FlyBase Allele Report: Dmel\shf[x33]

General Information

Symbol

Dmel\shf^x33

Species

D. melanogaster

Name

FlyBase ID

FBal0240344

Feature type

allele

Associated gene

Dmel\shf

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Glise et al., 2005)

Progenitor genotype

Cytology

Description

Imprecise excision of a P-element has deleted 630 bp, including the exon 2 acceptor splice site, the ATG, and the sequence coding for the first 32 amino acids of the Shf protein, including the signal peptide.

(Glise et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Glise et al., 2005)

Phenotype Manifest In

1st posterior cell

(Glise et al., 2005)

eye

(Glise et al., 2005)

scutellar bristle

(Glise et al., 2005)

scutellum

(Glise et al., 2005)

wing

(Avanesov et al., 2012)

wing vein L3

(Avanesov et al., 2012, Glise et al., 2005)

wing vein L4

(Avanesov et al., 2012)

Detailed Description

Statement

Reference

In shf^x33 mutant adult wings the spacing between the third and fourth longitudinal vein is greatly reduced.

(Avanesov et al., 2012)

The wings of shf^x33 hemizygous adults have a reduced distance between L3 and L4 and sometimes have partial deletions of L3. Their eyes and scutellum are also reduced. The scutellum usually lacks bristles.

(Glise et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62, shf^x33 has lethal | pupal stage phenotype

(Avanesov et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

shf^x33 has wing phenotype, suppressible by shf::Drer\wif1^{EDF-WIF.UAS.Tag:V5}

(Avanesov et al., 2012)

shf^x33 has wing vein L3 phenotype, suppressible by shf::Drer\wif1^{EDF-WIF.UAS.Tag:V5}

(Avanesov et al., 2012)

shf^x33 has wing vein L4 phenotype, suppressible by shf::Drer\wif1^{EDF-WIF.UAS.Tag:V5}

(Avanesov et al., 2012)

shf^x33 has wing phenotype, suppressible | partially by shf::Drer\wif1^{WIF-EDF.UAS.Tag:V5}

(Avanesov et al., 2012)

shf^x33 has wing vein L3 phenotype, suppressible | partially by shf::Drer\wif1^{WIF-EDF.UAS.Tag:V5}

(Avanesov et al., 2012)

shf^x33 has wing vein L4 phenotype, suppressible | partially by shf::Drer\wif1^{WIF-EDF.UAS.Tag:V5}

(Avanesov et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of shf::Drer\wif1^{EDF-WIF.Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^en-e16E strongly suppresses the wing vein phenotype seen in shf^x33/Y mutants.

Expression of shf::Drer\wif1^{WIF-EDF.Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^en-e16E weakly suppresses the wing vein phenotype seen in shf^x33/Y mutants.

Expression of Drer\wif1^Scer\UAS.cAa under the control of Scer\GAL4^nub-AC-62 in a shf^x33 mutant background is lethal at the pupal stage.

(Avanesov et al., 2012)

Complementation and Rescue Data

Rescued by

shf^x33 is rescued by Scer\GAL4^en-e16E/shf^UAS.cGb

(Glise et al., 2005)

shf^x33 is rescued by shf^UAS.cGb/Scer\GAL4^dpp.blk1

(Glise et al., 2005)

shf^x33 is rescued by Scer\GAL4^ptc-559.1/shf^UAS.cGb

(Glise et al., 2005)

shf^x33 is rescued by shf^UAS.cGb/Scer\GAL4^ap-md544