FB2024_03 , released June 25, 2024
Allele: Dmel\fz2GPI.UAS.Tag:MYC
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General Information
Symbol
Dmel\fz2GPI.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0122978
Feature type
allele
Associated gene
Dmel\fz2
Associated Insertion(s)
Carried in Construct
P{UAS-fz2.GPI}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rulifson et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-fz2.GPI}
Cytology
Description

UAS regulatory sequences drive expression of fz2 with a GPI membrane anchor and tagged with Tag:MYC.

(Rulifson et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fz2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of fz2GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nub-AC-62 produces adult wing phenotypes. Wings lack all margin bristles and show extreme notching of the wing margin and reduced wing size.

      (Avanesov et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Scer\GAL4nub-AC-62, fz2GPI.UAS.Tag:MYC has wing phenotype, non-enhanceable by dlpUAS.cBa/Scer\GAL4nub-AC-62

      (Avanesov et al., 2012)
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of dlpScer\UAS.cBa does not enhance the reduction in adult wing size seen when fz2GPI.Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4nub-AC-62.

      (Avanesov et al., 2012)

      Clones of cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) that are expressing fz2GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4αTub84B.PL in a dsunspecified background do not change the cell polarity of cells surrounding the clone.

      (Casal et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Drer\wif1Scer\UAS.cAa enhances the reduction in adult wing size seen when fz2GPI.Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4nub-AC-62.

      Expression of shfScer\UAS.cGb partially suppresses the adult wing margin defects seen when fz2GPI.Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4nub-AC-62.

      (Avanesov et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fz2GPI.Scer\UAS.T:Hsap\MYC
      (Casal et al., 2006)
      fz2GPI.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)