FlyBase Allele Report: Dmel\fru[AJ96u3]

General Information

Symbol

Dmel\fru^AJ96u3

Species

D. melanogaster

Name

FlyBase ID

FBal0144305

Feature type

allele

Associated gene

Dmel\fru

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Song et al., 2002)

Mutagen

P-element activity

(Song et al., 2002)

Progenitor genotype

P{lacZ}AJ96

(Song et al., 2002)

Caused by aberration

Df(3R)fru^AJ96u3

Cytology

Description

Deletion extending from sequences within the P{lacZ}AJ96 element to sequences between the fru P3 and P4 promoters.

(Song et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior (with fru^4-40)

(Chen et al., 2021)

abnormal courtship behavior | male (with fru^GAL4.P1.D)

(Stockinger et al., 2005)

abnormal neuroanatomy (with fru^P14)

(Song et al., 2002)

abnormal neuroanatomy (with fru^sat15)

(Song et al., 2002)

abnormal neuroanatomy (with fru^w12)

(Song et al., 2002)

lethal | prepupal stage (with Df(3R)fru^w24)

(Song et al., 2002)

lethal | prepupal stage | recessive

(Song et al., 2002)

lethal | pupal stage (with Df(3R)fru^w24)

(Song et al., 2002)

lethal | pupal stage | recessive

(Song et al., 2002)

lethal - all die before end of prepupal stage (with fru^P14)

(Song et al., 2002)

lethal - all die before end of prepupal stage (with fru^sat15)

(Song et al., 2002)

lethal - all die before end of P-stage (with Df(3R)Exel6179)

(Cande et al., 2014)

lethal - all die before end of pupal stage (with fru^w12)

(Song et al., 2002)

lethal - all die before end of pupal stage (with fru^w27)

(Song et al., 2002)

male sterile (with fru^4-40)

(Song et al., 2002)

male sterile (with fru⁴)

(Song et al., 2002)

semi-fertile | male (with fru^GAL4.P1.D)

(Stockinger et al., 2005)

some die during prepupal stage | recessive (with fru^P14)

(Song et al., 2002)

some die during prepupal stage | recessive (with fru^sat15)

(Song et al., 2002)

some die during pupal stage (with fru^w12)

(Song et al., 2002)

some die during pupal stage (with fru^w27)

(Song et al., 2002)

viable (with fru^4-40)

(Song et al., 2002)

viable (with fru⁴)

(Song et al., 2002)

Phenotype Manifest In

anterior scutellar bristle (with fru^w27)

(Song et al., 2002)

larval longitudinal connective (with fru^P14)

(Song et al., 2002)

larval longitudinal connective (with fru^sat15)

(Song et al., 2002)

larval longitudinal connective (with fru^w12)

(Song et al., 2002)

leg joint (with fru^w27)

(Song et al., 2002)

presumptive embryonic/larval central nervous system (with fru^P14)

(Song et al., 2002)

presumptive embryonic/larval central nervous system (with fru^sat15)

(Song et al., 2002)

sternopleural bristle (with fru^w27)

(Song et al., 2002)

wing (with fru^w27)

(Song et al., 2002)

Detailed Description

Statement

Reference

fru^AJ96u3/Df(3R)Exel6179 are pupal lethal.

(Cande et al., 2014)

The male-female courtship index and fertility of fru^GAL4/fru^AJ96u3 males is significantly reduced compared to wild-type. These males court single wild-type males and form chains with males of their own genotype.

(Stockinger et al., 2005)

34% of fru^AJ96u3/fru^w12 animals die at midpupal stages (P5-P13). 56% can emerge if dissected from the pupal case. 53% of fru^AJ96u3/fru^w27 animals can emerge if dissected from the pupal case. These flies have a number of defects including uneverted discs, uninflated wings, abnormal wing position, defective leg joints and duplicated anterior scutellar or sternopleural bristles. 96% of homozygotes die at prepupal stages P4(i)-P4(ii). 14.4% of fru^w12/fru^AJ96u3 embryos have abnormal Fas2-positive fascicles in the central nervous system. 15.8% of fru^sat15/fru^AJ96u3 embryos have abnormal Fas2-positive fascicles and 17.4% have defects in the distribution and pattern of BP102-positive axons in the central nervous system. 24.5% of fru^AJ96u3/fru^P14 embryos have abnormal Fas2-positive fascicles and 17.0% have defects in the distribution and pattern of BP102-positive axons in the central nervous system.

(Song et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

fru^AJ96u3, numb^Ex112/numb¹⁵ has increased cell number phenotype, suppressible by Scer\GAL4^GMR9D11, mam^DN.UAS.cUa/mam^DN.UAS.cUa

(Rajan et al., 2023)

fru^AJ96u3, numb^Ex112/numb¹⁵ has increased cell number phenotype, suppressible by E(spl)mγ-HLH^JF02000/Scer\GAL4^GMR9D11

(Rajan et al., 2023)

fru^AJ96u3/Df(3R)Exel6179 has lethal - all die before end of P-stage phenotype, suppressible by Dana\fru^+t20H8

(Cande et al., 2014)

fru^AJ96u3/Df(3R)Exel6179 has lethal - all die before end of P-stage phenotype, suppressible by Dper\fru^+t36N18

(Cande et al., 2014)

Enhancer of

Statement

Reference

fru^AJ96u3 is an enhancer of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^AJ96u3 is an enhancer of increased cell number phenotype of brat^DG19310/brat¹¹

(Rajan et al., 2023)

fru^AJ96u3/fru^ΔC is an enhancer of increased cell number phenotype of brat^DG19310/brat¹¹

(Rajan et al., 2023)

fru^AJ96u3/fru^ΔC is an enhancer of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

NOT Enhancer of

Statement

Reference

fru^AJ96u3/fru^ΔA is a non-enhancer of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^ΔB/fru^AJ96u3 is a non-enhancer of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^AJ96u3/fru^4-40 is a non-enhancer of abnormal courtship behavior | female phenotype of retn^z2-428/retn⁰⁵⁰⁹⁶

(Ditch et al., 2005)

NOT Suppressor of

Statement

Reference

fru^AJ96u3/fru^ΔA is a non-suppressor of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^ΔB/fru^AJ96u3 is a non-suppressor of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^AJ96u3/fru^4-40 is a non-suppressor of abnormal courtship behavior | female phenotype of retn^z2-428/retn⁰⁵⁰⁹⁶

(Ditch et al., 2005)

Other

Statement

Reference

fru^AJ96u3, numb^Ex112/numb¹⁵ has increased cell number phenotype

(Rajan et al., 2023)

Dper\dsx^+t31M5, Dper\fru^+t36N18, dsx^Δ/dsx¹, fru^P1.LexA/fru^AJ96u3 has abnormal song phenotype

(Cande et al., 2014)

fru^AJ96u3, sprd⁰⁵²⁸⁴ has viable phenotype

(Song et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

fru^AJ96u3, numb^Ex112/numb¹⁵ has type II neuroblast | increased number phenotype, suppressible by E(spl)mγ-HLH^JF02000/Scer\GAL4^GMR9D11

(Rajan et al., 2023)

fru^AJ96u3, numb^Ex112/numb¹⁵ has type II neuroblast | increased number phenotype, suppressible by Scer\GAL4^GMR9D11, mam^DN.UAS.cUa/mam^DN.UAS.cUa

(Rajan et al., 2023)

Enhancer of

Statement

Reference

fru^AJ96u3 is an enhancer of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^AJ96u3 is an enhancer of neuroblast | increased number phenotype of brat^DG19310/brat¹¹

(Rajan et al., 2023)

fru^AJ96u3/fru^ΔC is an enhancer of neuroblast | increased number phenotype of brat^DG19310/brat¹¹

(Rajan et al., 2023)

fru^AJ96u3/fru^ΔC is an enhancer of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

NOT Enhancer of

Statement

Reference

fru^ΔB/fru^AJ96u3 is a non-enhancer of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^AJ96u3/fru^ΔA is a non-enhancer of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

NOT Suppressor of

Statement

Reference

fru^AJ96u3/fru^ΔA is a non-suppressor of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

fru^ΔB/fru^AJ96u3 is a non-suppressor of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

Other

Statement

Reference

fru^AJ96u3, numb^Ex112/numb¹⁵ has type II neuroblast | increased number phenotype

(Rajan et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The pupal lethality of fru^AJ96u3/Df(3R)Exel6179 mutants is rescued by combination with either Dana\fru^+t20H8 or Dper\fru^+t36N18, the emerging transgenic rescue males are fertile and sing courtship song like Drosophila melanogaster with alternating bouts of pulse and sine song (no species-specific song interconversion).

dsx¹ fru^P1.LexA/dsx^Δ fru^AJ96u3 double mutants rescued with Dana\dsx^+t21E22 and Dana\fru^+t20H8 also sing like melanogaster with both pulse and sine song elements present, wheres mutants rescued with Dper\dsx^+t31M5 and Dper\fru^+t36N18 only sing normal-pulse song but not the sine song (but still do not display any evidence of cross-species song interconversion).

(Cande et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: sprd⁰⁵²⁸⁴.

(Song et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fru^AJ96u3

(Rajan et al., 2023, Chen et al., 2021, Cande et al., 2014, Shirangi et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (8)

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