FlyBase Allele Report: Dmel\NiPp1[UAS.EGFP]

General Information

Symbol

Dmel\NiPp1^UAS.EGFP

Species

D. melanogaster

Name

FlyBase ID

FBal0156151

Feature type

allele

Associated gene

Dmel\NiPp1

Associated Insertion(s)

Carried in Construct

P{UAS-EGFP-NiPp1}

Also Known As

UAS-NiPp1

Key Links

Transgenic product class

wild_type

(Parker et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parker et al., 2002)

Mutagen

in vitro construct

(Parker et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-EGFP-NiPp1}

Cytology

Description

UAS regulatory sequences drive expression of the complete NiPp1 coding sequence tagged with EGFP.

(Parker et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

NiPp1

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm | adult stage, with Scer\GAL4^Pdf.PU

(Xue et al., 2019)

abnormal circadian rhythm | adult stage, with Scer\GAL4^tim.UAS

(Xue et al., 2019)

lethal, with Scer\GAL4^arm.PS

(Parker et al., 2002)

lethal, with Scer\GAL4^how-24B

(Parker et al., 2002)

lethal, with Scer\GAL4^hs.PB

(Parker et al., 2002)

lethal, with Scer\GAL4^tim.PU

(Xue et al., 2019)

visible, with Scer\GAL4^Bx-MS1096

(Parker et al., 2002)

Phenotype Manifest In

embryonic/larval optic lobe, with Scer\GAL4^GMR.PF

(Babu et al., 2005)

photoreceptor cell R1 & axon, with Scer\GAL4^GMR.PF

(Babu et al., 2005)

photoreceptor cell R2 & axon, with Scer\GAL4^GMR.PF

(Babu et al., 2005)

photoreceptor cell R3 & axon, with Scer\GAL4^GMR.PF

(Babu et al., 2005)

photoreceptor cell R4 & axon, with Scer\GAL4^GMR.PF

(Babu et al., 2005)

photoreceptor cell R5 & axon, with Scer\GAL4^GMR.PF

(Babu et al., 2005)

wing, with Scer\GAL4^Bx-MS1096

(Parker et al., 2002)

Detailed Description

Statement

Reference

Expressing NiPp1^UAS.EGFP under the control of either Scer\GAL4^tim.UAS or Scer\GAL4^Pdf.PU show lengthened circadian periods.

(Xue et al., 2019)

Expression of NiPp1^{Scer\UAS.T:Avic\GFP-EGFP} in the eye disc, driven by Scer\GAL4^GMR.PF, does not affect eye disc morphology but causes mistargeting of axons R2-R5 into the medulla and axonal breaks in the lamina.

(Babu et al., 2005)

Expression of NiPp1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Bx-MS1096 results in a severe loss of wing tissue and the wings are severely crumpled. Wings of animals expressing NiPp1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^vg.PM resemble wild type.

(Parker et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

NiPp1^UAS.EGFP, Scer\GAL4^arm.PS has lethal phenotype, suppressible by Pp1α-96A^UAS.Tag:HA, Scer\GAL4^arm.PS

(Parker et al., 2002)

NiPp1^UAS.EGFP, Scer\GAL4^arm.PS has lethal phenotype, suppressible by Pp1-13C^UAS.Tag:HA, Scer\GAL4^arm.PS