FB2024_03 , released June 25, 2024
Allele: Dmel\Nop17lUAS.Tag:polyHis,Tag:MYC
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General Information
Symbol
Dmel\Nop17lUAS.Tag:polyHis,Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0264830
Feature type
allele
Associated gene
Dmel\Nop17l
Associated Insertion(s)
Carried in Construct
P{UAS-Nop17l.HM}
Key Links
Transgenic product class
wild_type
(Bennett et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bennett et al., 2006)
Mutagen
in vitro construct
(Bennett et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Nop17l.HM}
Cytology
Description

UAS regulatory sequences drive expression of Nop17l tagged with Tag:polyHis and two copies of Tag:MYC.

(Bennett et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nop17l
Tagged with
Tag:MYC
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC in the wing under the control of Scer\GAL4Bx-MS1096 results in a modest reduction in tissues size and occasional loss of the posterior wing margin.

      Ubiquitous expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4arm.PS has no detectable effect on viability and adults phenotypically resemble wild-type.

      (Bennett et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Nop17lUAS.Tag:polyHis,Tag:MYC, Scer\GAL4arm.PS has viable phenotype, suppressible by flw1

      (Bennett et al., 2006)

      Nop17lUAS.Tag:polyHis,Tag:MYC, Scer\GAL4arm.PS has viable phenotype, suppressible by Pp1-87B87Bg-3/Pp1-87B[+]

      (Bennett et al., 2006)
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 in hemizygous flw1 mutant wings results in severely crumpled and reduced wings.

      Expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 in Pp1-87B1/+ wings results in severely crumpled and reduced wings.

      Expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 in Pp1-87B87Bg-3/+ wings results in severely crumpled and reduced wings.

      Expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4arm.PS is synthetic lethal in a heterozygous Pp1-87B87Bg-3 mutant background.

      Expression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4arm.PS is synthetic lethal in a hemizygous flw1 mutant background.

      The synthetic lethality resulting from the overexpression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4arm.PS in a hemizygous flw1 mutant background can be rescued by the co-expression of flwScer\UAS.T:Ivir\HA1.

      The synthetic lethality resulting from the overexpression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4arm.PS in a heterozygous Pp1-87B87Bg-3 mutant background can be rescued by the co-expression of Pp1-87BScer\UAS.T:Ivir\HA1.

      (Bennett et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC
      Nop17lUAS.Tag:polyHis,Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)