FlyBase Allele Report: Drer\wif1[UAS.cAa]

General Information

Symbol

Drer\wif1^UAS.cAa

Species

D. rerio

Name

Saccharomyces cerevisiae UAS construct of Avanesov

FlyBase ID

FBal0268249

Feature type

allele

Associated gene

Drer\wif1

Associated Insertion(s)

Carried in Construct

P{UAS-wif1.A}

Also Known As

UAS-wif1

Transgenic product class

wild_type

(Avanesov et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Avanesov et al., 2012)

Mutagen

in vitro construct

(Avanesov et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-wif1.A}

Cytology

Description

UAS regulatory sequences drive expression of full length Drer\wif1.

(Avanesov et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Drer\wif1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^en-e16E

(Avanesov et al., 2012)

Phenotype Manifest In

wing, with Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

wing margin bristle | anterior, with Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

wing vein L1, with Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Detailed Description

Statement

Reference

Expression of Drer\wif1^Scer\UAS.cAa under the control of Scer\GAL4^nub-AC-62 produces adult wing phenotypes. many anterior bristles are eliminated, the first longitudinal vein is disrupted and the wing is somewhat reduced in size.

Expression of Drer\wif1^Scer\UAS.cAa under the control of Scer\GAL4^en-e16E is completely lethal. No escapers are seen.

(Avanesov et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62, shf² has lethal | pupal stage phenotype

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62, shf^x33 has lethal | pupal stage phenotype

(Avanesov et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing phenotype, enhanceable by dlp^UAS.cBa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing margin bristle phenotype, enhanceable by dlp^UAS.cBa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing phenotype, enhanceable by dally^UAS.cJa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing margin bristle phenotype, enhanceable by dally^UAS.cJa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Suppressed by

Statement

Reference

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing phenotype, suppressible by dlp[+]/dlp^A187

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing margin bristle phenotype, suppressible by dlp[+]/dlp^A187

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing phenotype, suppressible by dlp^GD3592, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing margin bristle phenotype, suppressible by dlp^GD3592, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing phenotype, suppressible | partially by dally⁸⁰/dally[+]

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing margin bristle phenotype, suppressible | partially by dally⁸⁰/dally[+]

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing phenotype, suppressible | partially by shf^UAS.cGb, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 has wing margin bristle phenotype, suppressible | partially by shf^UAS.cGb, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Enhancer of

Statement

Reference

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62 is an enhancer of wing phenotype of Scer\GAL4^nub-AC-62, fz2^{GPI.UAS.Tag:MYC}

(Avanesov et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of dlp^Scer\UAS.cBa strongly enhances the wing scalloping and bristle loss phenotypes seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62.

Expression of Drer\wif1^Scer\UAS.cAa enhances the reduction in adult wing size seen when fz2^{GPI.Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^nub-AC-62.

One copy of dlp^A187 suppresses the wing defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62. Scalloping of the wing margin is almost completely eliminated and more margin bristles are retained.

Expression of dlp^GD3592 suppresses the wing defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62. Scalloping of the wing margin is almost completely eliminated and more margin bristles are retained.

Expression of dally^Scer\UAS.cJa synergistically enhances the wing defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62. Wing margin bristles and the first longitudinal vein are almost completely eliminated. Wing size is further reduced.

One copy of dally⁸⁰ partially suppresses the wing margin defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62.

Expression of shf^Scer\UAS.cGb partially suppresses the adult wing defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62. The amount of wing margin notching is reduced and the first longitudinal vein and some anterior bristles are restored.

Expression of Drer\wif1^Scer\UAS.cAa under the control of Scer\GAL4^nub-AC-62 in a shf^x33 mutant background is lethal at the pupal stage.

Expression of Drer\wif1^Scer\UAS.cAa under the control of Scer\GAL4^nub-AC-62 in a shf² mutant background is lethal at the pupal stage.

(Avanesov et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Drer\wif1^Scer\UAS.cAa

Drer\wif1^UAS.cAa

Name Synonyms

Saccharomyces cerevisiae UAS construct of Avanesov

Secondary FlyBase IDs

References (2)

Report Sections

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