FlyBase Allele Report: Dmel\vnd[D38]

General Information

Symbol

Dmel\vnd^D38

Species

D. melanogaster

Name

FlyBase ID

FBal0094301

Feature type

allele

Associated gene

Dmel\vnd

Associated Insertion(s)

Carried in Construct

Also Known As

vnd^Δ38

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Chu et al., 1998)

Progenitor genotype

P{lacZ.ry⁺}rF124

(Chu et al., 1998)

Caused by aberration

Df(1)vnd^D38

Cytology

Description

Excision of the P{lacZ-un1}rF124 insertion resulting in a deletion that removes part of the 3' coding sequence of vnd.

(Chu et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Zhao and Skeath, 2002)

Phenotype Manifest In

dMP2 neuron

(Chu et al., 1998)

larval DA1 motor neuron

(Chu et al., 1998)

larval RP2 motor neuron

(Chu et al., 1998)

medial ventral neurectoderm

(Chu et al., 1998)

neuroblast NB4-1

(Zhao and Skeath, 2002)

neuroblast NB6-1

(Zhao and Skeath, 2002)

pCC neuron

(Chu et al., 1998)

vMP2 neuron

(Chu et al., 1998)

Detailed Description

Statement

Reference

NB 6-1 is not formed in 64.5% of cases and NB 4-1 is not formed in 60.7% of cases in mutant embryos.

(Zhao and Skeath, 2002)

The number of ventral column neuroblasts is greatly reduced in homozygous embryos, while the intermediate and dorsal columns form normally. The aCC/pCC and dMP2/vMP2 neurons and GMC 7-1a are almost invariably absent in these embryos. The RP2 neuron is absent in 13% of embryos.

(Chu et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

D⁸⁷, vnd^D38 has abnormal neuroanatomy phenotype

(Zhao and Skeath, 2002)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

vnd^D38 has medial ventral neurectoderm phenotype, non-suppressible by Scer\GAL4^Kr.PM/ac^UAS.cPa

(Chu et al., 1998)

vnd^D38 has medial ventral neurectoderm phenotype, non-suppressible by Scer\GAL4^rho.PL/ac^UAS.cPa

(Chu et al., 1998)

vnd^D38 has medial ventral neurectoderm phenotype, non-suppressible by Scer\GAL4^Kr.PM/l(1)sc^UAS.cPa

(Chu et al., 1998)

vnd^D38 has medial ventral neurectoderm phenotype, non-suppressible by Scer\GAL4^Kr.PM/sc^UAS.cPa

(Chu et al., 1998)

Other

Statement

Reference

SoxN^C2139, vnd^D38 has neuroblast NB5-2 phenotype

(Buescher et al., 2002)

SoxN^C2139, vnd^D38 has neuroblast NB1-1 phenotype

(Buescher et al., 2002)

SoxN^C2139, vnd[+]/vnd^D38 has neuroblast NB7-1 phenotype

(Buescher et al., 2002)

SoxN^C2139, vnd[+]/vnd^D38 has neuroblast NB5-2 phenotype

(Buescher et al., 2002)

SoxN^C2139, vnd[+]/vnd^D38 has neuroblast NB1-1 phenotype

(Buescher et al., 2002)

SoxN^C2139, vnd^D38 has neuroblast NB7-1 phenotype

(Buescher et al., 2002)

D⁸⁷, vnd^D38 has neuroblast NB6-1 phenotype

(Zhao and Skeath, 2002)

D⁸⁷, vnd^D38 has neuroblast NB4-1 phenotype

(Zhao and Skeath, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

vnd^D38/+ ; SoxN^C2139 embryos show an increased loss of ventral S1 neuroblasts compared to SoxN^C2139 single mutants; NB5-2 is lost in 12% of hemisegments, NB7-1 shows 17% loss and NB1-1 shows 18% loss.

(Buescher et al., 2002)

vnd^D38 ; D⁸⁷ double mutant embryos lack 90.9% of NB 6-1 and 89.2% of NB 4-1.

(Zhao and Skeath, 2002)

Expression of ac^Scer\UAS.cPa and sc^Scer\UAS.cPa under the control of Scer\GAL4^Kr.PM does not rescue neuroblast formation in vnd^D38 embryos. Expression of l(1)sc^Scer\UAS.cPa under the control of Scer\GAL4^Kr.PM does not rescue neuroblast formation in vnd^D38 embryos.

(Chu et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

vnd⁵

(Chu et al., 1998)

Partially rescued by

vnd^D38 is partially rescued by Scer\GAL4^Kr.PM/vnd^UAS.cCa

(Chu et al., 1998)

vnd^D38 is partially rescued by Scer\GAL4^rho.PL/vnd^UAS.cCa

(Chu et al., 1998)

Not rescued by

vnd^D38 is not rescued by vnd^UAS.cCa/Scer\GAL4^sca-537.4

(Chu et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

vnd^D38

(Herrero et al., 2014)

vnd^Δ38

(Buescher et al., 2002, Zhao and Skeath, 2002, Ashraf and Ip, 2001)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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