FB2024_04 , released June 25, 2024
Gene: Dmel\aos
Open Close
General Information
Symbol
Dmel\aos
Species
D. melanogaster
Name
argos
Annotation Symbol
CG4531
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004569
Gene Model Status
Current
Stock Availability
33 publicly available
Gene Summary
Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi). (UniProt, Q00805)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

rlt, gil, roulette, sty, arg

Key Links
Genomic Location
Cytogenetic map
73A2-73A2
Sequence location
Recombination map
3-44
RefSeq locus
NT_037436 REGION:16470386..16483650
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables epidermal growth factor receptor binding
inferred from direct assay
(Jin et al., 2000)
inferred from mutant phenotype
(Schnepp et al., 1998)
enables protein binding
inferred from physical interaction with FLYBASE:spi; FB:FBgn0005672
(Klein et al., 2004)
enables receptor antagonist activity
inferred from direct assay
(Klein et al., 2004, Jin et al., 2000)
inferred from mutant phenotype
(Schnepp et al., 1998)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (16 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
involved_in anterior/posterior axis specification
inferred from mutant phenotype
(Zhao and Bownes, 1999)
involved_in dorsal/ventral axis specification
inferred from mutant phenotype
(Zhao and Bownes, 1999)
involved_in eye development
inferred from mutant phenotype
(Charroux et al., 2006)
involved_in eye-antennal disc morphogenesis
inferred from mutant phenotype
(Brown et al., 2006)
involved_in genital disc development
inferred from mutant phenotype
(Chen et al., 2005)
involved_in haltere development
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Pallavi et al., 2006)
inferred from genetic interaction with FLYBASE:Ubx; FB:FBgn0003944
(Pallavi et al., 2006)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006, Pallavi and Shashidhara, 2003)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Marenda et al., 2006)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Greenspan et al., 2022, Spencer and Cagan, 2003, Kramer et al., 1999, Zhao and Bownes, 1999, Howes et al., 1998, Schnepp et al., 1998, Spencer et al., 1998)
inferred from direct assay
(Klein et al., 2004, Bang and Kintner, 2000, Jin et al., 2000, Vinos and Freeman, 2000, Golembo et al., 1996)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Gaengel and Mlodzik, 2003)
inferred from genetic interaction with FLYBASE:spi; FB:FBgn0005672
(Schweitzer et al., 1995)
inferred from genetic interaction with FLYBASE:Cbl; FB:FBgn0020224
(Robertson et al., 2000)
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Schnepp et al., 1998)
involved_in negative regulation of neurogenesis
inferred from mutant phenotype
(Morante et al., 2013)
involved_in negative regulation of stem cell differentiation
inferred from genetic interaction with FLYBASE:goe; FB:FBgn0027528
(Matsuoka et al., 2014)
involved_in oenocyte delamination
inferred from mutant phenotype
(Brodu et al., 2004)
involved_in ommatidial rotation
inferred from mutant phenotype
(Gaengel and Mlodzik, 2003)
involved_in positive regulation of apoptotic process
inferred from mutant phenotype
(Parker, 2006)
involved_in wing disc morphogenesis
inferred from mutant phenotype
(Pallavi and Shashidhara, 2003)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Schweitzer et al., 1995)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Protein Function (UniProtKB)
Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi).
(UniProt, Q00805)
Summary (Interactive Fly)

ligand for Egf receptor - inhibitor of Egfr activation - controls formation of embryonic brain neuroblasts by regulating neuroectodermal progenitor cells

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\aos for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q00805)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
aos-RA
FBtr0075408
NM_079383
2822
444
Additional Transcript Data and Comments
Reported size (kB)

4.5 (northern blot)

(Kretzschmar et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
aos-PA
FBpp0075166
49.9
444
7.92
Q00805
NP_524107
AAF49458
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

444 (aa)

(Freeman et al., 1992)

444 (aa); 50 (kD predicted)

(Kretzschmar et al., 1992)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with spi.

(UniProt, Q00805)
Domain

The three two-fingered repeats tightly encircle spi, providing the basis for it's sequestration. The first repeat harbors a 120 AA insert specific to drosophilidae.

(UniProt, Q00805)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aos using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.27

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | pair rule expression pattern
(Freeman et al., 1992)
midline glial cell
(Freeman et al., 1992)
embryonic stage 4 -- 5
cephalic furrow | anterior to
(Shandala et al., 1999)
cephalic furrow | posterior to
(Shandala et al., 1999)
embryo | anterior | dorsal
(Shandala et al., 1999)
embryo | dorsal | posterior
(Shandala et al., 1999)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
ventral midline of embryo
(Wessells et al., 1999)
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 9 -- 16
epidermis | ventral
(Freeman et al., 1992)
embryonic stage 10
mesoderm
(Yarnitzky et al., 1998)
embryonic stage 11
midline glial cell
(Wheeler et al., 2006)
embryonic posterior midline glial cell
(Wheeler et al., 2006)
embryonic/larval oenocyte precursor
(Brodu et al., 2004)
embryonic stage 11 -- 12
antennal primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
longitudinal visceral muscle primordium
(Fisher et al., 2012)
maxillary sensory complex primordium
(Fisher et al., 2012)
larval ventral midline glial cell
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13
midline glial cell
(Wheeler et al., 2006)
embryonic posterior midline glial cell
(Wheeler et al., 2006)
embryonic stage 13 -- 16
embryonic antennal sense organ
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut sensory structure
(Fisher et al., 2012)
embryonic maxillary sensory complex
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
embryonic/larval visceral muscle cell
(Fisher et al., 2012)
longitudinal visceral muscle fiber
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
midline glial cell

Comment: AMG

(Kearney et al., 2004)
embryonic stage 17
midline glial cell
(Wheeler et al., 2006)
third instar larval stage
eye-antennal disc
(Freeman et al., 1992)
Additional Descriptive Data

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

Expression is observed in the anterior midline glial cells.

(Kearney et al., 2004)

At cellularization, aos transcript is expressed in a pair of dorsal bands just anterior and posterior to the presumptive cephalic furrow, as well as in a dorsal terminal domain at bothe the anterior and posterior termini of the embryo.

(Shandala et al., 1999)

aos is expressed in a complex anddynamic pattern in embryos. It is first observed in the cellularblastoderm in dorsal regions at the anterior and posterior ends and in thedorsal ectoderm anlage, in a pair-rule pattern. At stage 9, expressionoccurs in two rows of ectodermal cells bordering the mesectoderm. As themesectoderm invaginates, the rows meet and aos expression occurs in theentire ventral ectoderm. In germ band extended embryos, additionalexpression is seen in the head region and in segmentally repeated groupsof ectodermal cells. aos is expressed in dorsal and lateral epidermalcells located at the segment boundary and in all ventral epidermal cellsuntil stage 16. As the germ band retracts, aos is expressed in themidline glial cells. In third instar larvae, aos is expressed behind themorphogenetic furrow. See the associated enhancer trap pattern forEcollacZargos-W11.

(Freeman et al., 1992)

The expression pattern of aos isidentical to that of the enhancer trap line EcollacZargos-A254.

(Kretzschmar et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc morphogenetic furrow
(Moon et al., 2006)
eye disc posterior to the morphogenetic furrow
(Moon et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Schweitzer et al., 1995)
Expression Deduced from Reporters
Reporter: P{lwB}aosW11
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | pair rule expression pattern
(Freeman et al., 1992)
midline glial cell
(Klaes et al., 1994, Freeman et al., 1992)
embryonic stage 9 -- 16
epidermis | ventral
(Freeman et al., 1992)
third instar larval stage
cone cell
(Freeman et al., 1992)
eye-antennal disc
(Freeman et al., 1992)
primary pigment cell
(Freeman et al., 1992)
photoreceptor cell R1 -- photoreceptor cell R8
(Freeman et al., 1992)
pupal stage P6
bract primordium of leg

Comment: 28h APF

(Peng et al., 2012)
adult stage
lamina | restricted
(Freeman et al., 1992)
cone cell
(Freeman et al., 1992)
Reporter: P{PZ}aos05845
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
imaginal disc
(Meister and Braun, 1995.10)
pupal stage P6 -- P7
bract of tibia
(Mou et al., 2012)
Reporter: P{PZ}aos05959
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc | restricted
(Treisman and Rubin, 1996)
dorsal-ventral compartment boundary of the wing disc | vicinity of
(Pallavi et al., 2006)
presumptive wing vein L3
(Pallavi et al., 2006)
presumptive wing vein L4
(Pallavi et al., 2006)
presumptive wing vein L5
(Pallavi et al., 2006)
haltere disc | restricted

Comment: presumptive hinge; NOT haltere pouch

(Pallavi et al., 2006)
dorsal mesothoracic pleura primordium

Comment: mesonotum

(Pallavi et al., 2006)
wing hinge primordium
(Pallavi et al., 2006)
wing pouch | restricted
(Pallavi et al., 2006)
Reporter: P{PZ}aosrJ472
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage P6
wing vein L3
(Conley et al., 2000)
wing vein L4
(Conley et al., 2000)
wing vein L5
(Conley et al., 2000)
crossvein

Comment: 28-32 hr APF

(Conley et al., 2000)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\aos in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 47 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 50 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of aos
Transgenic constructs containing regulatory region of aos
Aberrations (Deficiencies and Duplications) ( 18 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4Bx-MS1096
lethal, with Scer\GAL4Tub.PU
lethal (with Df(3L)st-f13)
lethal (with Df(3L)st-k7)
lethal | heat sensitive
lethal | recessive
lethal - all die during embryonic stage
lethal - all die during embryonic stage (with Df(3L)st-g18)
lethal - all die during embryonic stage | recessive
partially lethal, with Scer\GAL4Tub.PU
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4Tub.PU
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
abnormal cell polarity
abnormal cell polarity (with aos5F4)
abnormal cell polarity (with aosA254Δ15)
abnormal cell polarity (with aosrlt)
abnormal cell polarity (with aosΔ7)
abnormal cell polarity | somatic clone
abnormal immune response | adult stage, with Scer\GAL4NP5130
abnormal neuroanatomy | third instar larval stage
abnormal size, with Scer\GAL4Bx-MS1096
abnormal song
abnormal visual behavior
decreased cell number | embryonic stage, with Scer\GAL4en-e16E
decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4NP5130
decreased occurrence of cell division | larval stage
increased cell death | embryonic stage, with Scer\GAL4en-e16E
increased cell size | embryonic stage, with Scer\GAL4en-e16E
short lived, with Scer\GAL4Mef2.PR
some die during embryonic stage
some die during embryonic stage (with Df(3L)st-g18)
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL469B
visible, with Scer\GAL471B
visible, with Scer\GAL4bs-1348
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4Dll-md23
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4hs.2sev
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-C253
visible, with Scer\GAL4unspecified
visible (with aos257)
visible (with aosp1)
visible (with aosW11)
visible (with aosΔ7)
visible (with Df(3L)Exel6129)
visible | adult stage, with Scer\GAL4GMR.PU
visible | dominant
visible | recessive
wild-type
Phenotype manifest in
Allele
1st posterior cell
2nd posterior cell
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 7 lateral pentascolopidial chordotonal organ lch5
abdominal lateral pentascolopidial chordotonal organ lch5 | increased number
abdominal sternite bristle | ectopic
adult apodeme & leg, with Scer\GAL4Dll-md23
adult optic lobe
anterior crossvein, with Scer\GAL469B
anterior crossvein, with Scer\GAL4en-e16E
anterior dorsocentral bristle, with Scer\GAL4sca-C253
anterior postalar bristle, with Scer\GAL4sca-C253
anterior scutellar bristle, with Scer\GAL4sca-C253
anterior supraalar bristle, with Scer\GAL4sca-C253
Bolwig nerve
Bolwig organ
bract, with Scer\GAL4sca-537.4
bract | increased number
chaeta, with Scer\GAL4pnr-MD237
chaeta | increased number, with Scer\GAL4pnr-MD237
chordotonal organ | lateral
cone cell
cone cell, with Scer\GAL4hs.2sev
cone cell | heat sensitive
crossvein
crossvein, with Scer\GAL4dpp.blk1
dorsal acute muscle cell | ectopic
dorsal acute muscle cell | ectopic | precursor
dorsal appendage
dorsal appendage (with aosW11)
dorsal appendage (with aosΔ7)
dorsal appendage | maternal effect (with aos257)
dorsal appendage | maternal effect (with aosp1)
dorsal appendage | maternal effect (with aosW11)
dorsal appendage | maternal effect (with aosΔ7)
dorsal appendage | somatic clone
dorsal oblique muscle cell | ectopic
dorsal oblique muscle cell | ectopic | precursor
egg
egg chorion
egg operculum
egg operculum | ectopic
embryonic/larval brain | embryonic stage
embryonic/larval brain | third instar larval stage
embryonic/larval oenocyte | increased number
embryonic/larval oenocyte | increased number, with Scer\GAL4en-e16E
embryonic/larval oenocyte precursor | increased number
embryonic/larval oenocyte precursor | increased number, with Scer\GAL4en-e16E
embryonic/larval optic lobe
embryonic/larval recurrent nerve
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
embryonic head
embryonic ventral epidermis
eye
eye, with Scer\GAL469B
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye, with Scer\GAL4unspecified
eye (with aos257)
eye (with aosp1)
eye (with aosW11)
eye (with aosΔ7)
eye (with Df(3L)Exel6129)
eye (with Df(3L)st-f13)
eye (with Df(3L)st-k7)
eye | posterior
eye | posterior (with aos05845)
eye | posterior (with aosΔ7)
eye | somatic clone
eye photoreceptor cell
eye photoreceptor cell, with Scer\GAL4GMR.PF
eye photoreceptor cell & axon
eye photoreceptor cell | ectopic
eye photoreceptor cell | ectopic (with aos5F4)
eye photoreceptor cell | ectopic (with aosA254Δ15)
eye photoreceptor cell | ectopic (with aosrlt)
eye photoreceptor cell | ectopic (with aosΔ7)
eye photoreceptor cell | heat sensitive
eye photoreceptor cell | somatic clone | increased number
frontal ganglion
genital disc primordium
glial cell & antennal disc, with Scer\GAL4hs.PB
hypocerebral ganglion
hypostomal sclerite
interommatidial bristle
interommatidial bristle & eye | precursor
lamina
lamina & glial cell
larval neuroblast | ectopic | third instar larval stage
larval ventral nerve cord
larval ventral nerve cord | heat sensitive
lens
lobula
macrochaeta & mesothoracic tergum, with Scer\GAL4sca-C253
Malpighian tubule
maxillary palp
medulla
mesothoracic dorsal triscolopidial chordotonal organ dch3
mesothoracic tarsal segment 1 & bract, with Scer\GAL4Dll-md23
mesothoracic tarsal segment 1 & bract, with Scer\GAL4sca-537.4
mesothoracic tarsal segment 1 & bract | dorsal, with Scer\GAL4Dll-md23
mesothoracic tergum, with Scer\GAL4pnr-MD237
mesothoracic tergum, with Scer\GAL4Ubx-lac1-Gal4
mesothoracic tibial apical bristle, with Scer\GAL4Dll-md23
mesothoracic tibial apical bristle, with Scer\GAL4sca-537.4
mesothoracic tibial bract, with Scer\GAL4Dll-md23
mesothoracic tibial bract, with Scer\GAL4sca-537.4
microchaeta & mesothoracic tergum, with Scer\GAL4sca-C253
micropyle | ectopic
midgut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
midline glial cell
midline glial cell | heat sensitive
mystery cell
mystery cell (with aos5F4)
mystery cell (with aosΔ7)
oenocyte primordium
oenocyte primordium, with Scer\GAL4en-e16E
ommatidial precursor cluster (with aos5F4)
ommatidial precursor cluster (with aosΔ7)
ommatidium
ommatidium, with Scer\GAL469B
ommatidium, with Scer\GAL4hs.2sev
ommatidium (with aos5F4)
ommatidium (with aosA254Δ15)
ommatidium (with aosrlt)
ommatidium (with aosΔ7)
ommatidium | heat sensitive
ommatidium | somatic clone
optic nerve
pericardial cell | ectopic
pericardial cell | ectopic | precursor
photoreceptor
photoreceptor cell R1
photoreceptor cell R1 | somatic clone
photoreceptor cell R2
photoreceptor cell R2 | somatic clone
photoreceptor cell R3
photoreceptor cell R3 | ectopic (with aos5F4)
photoreceptor cell R3 | ectopic (with aosΔ7)
photoreceptor cell R3 | somatic clone
photoreceptor cell R4
photoreceptor cell R4 | ectopic (with aos5F4)
photoreceptor cell R4 | ectopic (with aosΔ7)
photoreceptor cell R4 | somatic clone
photoreceptor cell R5
photoreceptor cell R5 | somatic clone
photoreceptor cell R6
photoreceptor cell R6 | somatic clone
photoreceptor cell R8
photoreceptor cell R8 | somatic clone
photoreceptor neuron
photoreceptor neuron | ectopic
pigment cell
pigment cell | heat sensitive
posterior crossvein, with Scer\GAL4en-e16E
posterior postalar bristle, with Scer\GAL4sca-C253
posterior scutellar bristle, with Scer\GAL4sca-C253
posterior supraalar bristle, with Scer\GAL4sca-C253
presumptive embryonic/larval central nervous system
pretarsus, with Scer\GAL4Dll-md23
prothoracic tibial apical bristle, with Scer\GAL4Dll-md23
prothoracic tibial apical bristle, with Scer\GAL4sca-537.4
retina
retina & axon
rhabdomere
secondary pigment cell, with Scer\GAL4hs.2sev
secondary pigment cell | heat sensitive
symmetrical commissure
symmetrical commissure | heat sensitive
taste bristle & leg | ectopic, with Scer\GAL4Dll-md23
taste bristle & leg | ectopic, with Scer\GAL4sca-537.4
tertiary pigment cell, with Scer\GAL4hs.2sev
tertiary pigment cell | heat sensitive
unguis, with Scer\GAL4Dll-md23
ventral denticle belt
ventral denticle belt (with aosΔ5)
ventral denticle belt (with aosΔ7)
visual primordium
wing
wing, with Scer\GAL469B
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4Ubx-lac1-Gal4
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc, with Scer\GAL4ap-md544
wing disc, with Scer\GAL4tsh-md621
wing disc, with Scer\GAL4Ubx-lac1-Gal4
wing vein
wing vein, with Scer\GAL469B
wing vein, with Scer\GAL471B
wing vein, with Scer\GAL4bs-1348
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4en-e16E
wing vein | ectopic, with Scer\GAL4604
wing vein L2
wing vein L3, with Scer\GAL4dpp.blk1
wing vein L4
wing vein L4, with Scer\GAL469B
wing vein L4, with Scer\GAL4Bx-MS1096
wing vein L4, with Scer\GAL4en-e16E
wing vein L5
wing vein L5, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP007021
1 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:aos. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    aos - spi
    surface plasmon resonance
    (Miura et al., 2006)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    aos
    suppressible
    bul
    (Taguchi et al., 2000, Wemmer and Klämbt, 1995)
    aos
    enhanceable
    bul
    (Wemmer and Klämbt, 1995)
    aos
    enhanceable
    ca
    (Harris et al., 2011)
    aos
    enhanceable
    cd
    (Harris et al., 2011)
    aos
    suppressible
    cln
    (Taguchi et al., 2000, Wemmer and Klämbt, 1995)
    aos
    enhanceable
    Dcr-2
    (Harris et al., 2011, Dietzl et al., 2007)
    aos
    enhanceable
    Delta
    (Carmena et al., 2002)
    aos
    suppressible
    Diap1
    (Sawamoto et al., 1998)
    aos
    suppressible
    Diap2
    (Sawamoto et al., 1998)
    aos
    suppressible
    Dsor1
    (Sawamoto et al., 1996)
    aos
    enhanceable
    E-3c1
    (Coelho et al., 2005)
    aos
    enhanceable
    E-3c4
    (Coelho et al., 2005)
    aos
    enhanceable
    E-3c7
    (Coelho et al., 2005)
    aos
    enhanceable
    ebi
    (Marygold et al., 2011)
    aos
    suppressible
    ed
    (Bai et al., 2001)
    aos
    suppressible
    Edem2
    (Zettl et al., 2011)
    aos
    suppressible
    Egfr
    (Gaengel and Mlodzik, 2003, Carmena et al., 2002, Schweitzer et al., 1995)
    aos
    enhanceable
    EM3-1
    (Taguchi et al., 2000)
    aos
    suppressible
    Fas2
    (Mao and Freeman, 2009)
    aos
    enhanceable
    Gug
    (Charroux et al., 2006)
    aos
    suppressible
    Gug
    (Charroux et al., 2006)
    aos
    suppressible
    Hsp60D
    (Arya and Lakhotia, 2008)
    aos
    enhanceable
    lep
    (Coelho et al., 2005)
    aos
    suppressible
    lz
    (Wildonger et al., 2005)
    aos
    enhanceable
    msk
    (Marenda et al., 2006)
    aos
    enhanceable
    ncm
    (Coelho et al., 2005)
    aos
    suppressible
    nmo
    (Gaengel and Mlodzik, 2003)
    aos
    enhanceable
    p
    (Harris et al., 2011)
    aos
    suppressible
    Pi3K68D
    (MacDougall et al., 2004)
    aos
    enhanceable
    Pi3K68D
    (MacDougall et al., 2004)
    aos
    enhanceable
    pix
    (Coelho et al., 2005)
    aos
    suppressible
    pnt
    (Gaengel and Mlodzik, 2003)
    aos
    enhanceable
    Prp8
    (Coelho et al., 2005)
    aos
    suppressible
    Raf
    (Sawamoto et al., 1996)
    aos
    suppressible
    Ras85D
    (Gaengel and Mlodzik, 2003, Sawamoto et al., 1998, Sawamoto et al., 1996)
    aos
    enhanceable
    rb
    (Harris et al., 2011)
    aos|sty
    enhanceable
    rho-5
    (Zettl et al., 2011)
    aos
    suppressible
    rho-5
    (Zettl et al., 2011)
    aos
    enhanceable
    rho
    (Sawamoto et al., 1994)
    aos
    suppressible
    rl
    (Sawamoto et al., 1996)
    aos
    enhanceable
    rno
    (Voas and Rebay, 2003)
    aos
    enhanceable
    RpL5
    (Coelho et al., 2005)
    aos
    enhanceable
    RpL38
    (Coelho et al., 2005)
    aos
    suppressible
    S
    (Sawamoto et al., 1996, Sawamoto et al., 1996)
    aos
    enhanceable
    S
    (Taguchi et al., 2000, Sawamoto et al., 1996)
    aos
    enhanceable
    salm
    (Elstob et al., 2001)
    aos
    suppressible
    sip3
    (Zettl et al., 2011)
    aos
    suppressible
    SM2-1
    (Taguchi et al., 2000)
    aos
    suppressible
    SM3-2
    (Taguchi et al., 2000)
    aos
    suppressible
    SM3-3
    (Taguchi et al., 2000)
    aos
    suppressible
    SM3-6
    (Taguchi et al., 2000)
    aos
    suppressible
    SM3-8
    (Taguchi et al., 2000)
    aos
    suppressible
    soba
    (Wemmer and Klämbt, 1995)
    aos
    suppressible
    Socs44A
    (Rawlings et al., 2004)
    aos
    suppressible
    sty
    (Taguchi et al., 2000, Casci et al., 1999, Kramer et al., 1999)
    aos
    suppressible
    Vav
    (Martín-Bermudo et al., 2015)
    aos
    suppressible
    vn
    (Wessells et al., 1999)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    arm
    enhanceable
    aos
    (Greaves et al., 1999)
    arm
    suppressible
    aos
    (Freeman and Bienz, 2001)
    btl::Egfr
    enhanceable
    aos
    (Pallavi et al., 2006)
    bul
    enhanceable
    aos
    (Wemmer and Klämbt, 1995)
    bul
    suppressible
    aos
    (Wemmer and Klämbt, 1995)
    Cbl
    enhanceable
    aos
    (Robertson et al., 2000)
    Chmp1
    enhanceable
    aos
    (Valentine et al., 2014)
    csw
    enhanceable
    aos
    (Oishi et al., 2009, Oishi et al., 2006)
    Delta
    enhanceable
    aos
    (Carmena et al., 2002)
    Delta
    suppressible
    aos
    (Culi et al., 2001)
    Dg
    enhanceable
    aos
    (Kucherenko et al., 2008)
    Dys
    suppressible
    aos
    (Kucherenko et al., 2008)
    ed
    enhanceable
    aos
    (Rawlins et al., 2003, Spencer and Cagan, 2003)
    Egfr
    enhanceable
    aos
    (Pallavi et al., 2006, Lesokhin et al., 1999)
    Egfr
    suppressible
    aos
    (Carmena et al., 2002, Lesokhin et al., 1999)
    Fas2
    enhanceable
    aos
    (Mao and Freeman, 2009)
    fz
    enhanceable
    aos
    (Strutt and Strutt, 2003)
    goe
    enhanceable
    aos
    (Matsuoka et al., 2014)
    H
    suppressible
    aos
    (Protzer et al., 2008)
    hid
    suppressible
    aos
    (Bergmann et al., 1998)
    hid
    suppressible
    aos|Ack
    (Schoenherr et al., 2012)
    miple1
    enhanceable
    aos
    (Muñoz-Soriano et al., 2013)
    Mtl
    enhanceable
    aos
    (Muñoz-Descalzo et al., 2007)
    Pcyt1
    enhanceable
    N|aos
    (Weber et al., 2003)
    Rac1
    suppressible
    aos
    (Fanto et al., 2000)
    Ras64B
    suppressible
    aos
    (Strutt and Strutt, 2003)
    Ras85D
    enhanceable
    aos
    (Voas and Rebay, 2003)
    rg
    suppressible
    aos
    (Shamloula et al., 2002)
    rg
    enhanceable
    aos
    (Shamloula et al., 2002)
    rho-5|sty
    enhanceable
    aos
    (Zettl et al., 2011)
    rho
    enhanceable
    aos
    (Sawamoto et al., 1994)
    rho
    suppressible
    aos
    (Brodu et al., 2004)
    rl
    suppressible
    aos
    (Sawamoto et al., 1996)
    salm
    enhanceable
    aos
    (Elstob et al., 2001)
    sl
    enhanceable
    aos
    (Murillo-Maldonado et al., 2011, Schlesinger et al., 2004)
    Snr1
    enhanceable
    aos
    (Curtis et al., 2011)
    Socs44A
    enhanceable
    aos
    (Rawlings et al., 2004)
    sty
    enhanceable
    aos
    (Zettl et al., 2011)
    tum
    enhanceable
    aos
    (Sotillos and Campuzano, 2000)
    Ubx
    suppressible
    aos
    (Pallavi et al., 2006)
    vn
    suppressible
    aos
    (Donaldson et al., 2004, Wessells et al., 1999)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with spi.
    (UniProt, Q00805 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Negative Regulators of EGFR Signaling Pathway -
    Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-44
    Cytogenetic map
    73A2-73A2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    73A2-73A2
    Limits computationally determined from genome sequence between P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532 and P{PZ}Baldspot02281
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    73A1-73A2
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    73A1-73A2
    73A1--4
    (BDGP Project Members, 1994-1999)
    73A-73A
    (determined by in situ hybridisation)
    (Kretzschmar et al., 1992)
    73A3-73A4
    (determined by in situ hybridisation)
    (Freeman et al., 1992)
    Experimentally Determined Recombination Data
    Location

    3-44

    (FlyBase, 2016)

    3-39.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    (Wemmer and Klämbt, 1995)
    Notes
    Stocks and Reagents
    Stocks (33)
    Genomic Clones (27)
    cDNA Clones (49)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          argos is not required for patterning of the dorsal anterior follicular epithelium.

          (Lachance et al., 2009)

          ChEST reveals this is a target of Mef2.

          (Junion et al., 2005)

          argos mediate the number of bracts per mechanosensory bristle in the leg by lateral inhibition.

          (del Alamo et al., 2002)

          argos exerts its inhibitory function through dual mechanisms: by blocking both the receptor dimerisation and the binding of activating ligand to the receptor.

          (Jin et al., 2000)

          argos has a role in dorsal-ventral and anterior-posterior patterning in the egg.

          (Zhao and Bownes, 1999)

          The extended B loop of the atypical argos EGF domain is necessary for its function.

          (Howes et al., 1998)

          EGF domain swapping experiments of vn, spi and argos demonstrate that the EGF domain is the key determinant that gives Egfr inhibitors and activators their distinct properties.

          (Schnepp et al., 1998)

          argos modifies the initial Egfr activation profile of the follicle cells, resulting in twin peaks of activity displaced from the midline.

          (Wasserman and Freeman, 1998)

          Shows no genetic interaction with sdk.

          (Nguyen et al., 1997)

          In vivo culture of mutant discs from genotypes that are normally embryonic lethal demonstrates argos has no role in wing disc growth.

          (Simcox, 1997)

          argos is a negative regulator of midline glia cell survival in embryos.

          (Stemerdink and Jacobs, 1997)

          argos is a secondary target gene of Egfr, activated by pnt in response to Egfr signalling. The proper induction of argos requires the concomitant inactivation of aop, mediated by Egfr signalling.

          (Gabay et al., 1996)

          argos is necessary for fate determination in the ventral ectoderm. argos can be induced by Egfr activation in vivo and in Schneider cells.

          (Golembo et al., 1996)

          argos acts negatively to restrict the number of chordotonal (Ch) organs but not external sensory (Es) organs.

          (Okabe et al., 1996)

          A null mutation causes an increase in chordotonal (Ch) organs in thoracic and abdominal segments. Overexpression causes a reduction in number of Ch organs. The phenotype of a argos null mutant is not observed in a rho mutant background, indicating that rho acts epistatically to argos to regulate the correct number of Ch organs in the embryonic PNS.

          (Okabe et al., 1996)

          The argos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade.

          (Sawamoto et al., 1996)

          argos is required for projection of photoreceptor axons during optic lobe development.

          (Sawamoto et al., 1996)

          Clonal analysis demonstrates argos is not required in the photoreceptor axons for correct axonal pathfinding.

          (Brunner et al., 1995)

          argos is required for development of embryonic PNS and for larval retinal axon guidance. The argos gene is likely to play a role in a sensory organ precursor formation process such as cell division or cell death in a cell autonomous fashion.

          (Okano et al., 1995)

          The argos product plays an essential role in optic lobe development.

          (Sawamoto et al., 1995)

          argos represses the Egfr pathway in vivo and in vitro the argos protein can inhibit the activation of Egfr by spi. Thus the determination of cells by the Egfr pathway is regulated by a balance between extracellular activating and inhibiting signals.

          (Schweitzer et al., 1995)

          bul, soba and cln are candidates for argos receptor genes or may encode proteins that are involved in the elaboration or perception of the argos signal.

          (Wemmer and Klämbt, 1995)

          argos mutants act on the development of lamina cells preventing the correct differentiation of the target region of photoreceptor axons and therefore leading to an axon guidance phenotype.

          (Brunner et al., 1994)

          The argos locus was identified on the basis of the rough eye phenotype of its mutants.

          (Choi and Benzer, 1994)

          Overexpression of argos causes the loss of cells in the developing eye.

          (Freeman, 1994)

          argos functions to regulate cell fate decisions as a negative signal in the developing eye and wing discs.

          (Sawamoto et al., 1994)

          argos gene product may be a new type of secreted signalling molecule involved in the process of axon pathfinding and cell determination in the visual system.

          (Brunner et al., 1993)

          argos may act as an inhibitory signal for cellular differentiation in the developing eye and wing.

          (Sawamoto et al., 1993)

          Clonal analysis indicates that argos acts nonautonomously.

          (Freeman et al., 1992)

          Phenotypic analysis of argos mutations in the developing eye suggest that argos is a diffusable negative regulator of inductive signals that specifies cell fate and can transmit a signal over a distance.

          (Freeman et al., 1992)

          argos has important functions in cell determination in the eye, in photoreceptor axon pathfinding and in optic lobe development.

          (Kretzschmar et al., 1992)

          argos gene product is an inhibitory signal that regulates neuronal differentiation in the eye imaginal discs. argos is also required for normal development of the cephalic regions and the wings and for axonal guidance in the optic lobe.

          (Okano et al., 1992)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: argos rlt

          (Strutt and Strutt, 2003, Weber et al., 2003)
          Additional comments

          "rlt" is a regulatory allele of "argos".

          (Strutt and Strutt, 2003)
          Nomenclature History
          Source for database identify of

          Source for identity of: argos rlt

          (Strutt and Strutt, 2003)

          Source for identity of: aos argos

          (FlyBase, 2009-)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (19)
          Reported As
          Symbol Synonym
          Aos
          (Malartre, 2016, Mbodj et al., 2013, Donaldson et al., 2004, Ghiglione et al., 2002, Iwanami et al., 2002, Jin et al., 2000, Vinos and Freeman, 2000, Martin-Blanco et al., 1999, Michelson, 1999.8.9, Schnepp et al., 1998)
          Argos
          (Bolus et al., 2020, Liu and Pfleger, 2013, Foronda et al., 2012, Stec and Zeidler, 2011, Usha and Shashidhara, 2010, Ninov et al., 2009, Bruinsma et al., 2007, Reeves et al., 2006)
          CG4531
          (Hosono et al., 2015, Walls et al., 2013, Mosallanejad et al., 2010, Krejcí et al., 2009, Perkins et al., 2009, Grieder et al., 2007, Molnar et al., 2006, Raisin et al., 2003)
          DmAos
          (Alvarado et al., 2006)
          aos
          (Kim et al., 2023, Muita and Baxter, 2023, Xu et al., 2023, Perlegos et al., 2022, Marmion et al., 2021, Das and Bhadra, 2020, Statzer and Ewald, 2020, Chai et al., 2019, Koca et al., 2019, Wittes and Schüpbach, 2019, Boisclair Lachance et al., 2018, Hope et al., 2018, Jia et al., 2018, Kittelmann et al., 2018, Ogura et al., 2018, Webber et al., 2018, Johnson et al., 2017, Osterfield et al., 2017, Suisse et al., 2017, Transgenic RNAi Project members, 2017-, Blick et al., 2016, Dollar et al., 2016, Jussen et al., 2016, Legent et al., 2015, Matsuda et al., 2015, Fauré et al., 2014, Valentine et al., 2014, Liu and Pfleger, 2013, Morante et al., 2013, Muñoz-Soriano et al., 2013, Sen et al., 2013, Steinhauer et al., 2013, Webber et al., 2013, Butchar et al., 2012, Foronda et al., 2012, Legent et al., 2012, Mou et al., 2012, Peng et al., 2012, Dworkin et al., 2011, Helman et al., 2011, Mirkovic et al., 2011, Murillo-Maldonado et al., 2011, Bernard et al., 2010, Rendina et al., 2010, Roignant and Treisman, 2010, Salzer et al., 2010, Debat et al., 2009, Fetting et al., 2009, Huh et al., 2009, Krejcí et al., 2009, Lachance et al., 2009, Nicholson et al., 2009, Oishi et al., 2009, Pizette et al., 2009, Terriente-Félix and de Celis, 2009, Yan et al., 2009, del Alamo and Mlodzik, 2008, McNeill et al., 2008, Miura et al., 2008, Doroquez et al., 2007, Luo et al., 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Tyler et al., 2007, Carmena et al., 2006, Dworkin and Gibson, 2006, Lam et al., 2006, Miura et al., 2006, Oishi et al., 2006, Parker, 2006, Dutta et al., 2005, Galindo et al., 2005, Iwanami et al., 2005, Stathopoulos and Levine, 2005, Wildonger et al., 2005, MacDougall et al., 2004, Wildonger et al., 2004, Alvarez et al., 2003, Chang et al., 2003, Escudero et al., 2003, Nakamura and Matsuno, 2003, Rawlins et al., 2003, Voas and Rebay, 2003, Weber et al., 2003, Carmena et al., 2002, del Alamo et al., 2002, Galindo et al., 2002, Bai et al., 2001, Chang et al., 2001, Kumar and Moses, 2001, Yang and Baker, 2001, Brennan and Moses, 2000, Carmena et al., 2000, Firth et al., 2000, Carmena et al., 1999, Chen and Chien, 1999, Daniel et al., 1999, Greaves et al., 1999, Lesokhin et al., 1999, Matakatsu et al., 1999, Shandala et al., 1999, Wessells et al., 1999, Biehs et al., 1998, Dumstrei et al., 1998, Kerber et al., 1998, Szuts et al., 1998, Buff et al., 1997, Perrimon and Perkins, 1997, Queenan et al., 1997, Simcox, 1997, Szuts et al., 1997, Yagi and Hayashi, 1997, Huang and Fischer-Vize, 1996, Wemmer and Klämbt, 1995, Freeman et al., 1991)
          arg
          (Gafuik and Steller, 2011, Bergmann et al., 1998, Sawamoto et al., 1994)
          argos
          (Klebanow et al., 2016, Sandler and Stathopoulos, 2016, Sarov et al., 2016, Shimaji et al., 2016, Liu and Pfleger, 2013, Webber et al., 2013, Foronda et al., 2012, Curtis et al., 2011, Baig et al., 2010, Chanut-Delalande et al., 2010, Djiane and Mlodzik, 2010, Ho et al., 2010, Zhang et al., 2010, Ayroles et al., 2009, Mallik and Lakhotia, 2009, Mao and Freeman, 2009, Yan et al., 2009, Zartman et al., 2009, Andrew and Baker, 2008, Arya and Lakhotia, 2008, Christensen et al., 2008.7.11, Christensen et al., 2008.7.11, Christensen et al., 2008.7.11, Duong et al., 2008, Kucherenko et al., 2008, Protzer et al., 2008, Tran et al., 2008, Xi et al., 2008, Yakoby et al., 2008, de Navascués and Modolell, 2007, Dietzl et al., 2007, Grieder et al., 2007, Magalhaes et al., 2007, Roignant et al., 2007, Shirai et al., 2007, Zeitlinger et al., 2007, Zeitlinger et al., 2007, Brown et al., 2006, Charroux et al., 2006, Molnar et al., 2006, Moon et al., 2006, Pai et al., 2006, Pallavi et al., 2006, Roignant et al., 2006, Wheeler et al., 2006, Sotillos and De Celis, 2005, Brodu et al., 2004, Rawlings et al., 2004, Schlesinger et al., 2004, Pribyl et al., 2003, Robertson et al., 2000)
          gil
          (Spradling et al., 1999, Okabe et al., 1996, Brunner et al., 1995, Okano et al., 1995, Schweitzer et al., 1995, Brunner et al., 1993, Kretzschmar et al., 1992, Schneuwly, 1992.3.27)
          l(3)05845
          l(3)05959
          l(3)j5E11
          l(3)rJ472
          l(3)rJ812
          l(3)rQ526
          rlt
          (Strutt and Strutt, 2003, Weber et al., 2003, Mlodzik, 2002, Fanto, 2000, Fanto et al., 2000, Mlodzik, 2000, Boutros and Mlodzik, 1999, Mlodzik, 1999, Reifegerste and Moses, 1999, Shulman et al., 1998, Bonini and Choi, 1995, Choi and Benzer, 1994)
          sty
          (Okano, 1993.4.1, Sawamoto, 1993, Okano et al., 1992)
          Name Synonyms
          Argos
          (Malartre, 2016, Makki et al., 2014, Murillo-Maldonado et al., 2011, Majumdar et al., 2010, Buchon et al., 2009, Hurlbut et al., 2009, Moran and Kyriacou, 2009, Aritakula and Ramasamy, 2008, Klein et al., 2008, Moon et al., 2007, Reeves and Shvartsman, 2007, Alvarado et al., 2006, Dworkin and Gibson., 2006, Iwanami et al., 2005, Fanto and McNeill, 2004, Voas and Rebay, 2004, Firth and Baker, 2003, Ruden and Xiao, 2002, Jin et al., 2000, Sawamoto et al., 1998, Freeman et al., 1997, Jacobs et al., 1997, Sawamoto et al., 1997, Sanson et al., 1996)
          aos
          (Ho et al., 2010)
          argos
          (Moreno et al., 2019, Das et al., 2018, Duan et al., 2018, O'Hanlon et al., 2018, Osterfield et al., 2017, Revaitis et al., 2017, Jussen et al., 2016, Xu et al., 2016, Forés et al., 2015, Hall and Verheyen, 2015, Martín-Bermudo et al., 2015, Matsuda et al., 2015, Housden et al., 2014, Matsuoka et al., 2014, Hahn et al., 2013, Molnar and de Celis, 2013, Sopko and Perrimon, 2013, Steinhauer et al., 2013, Webber et al., 2013, Chakrabarti et al., 2012, Schoenherr et al., 2012, Vivekanand and Rebay, 2012, Wheeler et al., 2012, Ajuria et al., 2011, Harris et al., 2011, Helman et al., 2011, Hogan et al., 2011, Kuraishi et al., 2011, Zettl et al., 2011, Aerts et al., 2010, Baig et al., 2010, Bernard et al., 2010, Buchon et al., 2010, Majumdar et al., 2010, Rendina et al., 2010, Salzer et al., 2010, Terriente-Félix et al., 2010, Usha and Shashidhara, 2010, Krejcí et al., 2009, Maybeck and Röper, 2009, Nicholson et al., 2009, Pizette et al., 2009, Terriente-Félix and de Celis, 2009, Yan et al., 2009, Fiehler and Wolff, 2008, Kucherenko et al., 2008, McNeill et al., 2008, Roukens et al., 2008, Astigarraga et al., 2007, Beltran et al., 2007, Doroquez et al., 2007, Grieder et al., 2007, Luo et al., 2007, Dworkin and Gibson, 2006, Oishi et al., 2006, Pai et al., 2006, Parker, 2006, Galindo et al., 2005, Melen et al., 2005, Sotillos and De Celis, 2005, MacDougall et al., 2004, Pribyl et al., 2003, Robertson et al., 2000, Vinos and Freeman, 2000, Wessells et al., 1999)
          giant lens
          roulette
          (Strutt, 2003, Strutt and Strutt, 2003, Weber et al., 2003, Wolff, 2003, Choi and Benzer, 1994)
          strawberry
          (Yamamoto, 1993)
          Secondary FlyBase IDs
          • FBgn0010878
          • FBgn0011388
          • FBgn0011502
          • FBgn0011505
          • FBgn0011527
          • FBgn0014382
          • FBgn0020286
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 53 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          References (505)