FlyBase Allele Report: Dmel\sc[UAS.cPa]

General Information

Symbol

Dmel\sc^UAS.cPa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Paras

FlyBase ID

FBal0056209

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

Carried in Construct

P{UAS-sc.P}

Also Known As

UAS-sc

Key Links

Transgenic product class

wild_type

(Parras et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parras et al., 1996)

Mutagen

in vitro construct

(Chu et al., 1998, Parras et al., 1996)

Progenitor genotype

Carried in construct

P{UAS-sc.P}

Cytology

Description

UAS regulatory sequences drive sc expression.

(Parras et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult midgut, with Scer\GAL4^{Delta-05151-G}

(Chen et al., 2018)

adult midgut | somatic clone, with Scer\GAL4^Act.PU

(Yin and Xi, 2018)

adult midgut epithelium, with Scer\GAL4^{Delta-05151-G}

(Chen et al., 2018)

chaeta | ectopic, with Scer\GAL4^pnr-MD237

(Giagtzoglou et al., 2003)

chaeta | ectopic & mesothoracic tergum, with Scer\GAL4^C-765

(Villa-Cuesta et al., 2003)

enteroendocrine cell | adult stage | somatic clone, with Scer\GAL4^Act.PU

(Yin and Xi, 2018)

intestinal stem cell | adult stage, with Scer\GAL4^{Delta-05151-G}

(Chen et al., 2018)

macrochaeta | ectopic, with Scer\GAL4^C-765

(Escudero et al., 2005)

macrochaeta | increased number, with Scer\GAL4^pnr-MD237

(Wildonger and Mann, 2005)

scutellar bristle | increased number, with Scer\GAL4^pnr-MD237, sc^A

(de Navascués and Modolell, 2010)

sensory mother cell | increased number, with Scer\GAL4^dpp.blk1

(Johnson et al., 2011)

wing disc, with Scer\GAL4^dpp.blk1

(Johnson et al., 2011)

wing sensillum | ectopic, with Scer\GAL4^C-765

(Villa-Cuesta et al., 2003)

Detailed Description

Statement

Reference

Clonal expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^Act.PU in the adult midgut results in a significant increase in the enteroendocrine cells within the clones, as compared to control clones.

(Yin and Xi, 2018)

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^tub.PU in clones in the wing disc induces the formation of sensory organ precursor cells in some cases.

(Zarifi et al., 2012)

The mis-expression of sc^Scer\UAS.cPa in the wing imaginal disc by means of Scer\GAL4^dpp.blk1 leads to the generation of supernumerary sensory organ precursors (SOPs) along the anterior-posterior boundary.

(Johnson et al., 2011)

Overexpression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 in a homozygous sc^A mutant background is a potent bristle inducer.

(de Navascués and Modolell, 2010)

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^C-765 results in extra macrochaetae on the notum.

(Escudero et al., 2005)

There are many extra macrochaetae present on the thoraces of flies expressing sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237.

(Wildonger and Mann, 2005)

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 results in ectopic chaetae.

(Giagtzoglou et al., 2003)

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^C-765 results in the formation of a few extra bristles on the notum and wing.

(Villa-Cuesta et al., 2003)

Expression of ac^Scer\UAS.cPa and sc^Scer\UAS.cPa under the control of Scer\GAL4^Kr.PM does not rescue neuroblast formation in vnd^D38 embryos.

(Chu et al., 1998)

Scer\GAL4^rho.PL mediated expression completely restores the development of a genuine MP2 neuroblast in In(1)y^3PLsc^8R embryos.

(Parras et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, sc^A, sc^UAS.cPa has visible phenotype, enhanceable by Chi^E

(de Navascués and Modolell, 2010)

Scer\GAL4^pnr-MD237, sc^A, sc^UAS.cPa has visible phenotype, enhanceable by tup^RNAi.UAS/Scer\GAL4^pnr-MD237

(de Navascués and Modolell, 2010)

Suppressed by

Statement

Reference

Scer\GAL4^C-765, sc^UAS.cPa has visible phenotype, suppressible | partially by Scer\GAL4^C-765/chn^RNAi.UAS

(Escudero et al., 2005)

NOT suppressed by

Statement

Reference

Scer\GAL4^Act.PU, sc^UAS.cPa has decreased cell number | somatic clone | adult stage phenotype, non-suppressible by sina^KK107603/Scer\GAL4^Act.PU

(Yin and Xi, 2018)

Enhancer of

Statement

Reference

sc^UAS.cPa/Scer\GAL4^sca-109-68 is an enhancer of visible | adult stage | dominant phenotype of lncRNA:SMRG^M

(Xu et al., 2019)

sc^UAS.cPa/Scer\GAL4^sca-109-68 is an enhancer of visible | adult stage | dominant phenotype of E(spl)mβ-HLH^12-11

(Xu et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, sc^A, sc^UAS.cPa has scutellar bristle | increased number phenotype, enhanceable by Chi^E

(de Navascués and Modolell, 2010)

Scer\GAL4^pnr-MD237, sc^A, sc^UAS.cPa has scutellar bristle | increased number phenotype, enhanceable by tup^RNAi.UAS/Scer\GAL4^pnr-MD237

(de Navascués and Modolell, 2010)

Suppressed by

Statement

Reference

Scer\GAL4^C-765, sc^UAS.cPa has macrochaeta | ectopic phenotype, suppressible | partially by Scer\GAL4^C-765/chn^RNAi.UAS

(Escudero et al., 2005)

Scer\GAL4^pnr-MD237, sc^UAS.cPa has macrochaeta | increased number phenotype, suppressible by nvy^UAS.cWa

(Wildonger and Mann, 2005)

Scer\GAL4^pnr-MD237, sc^UAS.cPa has chaeta | ectopic phenotype, suppressible | partially by E(spl)mδ-HLH^UAS.cdCa, Scer\GAL4^pnr-MD237

(Giagtzoglou et al., 2003)

Scer\GAL4^pnr-MD237, sc^UAS.cPa has chaeta | ectopic phenotype, suppressible by E(spl)m7-HLH^UAS.cdCa, Scer\GAL4^pnr-MD237

(Giagtzoglou et al., 2003)

Scer\GAL4^pnr-MD237, sc^UAS.cPa has chaeta | ectopic phenotype, suppressible by E(spl)mγ-HLH^KNEQ.UAS, Scer\GAL4^pnr-MD237

(Giagtzoglou et al., 2003)

Scer\GAL4^pnr-MD237, sc^UAS.cPa has chaeta | ectopic phenotype, suppressible by E(spl)mγ-HLH^UAS.cLa, Scer\GAL4^pnr-MD237

(Giagtzoglou et al., 2003)

Scer\GAL4^pnr-MD237, sc^UAS.cPa has chaeta | ectopic phenotype, suppressible by E(spl)m7-HLH^KNEQ.UAS, Scer\GAL4^pnr-MD237

(Giagtzoglou et al., 2003)

NOT suppressed by

Statement

Reference

Scer\GAL4^Act.PU, sc^UAS.cPa has enteroendocrine cell | somatic clone | adult stage phenotype, non-suppressible by sina^KK107603/Scer\GAL4^Act.PU

(Yin and Xi, 2018)

Scer\GAL4^Act.PU, sc^UAS.cPa has adult midgut | somatic clone phenotype, non-suppressible by sina^KK107603/Scer\GAL4^Act.PU

(Yin and Xi, 2018)

Enhancer of

Statement

Reference

sc^UAS.cPa/Scer\GAL4^sca-109-68 is an enhancer of scutellar bristle | increased number phenotype of lncRNA:SMRG^M

(Xu et al., 2019)

sc^UAS.cPa/Scer\GAL4^sca-109-68 is an enhancer of scutellar bristle | increased number phenotype of E(spl)mβ-HLH^12-11

(Xu et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Kr.PM/sc^UAS.cPa is a non-suppressor of medial ventral neurectoderm phenotype of vnd^D38

(Chu et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The increased number of enteroendocrine cells observed in adult midgut clones expressing sc^Scer\UAS.cPa under the control of Scer\GAL4^Act.PU is not suppressed by the co-expression of sina^KK107603.

(Yin and Xi, 2018)

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^tub.PU in clones in the wing disc in a Df(1)260-1 background does not induce the formation of sensory organ precursor cells.

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^sca-C253 is able to induce sensory organ precursor cells in the wing disc, which result in bristles in the adult notum, in a Df(1)sc10-1 background.

(Zarifi et al., 2012)

Roughly twice as many bristles are generated when sc^Scer\UAS.cPa is overexpressed under the control of Scer\GAL4^pnr-MD237 in a homozygous sc^A Chi^E double mutant background compared with that in a homozygous sc^A single mutant genetic background.

Roughly twice as many bristles are generated when both tup^{dsRNA.Scer\UAS} and sc^Scer\UAS.cPa are overexpressed under the control of Scer\GAL4^pnr-MD237 in a homozygous sc^A mutant background compared with that of sc^Scer\UAS.cPa overexpression alone.

(de Navascués and Modolell, 2010)

Co-expression of nvy^Scer\UAS.cWa with sc^Scer\UAS.cPa, both under the control of Scer\GAL4^pnr-MD237, results in the same phenotype caused by nvy^Scer\UAS.cWa single expression, in which dorsal thoracic macrochaetae are missing. The extra macrochaetae phenotype caused by sc^Scer\UAS.cPa single expression is completely suppressed.

(Wildonger and Mann, 2005)

Co-expression of HLHm7^{Scer\UAS.cdCa} and sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 results in adult flies with a bald stripe in the centre of the thorax (the formation of ectopic chaetae caused by expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 is suppressed in these flies). Co-expression of HLHmγ^Scer\UAS.cLa and sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 results in adult flies with a bald stripe in the centre of the thorax (the formation of ectopic chaetae caused by expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 is suppressed in these flies). Co-expression of HLHmγ^{KNEQ.Scer\UAS} and sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 results in adult flies with a bald stripe in the centre of the thorax (the formation of ectopic chaetae caused by expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 is suppressed in these flies). Co-expression of HLHm7^{KNEQ.Scer\UAS} and sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 results in adult flies with a bald stripe in the centre of the thorax (the formation of ectopic chaetae caused by expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 is suppressed in these flies). Co-expression of HLHmδ^{Scer\UAS.cdCa} partially suppresses the ectopic chaetae phenotype caused by expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237. Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^pnr-MD237 induces bristle formation in a Df(1)sc10-1/Y background.

(Giagtzoglou et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Expression of sc^Scer\UAS.cPa under the control of Scer\GAL4^klu-G410 results in the recovery of bristles on the notum in Df(1)sc10-1 flies.

(Kaspar et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26687

w^*; P{UAS-sc.P}39

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sc^Scer\UAS.cPa

sc^UAS.cPa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Paras

(Parras et al., 1996)

Secondary FlyBase IDs

References (22)

Report Sections

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