FB2024_03 , released June 25, 2024
Allele: Dmel\Stat92EUASp.Tag:HA
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General Information
Symbol
Dmel\Stat92EUASp.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0211027
Feature type
allele
Associated gene
Dmel\Stat92E
Associated Insertion(s)
Carried in Construct
P{UASp-Stat92E.3HA}
Key Links
Transgenic product class
functionally_normal
(Ekas et al., 2010)
missense_variant
(Ekas et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
functionally_normal
(Ekas et al., 2010)
missense_variant
(Ekas et al., 2010)
Mutagen
in vitro construct
(Ekas et al., 2006)
Progenitor genotype
Carried in construct
P{UASp-Stat92E.3HA}
Cytology
Description

The P{UASp-Stat92E.3HA} transgene has a point mutation which results in an Ala substitution of Ser at position 8. This does not affect the function of the protein produced as it can rescue Stat92E loss of function phenotypes.

(Ekas et al., 2010)

UASp regulatory sequences drive expression of Stat92E, which is tagged with three copies of the Tag:HA epitope.

(Ekas et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Stat92E
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Stat92EScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4ey.PH does not result in eye overgrowth.

      Expression of Stat92EScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4Act5C.PI in clones does not result in melanotic tumours.

      (Ekas et al., 2010)

      Expression of Stat92EScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4ey.PH causes no visible phenotype.

      (Ekas et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Stat92EUASp.Tag:HA/Scer\GAL4ey.PH rescues Stat92E397

      (Ekas et al., 2010)

      Stat92EUASp.Tag:HA/Scer\GAL4ey.PH rescues Stat92E85C9

      (Ekas et al., 2010)

      Stat92EUASp.Tag:HA/Scer\GAL4ey.PH rescues Stat92E85C9

      (Ekas et al., 2006)
      Partially rescues

      Stat92EUASp.Tag:HA/Scer\GAL4Tub.PU partially rescues Stat92E85C9

      (Ekas et al., 2010)

      Stat92EUASp.Tag:HA/Scer\GAL4Act.PU partially rescues Stat92E85C9

      (Ekas et al., 2010)
      Comments

      The mutant eye phenotype seen in mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E85C9 is completely rescued by Stat92EScer\UAS.P\T.T:Ivir\HA1 expressed under the control of Scer\GAL4ey.PH.

      The mutant eye phenotype seen in mosaic animals in which the eye-antennal disc is almost completely homozygous for Stat92E397 is rescued by Stat92EScer\UAS.P\T.T:Ivir\HA1 expressed under the control of Scer\GAL4ey.PH.

      Expression of Stat92EScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4tub.PU significantly delays the lethal phase of Stat92E85C9 homozygotes, such that most of the animals die as third instar larvae or early pupae.

      Expression of Stat92EScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4Act.PU significantly delays the lethal phase of Stat92E85C9 homozygotes, such that most of the animals die as late larvae.

      (Ekas et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Stat92EScer\UAS.P\T.T:Ivir\HA1
      Stat92EUASp.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)