FlyBase Allele Report: Dmel\flw[UAS.Tag:HA]

General Information

Symbol

Dmel\flw^UAS.Tag:HA

Species

D. melanogaster

Name

FlyBase ID

FBal0150498

Feature type

allele

Associated gene

Dmel\flw

Associated Insertion(s)

Carried in Construct

P{UAS-flw.HA}

Also Known As

UAS-HA-PP1β9C, UAS-PP1β9C, UAS-flw-HA

Key Links

Transgenic product class

wild_type

(Bennett et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Bennett et al., 2003)

Mutagen

in vitro construct

(Bennett et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-flw.HA}

Cytology

Description

UAS regulatory sequences drive expression of flw.

(Bennett et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

flw

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

flw^UAS.Tag:HA/Scer\GAL4^332.3 is a suppressor of majority die during embryonic stage phenotype of crb^GX24w-/crb^11A22, crb^Y10A

(Flores-Benitez and Knust, 2015)

flw^UAS.Tag:HA/Scer\GAL4^Act.PU is a suppressor | somatic clone of visible | somatic clone phenotype of sds22^e00975

(Jiang et al., 2011)

flw^UAS.Tag:HA/Scer\GAL4^arm.PS is a suppressor of lethal phenotype of Pp1-87B^87Bg-3/Pp1-87B¹

(Kirchner et al., 2007)

flw^UAS.Tag:HA, Scer\GAL4^arm.PS is a suppressor of lethal phenotype of NiPp1^UAS.EGFP, Scer\GAL4^arm.PS

(Parker et al., 2002)

flw^UAS.Tag:HA, Scer\GAL4^Bx-MS1096 is a suppressor of visible phenotype of NiPp1^UAS.EGFP, Scer\GAL4^Bx-MS1096

(Parker et al., 2002)

NOT Suppressor of

Statement

Reference

flw^UAS.Tag:HA/Scer\GAL4^arm.PS is a non-suppressor of lethal phenotype of Pp1α-96A², Pp1-87B^87Bg-3/Pp1-87B¹

(Kirchner et al., 2007)

flw^UAS.Tag:HA/flw¹, Scer\GAL4^arm.PS is a non-suppressor of viable phenotype of Nop17l^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^arm.PS

(Bennett et al., 2006)

Other

Statement

Reference

NiPp1^UAS.EGFP, Scer\GAL4^arm.PS, flw^UAS.Tag:HA has viable phenotype

(Parker et al., 2002)

Phenotype Manifest In

Suppressor of

Statement

Reference

flw^UAS.Tag:HA/Scer\GAL4^332.3 is a suppressor | partially of embryo | dorsal closure stage phenotype of crb^GX24w-/crb^11A22, crb^Y10A

(Flores-Benitez and Knust, 2015)

flw^UAS.Tag:HA/Scer\GAL4^Act.PU is a suppressor | somatic clone of eye | somatic clone phenotype of sds22^e00975

(Jiang et al., 2011)

flw^UAS.Tag:HA, Scer\GAL4^arm.PS is a suppressor of indirect flight muscle cell phenotype of NiPp1^UAS.Tag:HA, Scer\GAL4^arm.PS

(Bennett et al., 2003)

flw^UAS.Tag:HA, Scer\GAL4^Bx-MS1096 is a suppressor of wing phenotype of NiPp1^UAS.EGFP, Scer\GAL4^Bx-MS1096

(Parker et al., 2002)

Other

Statement

Reference

Scer\GAL4^332.3, crb^GX24w-/crb^11A22, crb^Y10A, flw^UAS.Tag:HA has embryonic dorsal epidermis phenotype

(Flores-Benitez and Knust, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of flw^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^332.3 largely suppresses the embryonic lethality and dorsal closure defects in embryos expressing crb^Y10A in a crb^GX24w-/crb^11A22 background, although some embryos exhibit irregular zippering at the posterior canthus and bunching of the epidermis.

Expression of flw^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^332.3 does not lead to any obvious phenotype in embryos expressing crb^+tfos in a crb^GX24w-/crb^11A22 background.

Expression of flw^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^332.3 does not lead to any obvious phenotype in embryos expressing crb^Y10F in a crb^GX24w-/crb^11A22 background.

(Flores-Benitez and Knust, 2015)

Expression of flw^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU significantly suppresses the eye defects seen in mosaic flies with eyes that are homozygous for sds22^e00975.

(Jiang et al., 2011)

The synthetic lethality resulting from the overexpression of Nop17l^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} under the control of Scer\GAL4^arm.PS in a hemizygous flw¹ mutant background can be rescued by the co-expression of flw^{Scer\UAS.T:Ivir\HA1}.

(Bennett et al., 2006)

The indirect flight muscles are restored in adults expressing NiPp1^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^arm.PS if they are also expressing flw^{Scer\UAS.T:Ivir\HA1}.

(Bennett et al., 2003)

The wing defects caused by expression of NiPp1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Bx-MS1096 are almost completely suppressed by co-expression of flw^{Scer\UAS.T:Ivir\HA1}.

(Parker et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

flw^UAS.Tag:HA/Scer\GAL4^{flw-MI10323-TG4.1} rescues flw^{MI10323-TG4.1}

(Lee et al., 2018)

flw^UAS.Tag:HA/Scer\GAL4^e22c rescues flw^FP41

(Sun et al., 2011)

flw^UAS.Tag:HA/Scer\GAL4^arm.PS rescues flw⁶

(Kirchner et al., 2007)

Comments

Expression of flw^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^e22c rescues the oocyte polarity defects seen when the posterior follicle cells are mutant for flw^FP41.

(Sun et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

23702

w^*; P{UAS-flw.HA}3

23703

w^*; P{UAS-flw.HA}2

Notes on Origin

Discoverer