FB2024_03 , released June 25, 2024
Allele: Dmel\shf::Drerwif1EDF-WIF.UAS.Tag:V5
Open Close
General Information
Symbol
Dmel\shf::Drer\wif1EDF-WIF.UAS.Tag:V5
Species
D. melanogaster
Name
FlyBase ID
FBal0268253
Feature type
allele
Associated gene
shf::Drer\wif1
Associated Insertion(s)
Carried in Construct
P{UAS-shf::wif1.EDF-WIF.V5}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Avanesov et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-shf::wif1.EDF-WIF.V5}
Cytology
Description

UAS regulatory sequences drive expression of a chimeric construct containing the shf EDF-like domain and the Drer\wif1 WIF domain. The junction is at T[174]: Q[261]. The construct is tagged with Tag:V5.

(Avanesov et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
shf::Drer\wif1
Tagged with
Tag:V5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of shf::Drer\wif1EDF-WIF.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4nub-AC-62 produces adult wing phenotypes. Anterior bristles are eliminated, the first longitudinal vein is disrupted and the wing is somewhat reduced in size.

      Expression of shf::Drer\wif1EDF-WIF.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4en-e16Eis largely lethal but adult escapers are seen.

      (Avanesov et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of dlpScer\UAS.cBa synergistically enhances the wing scalloping and bristle loss phenotypes seen when shf::Drer\wif1EDF-WIF.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4nub-AC-62. Wing margin bristles and the first longitudinal vein are almost completely eliminated and wing size is further reduced.

      Expression of shf::Drer\wif1EDF-WIF.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4en-e16E strongly suppresses the wing vein phenotype seen in shfx33/Y mutants.

      (Avanesov et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      shf::Drer\wif1EDF-WIF.Scer\UAS.T:SV5\V5
      shf::Drer\wif1EDF-WIF.UAS.Tag:V5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)