FlyBase Allele Report: Dmel\dlp[A187]

General Information

Symbol

Dmel\dlp^A187

Species

D. melanogaster

Name

FlyBase ID

FBal0155392

Feature type

allele

Associated gene

Dmel\dlp

Associated Insertion(s)

Carried in Construct

Also Known As

dly^A187

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Yao et al., 2006)

Mutagen

ethyl methanesulfonate

(Han et al., 2004)

Progenitor genotype

Cytology

Description

dlp^A187 contains a deletion of 26 nucleotides resulting in a reading frame shift from amino acid 205.

(Han et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Friedman et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | non-rescuable maternal effect

(Han et al., 2004)

lethal | larval stage

(Han et al., 2004)

lethal | recessive

(Avanesov et al., 2012)

segment polarity phenotype | embryonic stage | non-rescuable maternal effect

(Han et al., 2004)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Yan et al., 2010)

sensory mother cell | somatic clone

(Han et al., 2005)

Detailed Description

Statement

Reference

Neuromuscular junctions in dlp^A187/+ mutant larvae do not exhibit significant changes in branch number and increased type I synaptic bouton number, nor any significant difference in the amplitude of evoked junctional currents, as compared to controls.

(Friedman et al., 2013)

Homozygous embryos derived from homozygous female germline clones have a lawn of denticles phenotype with a lack of naked cuticle.

(Yan et al., 2010)

Mutant embryos do not exhibit ventral midline crossovers of ipsilateral axon fascicles.

(Chanana et al., 2009)

When homozygous mutant clones are are m made in the wing disc, ectopic sensory organ precursors are seen.

(Han et al., 2005)

Embryos laid by dlp^A187 homozygous females die with a strong segment-polarity phenotype. In contrast, zygotically homozygous dlp^A187 embryos from dlp^A187/+ mothers have normal cuticle patterning and survive until third instar larvae.

(Han et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dally⁸⁰, dlp^A187 has abnormal immune response phenotype, enhanceable by Df(2R)48

(Baron et al., 2009)

Enhancer of

Statement

Reference

dlp^A187 is an enhancer of abnormal immune response phenotype of dally⁸⁰

(Baron et al., 2009)

dlp^A187/Df(2R)48 is an enhancer of abnormal immune response phenotype of dally⁸⁰

(Baron et al., 2009)

dlp^A187 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Sdc²³

(Chanana et al., 2009)

Suppressor of

Statement

Reference

dlp[+]/dlp^A187 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fmr1^Δ50M

(Friedman et al., 2013)

dlp[+], Sdc[+], dlp^A187, Sdc²³ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fmr1^Δ50M

(Friedman et al., 2013)

dlp[+], Sdc[+], dlp^A187, Sdc²³ is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Fmr1^Δ50M

(Friedman et al., 2013)

NOT Suppressor of

Statement

Reference

dlp[+]/dlp^A187 is a non-suppressor of abnormal neurophysiology | third instar larval stage phenotype of Fmr1^Δ50M

(Friedman et al., 2013)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Lar^bypass, dlp^A187 has anterior fascicle & axon | ectopic phenotype, non-enhanceable by dally⁸⁰

(Fox and Zinn, 2005)

Suppressed by

Statement

Reference

dlp^A187 has embryonic/first instar larval cuticle phenotype, suppressible by Scer\GAL4^prd.RG1/wg^UAS.cKa

(Yan et al., 2010)

NOT suppressed by

Statement

Reference

dlp^A187 has embryonic/first instar larval cuticle phenotype, non-suppressible by Scer\GAL4^prd.RG1/hh^UAS.cIa

(Yan et al., 2010)

Enhancer of

Statement

Reference

dlp^A187 is an enhancer of fascicle | embryonic stage | ectopic phenotype of Sdc²³

(Chanana et al., 2009)

dlp^A187 is an enhancer of ventral denticle belt | embryonic stage phenotype of ihog^KG

(Yao et al., 2006)

NOT Enhancer of

Statement

Reference

dlp^A187 is a non-enhancer of anterior fascicle & axon | ectopic phenotype of Lar^bypass, dally⁸⁰

(Fox and Zinn, 2005)

dlp^A187 is a non-enhancer of sensory mother cell | ectopic | somatic clone phenotype of Notum^I6

(Han et al., 2005)

Suppressor of

Statement

Reference

dlp[+]/dlp^A187 is a suppressor of type I bouton | third instar larval stage phenotype of Fmr1^Δ50M

(Friedman et al., 2013)

dlp[+], Sdc[+], dlp^A187, Sdc²³ is a suppressor of type I bouton | third instar larval stage phenotype of Fmr1^Δ50M

(Friedman et al., 2013)

dlp[+]/dlp^A187 is a suppressor of wing phenotype of Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

dlp[+]/dlp^A187 is a suppressor of wing margin bristle phenotype of Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

NOT Suppressor of

Statement

Reference

dlp^A187 is a non-suppressor of sensory mother cell | ectopic | somatic clone phenotype of Notum^I6

(Han et al., 2005)

Other

Statement

Reference

Fmr1^Δ50M, dlp[+]/dlp^A187 has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Friedman et al., 2013)

Fmr1^Δ50M, Sdc[+]/Sdc²³, dlp[+]/dlp^A187 has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Friedman et al., 2013)

dally⁸⁰, dlp^A187 has posterior crossvein | somatic clone | cell non-autonomous phenotype

(Chen et al., 2012)

dlp^A187, ihog^e02142 has ventral denticle belt | embryonic stage phenotype

(Yao et al., 2006)

dally⁸⁰, dlp^A187 has wing vein L4 | somatic clone phenotype

(Han et al., 2004)

dally⁸⁰, dlp^A187 has wing vein L3 | somatic clone phenotype

(Han et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Neuromuscular junctions in dlp^A187/+, Sdc²³/+ double mutant larvae do not exhibit significant changes in branch number and increased type I synaptic bouton number, as compared to controls.

dlp^A187/+, or both dlp^A187/+ and Sdc²³/+, suppresses the increase in NMJ branching and synaptic bouton number; and both Sdc²³/+ and dlp^A187/+ (but not dlp^A187/+ alone) suppresses the increased amplitude of evoked junctional currents seen in Fmr1^Δ50M/Fmr1^Δ50M mutant larvae.

(Friedman et al., 2013)

Wing disc clones mutant for dally⁸⁰ and dlp^A187 often have incomplete or fragmented posterior crossveins. This effect is not cell-autonomous.

(Chen et al., 2012)

dally⁸⁰ dlp^A187 Df(2R)48 triple heterozygotes exhibit increased median survival time compared to controls when infected with group B Streptococcus (both wild-type and GAG-binding impaired mutants) and lower colony counts after infection.

(Wang et al., 2011)

Expression of wg^Scer\UAS.cKa under the control of Scer\GAL4^prd.RG1 restores naked cuticle in dlp^A187 embryos derived from dlp^A187 female germline clones.

Expression of hh^Scer\UAS.cIa under the control of Scer\GAL4^prd.RG1 does not restore naked cuticle in dlp^A187 embryos derived from dlp^A187 female germline clones.

The ability of dlp^-HS.Scer\UAS expressed under the control of Scer\GAL4^prd.RG1 to rescue naked cuticle patterning in dlp^A187 embryos derived from dlp^A187 female germline clones is not affected if the embryos are also mutant for dally⁸⁰.

(Yan et al., 2010)

dally⁸⁰ dlp^A187 double heterozygotes resist infection with wild-type group B streptococcus (to a greater extent than single mutants).

dally⁸⁰ dlp^A187 Df(2R)48 triple heterozygotes resist infection with wild-type group B streptococcus (to a greater extent than single and double mutants).

dally⁸⁰ dlp^A187 Df(2R)48 triple heterozygous mutants survive longer than wild-type flies when infected with ACP-GAG binding impaired group B streptococcus.

(Baron et al., 2009)

dlp^A187, Sdc²³ double mutant embryos show a 2-fold increase in ventral midline crossovers of axon fascicles compared to Sdc²³ single mutants.

(Chanana et al., 2009)

In contrast to zygotic iHog^KG single mutants, iHog^KG; dlp^A187 zygotic double mutants show denticle belt fusions. iHog^e02142; dlp^A187 zygotic mutants also show this phenotype.

(Yao et al., 2006)

dlp^A187, dally⁸⁰ mutants display ISNb bypass at a similar rate to wild-type embryos. The Lar^bypass ISNb phenotype is not enhanced in Lar^bypass; dlp^A187, dally⁸⁰ triple mutants.

(Fox and Zinn, 2005)

Somatic clones of dally⁸⁰; dlp^A187 doubly homozygous cells in the wing lead to L3-L4 fusion, a phenotype not seen with single mutants clones.

(Han et al., 2004)

Xenogenetic Interactions

Statement

Reference

One copy of dlp^A187 suppresses the wing defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62. Scalloping of the wing margin is almost completely eliminated and more margin bristles are retained.

(Avanesov et al., 2012)

Complementation and Rescue Data

Rescued by

dlp^A187 is rescued by Scer\GAL4^prd.RG1/dlp^UAS.cBa

(Yan et al., 2010)

dlp^A187 is rescued by Scer\GAL4^prd.RG1/dlp^{UAS.GFP,Tag:M(rCd2)}

(Yan et al., 2010)

dlp^A187 is rescued by Scer\GAL4^prd.RG1/dlp^-HS.UAS

(Yan et al., 2010)

dlp^A187 is rescued by dlp^-HS.CD2.UAS/Scer\GAL4^prd.RG1

(Yan et al., 2010)

dlp^A187 is rescued by Scer\GAL4^prd.RG1/dlp^ΔGAG.UAS

(Yan et al., 2010)

Not rescued by

dlp^A187 is not rescued by dlp^ΔN.UAS/Scer\GAL4^prd.RG1

(Yan et al., 2010)

dlp^A187 is not rescued by Scer\GAL4^prd.RG1/dlp^ΔC.UAS

(Yan et al., 2010)

Comments

Expression of dlp^-HS.Scer\UAS under the control of Scer\GAL4^prd.RG1 effectively rescues naked cuticle patterning cell-autonomously in dlp^A187 embryos derived from dlp^A187 female germline clones.

Expression of dlp^Scer\UAS.cBa under the control of Scer\GAL4^prd.RG1 restores cuticle patterning in entire segments in a non-cell-autonomous manner in dlp^A187 embryos derived from dlp^A187 female germline clones.

Expression of dlp^{ΔGAG.Scer\UAS} or dlp^{-HS.Scer\UAS.T:Rnor\CD2} under the control of Scer\GAL4^prd.RG1 rescues naked cuticle formation in dlp^A187 embryos derived from dlp^A187 female germline clones.

Expression of either dlp^ΔC.Scer\UAS or dlp^ΔN.Scer\UAS under the control of Scer\GAL4^prd.RG1 fails to rescue naked cuticle formation in dlp^A187 embryos derived from dlp^A187 female germline clones.

Expression of dlp^{Scer\UAS.T:Avic\GFP,T:Rnor\CD2} under the control of Scer\GAL4^prd.RG1 rescues naked cuticle patterning cell-autonomously in dlp^A187 embryos derived from dlp^A187 female germline clones.

(Yan et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Isolated from a deficiency screen using Df(3L)fz-M21

(Han et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dlp^A187

(Kamimura et al., 2019, Kanai et al., 2018, Dear et al., 2016, Avanesov and Blair, 2013, Friedman et al., 2013, Zhang et al., 2013, Avanesov et al., 2012, Chen et al., 2012, Wang et al., 2011, Yan et al., 2010, Baron et al., 2009, Chanana et al., 2009, Yan et al., 2009, Yan and Lin, 2007, Yao et al., 2006, Glise et al., 2005)

dly^A187

(Belenkaya et al., 2004, Han et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (22)

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