FlyBase Allele Report: Dmel\Stat92E[85C9]

Stat92E^85C9 somatic clones in the posterior compartment of third instar larval wing discs (within a Minute background, for growth advantage) are significantly smaller and less frequent, as compared to either wild-type control clones or mutant clones in the anterior compartment.

(Recasens-Alvarez et al., 2017)

Stat92E^85C9 heterozygotes do no show any obvious defects in the adult eye compared to controls.

(Clemente-Ruiz et al., 2016)

The eyes of Stat92E^85C9 mutant flies show a mild but significant reduction in eye size.

(Wang et al., 2014)

30% of Stat92E^85C9/Df(3R)H-B79 animals die during embryogenesis and the remainder die during the first larval instar.

Mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E^85C9 show a small or ablated eye phenotype.

Expression of Stat92E^{Y711F.Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{R442A.Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{R442K.Scer\UAS.P\T.T:Ivir\HA1} or Stat92E^{R442P.Scer\UAS.P\T.T:Ivir\HA1} under the control of Scer\GAL4^tub.PU exacerbates the lethality of Stat92E^85C9 homozygotes, such that a greater fraction of animals die during the embryonic stage.

(Ekas et al., 2010)

Few escapers with eye-antennal disc Stat92E^85C9 clones (in the Minute background) exhibit excess head cuticle, reduction of the eye field, partial or complete loss of antennal segments when compared to controls.

(Flaherty et al., 2010)

Wild type eyes containing Stat92E^85C9 mutant clones are normal in size. Eyes containing Stat92E^85C9 mutant clones in a Minute background are small compared with Minute controls. Elimination of cells adjacent to Stat92E^85C9 mutant clones (using hid) also results in reduced eye size.

(Wu et al., 2010)

Very few Stat92E^85C9 mutant cyst progenitor cell clones are recovered compared to controls.

(Leatherman and DiNardo, 2008)

Less than 10% of animals carrying Stat92E^85C9 clones in a Minute background eclose. Non-eclosed pupae are frequently headless or exhibit severe eye defects with expansion of the head cuticle. The few adults that eclose have small or ablated eyes and abnormal head cuticle. Stat92E^85C9 clones generated in a non-Minute background that are within the eye field develop into ectopic head cuticle or form ambiguous outgrowths.

Eye discs that contain Stat92E^85C9 Minute clones show phenotypes that are consistent with those seen in the adult head: the dorsal domain of the disc is morphologically abnormal and has protrusions, an elongated appearance and an ectopic eye field. In 5% of these discs, the morphogenetic furrow fails to initiate and in 85% of discs the furrow only moves through the ventral part of the disc.

(Ekas et al., 2006)

Homozygous mutant mosaic egg chambers display severe border cell migration defects. Border cells frequently fail to penetrate into the nurse cell clusters and can be found at the anterior tip or along the sides of the egg chamber. Alternatively the cells migrate partially, but fail top reach the oocyte by stage 10.

(Silver and Montell, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Stat92E^85C9 has lethal | somatic clone | pupal stage phenotype, suppressible by wg[+]/wg^l-16

(Ekas et al., 2006)

Enhancer of

Statement

Reference

Stat92E^85C9/Stat92E[+] is an enhancer of abnormal size | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Stat92E^85C9/Stat92E[+] is an enhancer of visible phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Stat92E^85C9/Stat92E[+] is an enhancer of visible | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Stat92E^85C9/Stat92E[+] is an enhancer of visible phenotype of upd3^x21b

(Wang et al., 2014)

Stat92E^85C9/Stat92E[+] is an enhancer of visible phenotype of upd3^d232a

(Wang et al., 2014)

NOT Enhancer of

Statement

Reference

Stat92E^85C9/Stat92E[+] is a non-enhancer of visible phenotype of upd3^x21b

(Wang et al., 2014)

Stat92E^85C9/Stat92E[+] is a non-enhancer of visible phenotype of upd3^d232a

(Wang et al., 2014)

Suppressor of

Statement

Reference

Stat92E^85C9/Stat92E[+] is a suppressor of visible | somatic clone | heat sensitive phenotype of Uba1^D6

(Lee et al., 2008)

Stat92E^85C9/Stat92E[+] is a suppressor of abnormal size | adult stage phenotype of Uba1^D6

(Lee et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Stat92E^85C9 has cuticle & adult external head | somatic clone phenotype, suppressible by wg[+]/wg^l-16

(Ekas et al., 2006)

Stat92E^85C9 has head | somatic clone phenotype, suppressible by wg[+]/wg^l-16

(Ekas et al., 2006)

Stat92E^85C9 has eye | somatic clone phenotype, suppressible by wg[+]/wg^l-16

(Ekas et al., 2006)

Enhancer of

Statement

Reference

Stat92E^85C9/Stat92E[+] is an enhancer of eye phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Stat92E^85C9/Stat92E[+] is an enhancer of wing phenotype of upd3^d232a

(Wang et al., 2014)

Stat92E^85C9/Stat92E[+] is an enhancer of haltere phenotype of upd3^d232a

(Wang et al., 2014)

NOT Enhancer of

Statement

Reference

Stat92E^85C9/Stat92E[+] is a non-enhancer of eye phenotype of upd3^x21b

(Wang et al., 2014)

Stat92E^85C9/Stat92E[+] is a non-enhancer of eye phenotype of upd3^d232a

(Wang et al., 2014)

Suppressor of

Statement

Reference

Stat92E^85C9/Stat92E[+] is a suppressor of eye | somatic clone | heat sensitive phenotype of Uba1^D6

(Lee et al., 2008)

NOT Suppressor of

Statement

Reference

Stat92E^85C9/Stat92E^85C9 is a non-suppressor | cell autonomous of autophagosome | somatic clone | cell non-autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³

(Katheder et al., 2017)

Stat92E^85C9/Stat92E^85C9 is a non-suppressor | cell autonomous of eye-antennal disc | somatic clone | cell non-autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib⁶⁷³

(Katheder et al., 2017)

Other

Statement

Reference

Stat92E^85C9/Stat92E[+], upd3^x21b has wing phenotype

(Wang et al., 2014)

Stat92E^85C9/Stat92E[+], upd3^x21b has haltere phenotype

(Wang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The cell non-autonomous increase in autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring tissue resulting from the presence of clones homozygous for scrib⁶⁷³ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU in third instar larval eye-antennal imaginal discs is not suppressed by Stat92E^85C9 homozygosity in the full organism apart from the clone cells.

(Katheder et al., 2017)

One copy of Stat92E^85C9 modestly but significantly enhances the reduction in eye size seen in upd3^d232a mutant flies, but the reduction in eye size is similar to that seen in Stat92E^85C9 mutants alone.

One copy of Stat92E^85C9 strongly enhances the outstretched wing and held down haltere phenotypes seen in upd3^d232a mutant flies.

Stat92E^85C9 does not significantly enhance the reduction in eye size seen in upd3^x21b mutant flies.

Stat92E^85C9 produces outstretched wing and held down haltere phenotypes in upd3^x21b mutant flies.

(Wang et al., 2014)

The overgrowth phenotype seen in Df(2R)P3C mutant eye discs is partially suppressed by Stat92E^85C9/+. The pupal lethality of Df(2R)P3C homozygotes is partially suppressed by Stat92E^85C9/+.

(Classen et al., 2009)

The eye overgrowth phenotype seen in Uba1^D6 mosaics raised at 29[o]C is dominantly suppressed by Stat92E^85C9.

(Lee et al., 2008)

Flies carrying Stat92E^85C9 Minute clones in a wg^l-16/+ background show a significantly increased rate of eclosion compared to those with a wild-type background. Further, eclosed wg^l-16/+; Stat92E^85C9 Minute flies show less severe phenotypes compared to eclosed Stat92E^85C9 Minute flies.

(Ekas et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Stat92E³⁹⁷

(Silver and Montell, 2001)

Stat92E^56D3

(Silver and Montell, 2001)

Stat92E^80A7

(Silver and Montell, 2001)

Stat92E⁰⁶³⁴⁶

(Silver and Montell, 2001)

Rescued by

Stat92E^85C9 is rescued by Stat92E^UASp.Tag:HA/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is rescued by Stat92E^{ΔN.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is rescued by Stat92E^{ΔC.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is rescued by Stat92E^{ΔNΔC.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is rescued by Stat92E^UASp.Tag:HA/Scer\GAL4^ey.PH

(Ekas et al., 2006)

Partially rescued by

Stat92E^85C9 is partially rescued by Stat92E^UASp.Tag:HA/Scer\GAL4^Tub.PU

(Ekas et al., 2010)

Stat92E^85C9 is partially rescued by Stat92E^UASp.Tag:HA/Scer\GAL4^Act.PU

(Ekas et al., 2010)

Stat92E^85C9 is partially rescued by Stat92E^{ΔN.UASp.Tag:HA}/Scer\GAL4^Tub.PU

(Ekas et al., 2010)

Stat92E^85C9 is partially rescued by Stat92E^{ΔC.UASp.Tag:HA}/Scer\GAL4^Tub.PU

(Ekas et al., 2010)

Stat92E^85C9 is partially rescued by Scer\GAL4^Tub.PU/Stat92E^{ΔNΔC.UASp.Tag:HA}

(Ekas et al., 2010)

Not rescued by

Stat92E^85C9 is not rescued by Stat92E^{R442P.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is not rescued by Stat92E^{R442K.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is not rescued by Stat92E^{R442A.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Stat92E^85C9 is not rescued by Stat92E^{Y711F.UASp.Tag:HA}/Scer\GAL4^ey.PH

(Ekas et al., 2010)

Comments

The mutant eye phenotype seen in mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E^85C9 is completely rescued by Stat92E^{Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{ΔN.Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{ΔC.Scer\UAS.P\T.T:Ivir\HA1} or Stat92E^{ΔNΔC.Scer\UAS.P\T.T:Ivir\HA1} expressed under the control of Scer\GAL4^ey.PH.

The mutant eye phenotype seen in mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E^85C9 is not rescued by Stat92E^{R442P.Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{R442K.Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{R442A.Scer\UAS.P\T.T:Ivir\HA1} or Stat92E^{Y711F.Scer\UAS.P\T.T:Ivir\HA1} expressed under the control of Scer\GAL4^ey.PH.

Expression of Stat92E^{Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{ΔN.Scer\UAS.P\T.T:Ivir\HA1}, Stat92E^{ΔC.Scer\UAS.P\T.T:Ivir\HA1} or Stat92E^{ΔNΔC.Scer\UAS.P\T.T:Ivir\HA1} under the control of Scer\GAL4^tub.PU significantly delays the lethal phase of Stat92E^85C9 homozygotes, such that most of the animals die as third instar larvae or early pupae.

Expression of Stat92E^{Scer\UAS.P\T.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU significantly delays the lethal phase of Stat92E^85C9 homozygotes, such that most of the animals die as late larvae.

(Ekas et al., 2010)

Stat92E^85C9 fails to complement Stat92E³⁹⁷, Stat92E^56D3 and Stat92E^80A7 with respect to lethality.

(Silver and Montell, 2001)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Stat92E^85C9

(Yuen et al., 2021, Worley et al., 2018, Clemente-Ruiz et al., 2016, Fregoso Lomas et al., 2016, Wang et al., 2014, Ekas et al., 2010, Flaherty et al., 2010, Ngo et al., 2010)

Stat92E^85c9

(Crucianelli et al., 2022, Spratford and Kumar, 2015)

stat92^85c9

(Lee et al., 2008)

stat92E^85C9

(Katheder et al., 2017, Hatini et al., 2013, Wu et al., 2010, Flaherty et al., 2009, Betz et al., 2008, Bach et al., 2007, Ekas et al., 2006)

stat92E^85c9

(Recasens-Alvarez et al., 2017)

stat92E^89C5

(Betz et al., 2008)

stat^85c9

(Leatherman and DiNardo, 2008)

Name Synonyms

Secondary FlyBase IDs

References (23)

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