FB2024_03 , released June 25, 2024
Allele: Dmel\NiPp1UAS.Tag:HA
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General Information
Symbol
Dmel\NiPp1UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0150725
Feature type
allele
Associated gene
Dmel\NiPp1
Associated Insertion(s)
Carried in Construct
P{UAS-NiPp1.HA}
Also Known As
UAS-nipp1, UAS-HA-nipp1
Key Links
Transgenic product class
wild_type
(Bennett et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bennett et al., 2003)
Mutagen
in vitro construct
(Bennett et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-NiPp1.HA}
Cytology
Description

UAS regulatory sequences drive expression of NiPp1.

(Bennett et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
NiPp1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing NiPp1UAS.EGFP under the control of either Scer\GAL4tim.UAS or Scer\GAL4Pdf.PU show lengthened circadian periods.

      (Xue et al., 2019)

      Files expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4P2.4.Pdf have a locomotor activity period approximately 1.5 hours longer than that of controls.

      Files expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tim.Scer\UAS have a locomotor activity period approximately 2.8 hours longer than that of controls. In addition, the amplitude of the circadian rhythm is reduced. These flies show long period rhythms that degenerate into arrhythmia after 4-6 days under constant darkness conditions.

      The amplitude of phase shifts and the effective duration of the phase delay domain is increased in flies expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tim.Scer\UAS compared to wild type when the phase response curve for light is examined. The phase delay-to-phase advance transition point occurs approximately 2 hours later than in controls, but the phase advance domains are about the same duration as in controls.

      (Fang et al., 2007)

      More than 95% of animals expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS die either before or just after pupation. Squash preparations of third larval instar brains contain fewer cells per microscope field than normal and a significantly higher proportion of cells in mitosis than in wild type. Overcondensed chromosomes are seen. Indirect flight muscles are either not present or are in complete disarray in the few adult survivors expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS. The jump muscle is mostly normal. Flies expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4vg.PM resemble wild type.

      (Bennett et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Enhancer of
      Statement
      Reference

      NiPp1UAS.Tag:HA, Scer\GAL4vg.PM is an enhancer of visible phenotype of Scer\GAL4vg.PM, putUAS.cMa

      (Bennett et al., 2003)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      NiPp1UAS.Tag:HA, Scer\GAL4arm.PS has mitosis & nuclear chromosome phenotype, enhanceable by I-2UAS.Tag:polyHis,Tag:MYC, Scer\GAL4arm.PS

      (Bennett et al., 2003)
      Suppressed by
      Enhancer of
      Statement
      Reference

      NiPp1UAS.Tag:HA, Scer\GAL4vg.PM is an enhancer of wing phenotype of Scer\GAL4vg.PM, putUAS.cMa

      (Bennett et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Files coexpressing sggScer\UAS.cBa and NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tim.Scer\UAS have an average locomotor activity period of 19.5 hours, approximately 1.3 hours longer than that of flies expressing sggScer\UAS.cBa alone under the control of Scer\GAL4tim.Scer\UAS.

      (Fang et al., 2007)

      Co-expression of I-2Scer\UAS.T:Zzzz\His6,T:Hsap\MYC enhances the mitotic defects seen in larvae expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS. The indirect flight muscles are restored in adults expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS if they are also expressing flwScer\UAS.T:Ivir\HA1. The modest wing overgrowth phenotype caused by expression of putScer\UAS.cMa under the control of Scer\GAL4vg.PM is enhanced by co-expression of NiPp1Scer\UAS.T:Ivir\HA1.

      (Bennett et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NiPp1Scer\UAS.T:Ivir\HA1
      NiPp1UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (10)