database

42642

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O62530

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-74

Cytogenetic map

94A15-94A16

Sequence location

3R:22,462,455..22,464,603 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A15-94A16

Limits computationally determined from genome sequence between P{PZ}l(3)rQ178^rQ178 and P{lacW}Dph5^L4910

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

94B-94B

(Lloyd et al., 2000, Zhang, 1998.5.6)

94B1-94B2

(Mullins, 1998.12.1)

94B1-94B5

(determined by in situ hybridisation)

(Zhang and Broadie, 1999)

Experimentally Determined Recombination Data

Location

3-74

(FlyBase, 2016)

3-77.2

(Comeron et al., 2012)

(Menut et al., 2007)

Left of (cM)

Right of (cM)

Notes

Maps to 3R.

(Menut et al., 2007)

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

92514

y¹ v¹; P{U6.2-AP-2μ.dgRNA}attP40

30102

w¹¹¹⁸; P{EP}AP-2μ^G4842/TM6C, Sb¹

32610

w¹¹¹⁸; P{EP}AP-2μ^G7085/TM6C, Sb¹

28040

y¹ v¹; P{TRiP.JF02875}attP2/TM3, Sb¹

64751

w^*; wg^Sp-1/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2; P{neoFRT}82B AP-2μ^NN20/TM6C, Sb¹ Tb¹

VDRC

v103390

P{KK100400}VIE-260B

v27820

w¹¹¹⁸; P{GD12117}v27820

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (126)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD05403

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263351

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: AP-50 anon- EST:Posey50

(Bayraktaroglu, 2000.11.2)

Source for merge of: AP-50 anon-WO0172774.104

(FlyBase, 1996-)

Source for merge of: AP-50 MENE(3R)-D

(Windler and Bilder, 2010)

Additional comments

Source for merge of AP-50 anon-WO0172774.104 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: AP-2μ AP-50

(Bonifacino et al., 2012.12.21)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

AP-2mu

(Yassin et al., 2022, Solis et al., 2017)

AP-2μ

(Lee et al., 2024, Heigwer et al., 2023, Hodgson et al., 2022, Peterson et al., 2022, van de Leemput et al., 2022, Evans et al., 2021, Wang et al., 2021, Zong et al., 2018, Zang et al., 2015, Bonifacino et al., 2012.12.21, Jha et al., 2012, Windler and Bilder, 2010)

AP-50

(Zhao et al., 2020, Balakrishnan et al., 2015, Omelyanchuk et al., 2015, Borner et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Benhra et al., 2011, Friedman et al., 2011, Yang et al., 2011, Asensio et al., 2010, Ho et al., 2010, Liebl and Featherstone, 2008, Geng and MacDonald, 2007, Stuart et al., 2007, Akashi et al., 2006, Saleh et al., 2006)

AP2μ2

(Kametaka et al., 2012)

AP50

(Peters and Berg, 2016, Fletcher et al., 2012, Kametaka et al., 2010, Mohrmann et al., 2008, Bauer-DuMont et al., 2004, Begun, 2001, Begun and Whitley, 2000, Zhang and Broadie, 1999, Zhang, 1998.5.6)

CG7057

(Trivedi et al., 2020, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Cammarato et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Saleh et al., 2006, Boehm, 2001, Verstreken and Bellen, 2000.9.4)

Dμ2

(Jullien-Flores et al., 2000)

MENE (3R)-D

(Menut et al., 2007)

MENE(3R)-D

(Windler and Bilder, 2010)

anon-EST:Posey50

anon-WO0172774.104

apm4

(Neumann et al., 2010, Neumann et al., 2010)

cg7057

(Boehm and Bonifacino, 2002)

μ2

(Kametaka et al., 2012, Mohrmann et al., 2008, Boehm and Bonifacino, 2001, Mullins et al., 1999)

μ2-ada

(Choudhury et al., 2016)

Name Synonyms

AP-50

(Cammarato et al., 2011)

Adaptor Protein complex 2, μ subunit

(Bonifacino et al., 2012.12.21)

adaptor protein complex 2

(Mohrmann et al., 2008)

clathrin AP-2 complex

(Roman-Fernandez and Bryant, 2016)

μ2 medium chain of adaptin AP2

(Mirey et al., 2003)

μ2-adaptin

(Choudhury et al., 2016)

Secondary FlyBase IDs

FBgn0024832
FBgn0025529
FBgn0046487
FBgn0260567

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 64 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42642

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O62530

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

O62530

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O62530

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263351

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42642/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263351

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263351

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7057

MARRVEL_MODEL - MARRVEL (model organism gene)

42642

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263351

DroID - A comprehensive database of gene and protein interactions.

FBgn0263351

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

AP-2mu_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024832

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263351

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7057

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0263351

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011923

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

MIST (protein-protein) - An integrated Molecular Interaction Database

42642

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O62530

References (111)

The following external sites may use different assemblies or annotations than FlyBase.

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