beta3, β3, AP-3β, apl6
Please see the JBrowse view of Dmel\rb for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Gene model reviewed during 5.45
Gene model reviewed during 5.52
5.4, 5.2 (northern blot)
1160 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rb using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\rb in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
The rb gene product is part of the AP-3 adaptor complexs, which is critical for pigment granule formation.
Lesions in rb reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules: rb is required for normal pigmentation of all four tissues.
Pteridines (neodrosopterin, drosopterin, isodrosopterin, aurodrosopterin, 6-acetyl-dihydrohomopterin, sepiapterin, dihydrobiopterin, biopterin, pterin and isoxanthopterin) have been quantified in single and double mutants.
It is likely that this gene is required for the normal transport of eye-pigment precursors.
Source for merge of: rb beta3
FlyBase curator comment: the insertion in the "e04526" Exelixis line was originally assigned to the rb gene in FBrf0179797, resulting in the "rbe04526" (FBal0158738) allele. However, FBrf0184340 shows that the insertion is actually within CHOp24.