FB2024_03 , released June 25, 2024
Allele: Dmel\Ras85DN17.UAS
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General Information
Symbol
Dmel\Ras85DN17.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0048924
Feature type
allele
Associated gene
Dmel\Ras85D
Associated Insertion(s)
Carried in Construct
P{UAS-Ras85D.N17}
Also Known As
UAS-rasN17, UAS-RasDN, UAS-RasN17, UAS-Ras85D.N17, UAS-DrasN17, UAS-Ras1N17, UAS-Dras1N17, UAS-Ras85DN17, RasN17, rasdn
Key Links
Transgenic product class
dominant_negative_variant
(Lee et al., 1996)
missense_variant
(Lee et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Lee et al., 1996)
missense_variant
(Lee et al., 1996)
Mutagen
in vitro construct
(Kerber et al., 1998, Lee et al., 1996)
Progenitor genotype
Carried in construct
P{UAS-Ras85D.N17}
Cytology
Description

A dominant-negative form of Ras85D is expressed under the control of UASt regulatory sequences.

(Lee et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ras85D
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Noonan syndrome 3
      CEA
      (Cattaneo et al., 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  brain glioma
      modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Read et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal developmental rate | second instar larval stage, with Scer\GAL4amn-c651

      (Caldwell et al., 2005)

      abnormal neuroanatomy, with Scer\GAL4futsch-C380

      (Koh et al., 2002)

      abnormal neuroanatomy | embryonic stage, with Scer\GAL4repo

      (Sepp and Auld, 2003)

      abnormal size | adult stage, with Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      decreased cell number | adult stage, with Scer\GAL4NP5130

      (Bond and Foley, 2012)

      decreased cell number | larval stage | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      decreased cell size | adult stage, with Scer\GAL4Su(H).GBE

      (Rojas Villa et al., 2019)

      decreased cell size | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      decreased occurrence of cell division | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      increased body size | adult stage, with Scer\GAL4amn-c651

      (Caldwell et al., 2005)

      increased body size | pupal stage, with Scer\GAL4amn-c651

      (Caldwell et al., 2005)

      increased body size | pupal stage, with Scer\GAL4amn-X8

      (Caldwell et al., 2005)

      increased cell death | cell autonomous | larval stage | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      increased cell death | embryonic stage, with Scer\GAL4en-e16E

      (Parker, 2006)

      increased cell size | embryonic stage, with Scer\GAL4en-e16E

      (Parker, 2006)

      lethal, with Scer\GAL4elav.PLu

      (Fritz and VanBerkum, 2002)

      long lived | RU486 conditional, with Scer\GAL4da.Switch.PT

      (Slack et al., 2015)

      long lived | RU486 conditional, with Scer\GAL4Switch1.106

      (Slack et al., 2015)

      visible, with Scer\GAL4bi.PU

      (Rendina et al., 2010)

      visible, with Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      visible, with Scer\GAL4dpp.blk1

      (Ishimaru et al., 1999)

      visible, with Scer\GAL4ey.PH

      (Fritz and VanBerkum, 2002)

      visible, with Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      visible | adult stage, with Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      visible | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)
      Phenotype Manifest In

      adult gut, with Scer\GAL4NP0001

      (Buchon et al., 2010)

      adult gut, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B

      (Buchon et al., 2010)

      adult gut, with Scer\GAL4Su(H).GBE

      (Rojas Villa et al., 2019)

      anterior crossvein, with Scer\GAL4dpp.blk1

      (Ishimaru et al., 1999)

      border follicle cell, with Scer\GAL4c306

      (Lee et al., 1996)

      border follicle cell, with Scer\GAL4slbo.2.6

      (Duchek and Rorth, 2001)

      bouton | increased number, with Scer\GAL4futsch-C380

      (Koh et al., 2002)

      dMP2 neuron, with Scer\GAL4elav.PLu

      (Fritz and VanBerkum, 2002)

      embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB

      (Harden et al., 1999)

      embryonic/larval ganglionic tracheal branch, with Scer\GAL4bs-23.26

      (Gallio et al., 2004)

      embryonic/larval hemocyte, with Scer\GAL4srp.Hemo

      (Bruckner et al., 2004)

      embryonic longitudinal glial cell, with Scer\GAL4S007708-Jan136

      (Hidalgo et al., 2001)

      embryonic segment, with Scer\GAL4en-e16E

      (Parker, 2006)

      enteroblast | adult stage, with Scer\GAL4Su(H).GBE

      (Rojas Villa et al., 2019)

      enteroblast of posterior adult midgut epithelium, with Scer\GAL4NP5130

      (Bond and Foley, 2012)

      eye, with Scer\GAL4ey.PH

      (Fritz and VanBerkum, 2002)

      eye, with Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      eye disc morphogenetic furrow, with Scer\GAL4dpp.blk1

      (Kumar and Moses, 2001)

      fascicle | embryonic stage, with Scer\GAL4repo

      (Sepp and Auld, 2003)

      fusion competent cell, with Scer\GAL4twi.PB

      (Beckett and Baylies, 2006)

      germline stem cell | increased number, with Scer\GAL4C587

      (Gilboa and Lehmann, 2006)

      glial cell, with Scer\GAL4repo, Scer\GAL80ts.αTub84B

      (Lu et al., 2014)

      glial cell & antennal disc, with Scer\GAL4hs.PB

      (Sen et al., 2004)

      imaginal disc | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      intestinal stem cell | adult stage, with Scer\GAL4NP5130

      (Bond and Foley, 2012)

      larval optic lobe & glial cell | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PP

      (Dearborn and Kunes, 2004)

      medulla cortex & glial cell | somatic clone | cell non-autonomous, with Scer\GAL4αTub84B.PP

      (Dearborn and Kunes, 2004)

      mesothoracic tergum, with Scer\GAL4Ubx-lac1-Gal4

      (Pallavi and Shashidhara, 2003)

      mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      motor neuron | embryonic stage, with Scer\GAL4repo

      (Sepp and Auld, 2003)

      pCC neuron, with Scer\GAL4elav.PLu

      (Fritz and VanBerkum, 2002)

      photoreceptor cell & axon & eye disc, with Scer\GAL4bi-omb-Gal4

      (Rangarajan et al., 1999)

      PNS glial cell | embryonic stage, with Scer\GAL4repo

      (Sepp and Auld, 2003)

      presumptive embryonic/larval peripheral nervous system, with Scer\GAL4repo

      (Sepp and Auld, 2003)

      sensory neuron & axon & embryo, with Scer\GAL4repo

      (Sepp and Auld, 2003)

      subretinal glial cell & eye disc, with Scer\GAL4bi-omb-Gal4

      (Rangarajan et al., 1999)

      subretinal glial cell & larval optic stalk, with Scer\GAL4bi-omb-Gal4

      (Rangarajan et al., 1999)

      tracheal branch primordium, with Scer\GAL4btl.PS

      (Cela and Llimargas, 2006)

      vesicle, with Scer\GAL4repo, Scer\GAL80ts.αTub84B

      (Lu et al., 2014)

      vMP2 neuron, with Scer\GAL4elav.PLu

      (Fritz and VanBerkum, 2002)

      wing, with Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      wing, with Scer\GAL4Ubx-lac1-Gal4

      (Pallavi and Shashidhara, 2003)

      wing disc, with Scer\GAL4ap-md544

      (Pallavi and Shashidhara, 2003)

      wing disc, with Scer\GAL4Gug-AGiR

      (Pallavi and Shashidhara, 2003)

      wing disc, with Scer\GAL4tsh-md621

      (Pallavi and Shashidhara, 2003)

      wing disc, with Scer\GAL4Ubx-lac1-Gal4

      (Pallavi and Shashidhara, 2003)

      wing vein, with Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020, Friedman et al., 2011)

      wing vein, with Scer\GAL4MD-638

      (Terriente-Félix and de Celis, 2009)

      wing vein | somatic clone, with Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      wing vein L4, with Scer\GAL4bi.PU

      (Rendina et al., 2010)
      Detailed Description
      Statement
      Reference

      Expressing Ras85DN17.UAS under the control of Scer\GAL4Bx-MS1096 results in a reduced wing size and loss of vein material.

      (Kushnir et al., 2020)

      Expression of Ras85DN17.UAS under the control of Scer\GAL4Su(H).GBE (in combination with tub-Gal80[ts] to restrict expression to the adult stage) leads to a decrease in the cell size of enteroblasts in adult guts when compared to controls.

      (Rojas Villa et al., 2019)

      Expression of Ras85DN17.Scer\UAS specifically in adult glia (under the control of Scer\GAL4repo and Scer\GAL80ts.αTub84B) generates a mild glial engulfment phenotype, resulting in a slight delay in phagocytosis of axonal debris after axotomy.

      (Lu et al., 2014)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B has a mild reducing effect on intestinal stem cells/epithelial enteroblasts cell numbers.

      (Bond and Foley, 2012)

      Subperineurial expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4Gli-rL82 in a wild-type genetic background has only a minor effect on larval peripheral nerves.

      (Dahlgaard et al., 2012)

      Increased gut length is observed in flies expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4Myo31DF-NP0001.

      Guts of flies expressing Ras85DN17.Scer\UAS in enterocytes under the control of Scer\GAL4Myo31DF-NP0001 and Scer\GAL80ts.αTub84B shrink less upon infection with Erwinia carotovora carotovora 15 (Ecc15). After a recovery phase of 2 or 8 days, the guts are 25% longer than their wild-type counterparts.

      (Buchon et al., 2010)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4bi.PU results in the loss of the central part of wing vein L4.

      (Rendina et al., 2010)

      Expression of Ras85DN17.Scer\UAS in the larvae under the control of Scer\GAL4Act5C.Switch.PR does not result in lethality. Both male and female life-span not reduced significantly when Ras85DV12.Scer\UAS is expressed in adult flies.

      (Shen et al., 2009)

      Expression of Ras85DN17.Scer\UAS in the wing blade using Scer\GAL4MD-638 results in loss of sections of wing vein.

      (Terriente-Félix and de Celis, 2009)

      The number of fusion competent myoblasts is increased in stage 11 embryos that express Ras85DV12.Scer\UAS under the control of Scer\GAL4twi.PB.

      (Beckett and Baylies, 2006)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4btl.PS results tracheal branching defects in embryos.

      (Cela and Llimargas, 2006)

      There is a large increase in primordial germ cell numbers when the dominant negative Ras85DN17.Scer\UAS is expressed in somatic gonadal cells by Scer\GAL4C587.

      (Gilboa and Lehmann, 2006)

      Expression of Ras85DN17.Scer\UAS, under the control of Scer\GAL4en-e16E, in the posterior compartment cells of embryos results in apoptosis of these cells, beginning at stage 12. The increased apoptosis occurs mainly at the front of the posterior compartment. Overall compartment size is reduced. Surviving cells are larger than normal.

      (Parker, 2006)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4amn-c651, results in pupae and adults that are larger than wild-type controls. These flies also undergo delayed pupariation about 48 hr after wild-type controls, which is mostly due to a prolonged second-instar stage. Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4amn-X8 causes an increase in pupal length. Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4amn-c651 has no effect on prothoracic gland cell size.

      (Caldwell et al., 2005)

      Hemocytes are mildly enlarged in about one third of Ras85DN17.Scer\UAS; Scer\GAL4srp.Hemo embryos.

      (Bruckner et al., 2004)

      Somatic clones of Ras85DN17.Scer\UAS; Scer\GAL4αTub84B.PP neurons in the posterior of the optic lobe result in failure of scaffold axons to extend toward glial destinations. When the scaffold axons are absent, glia stall prior to migrating into the neuropile regions. The number of apoptotic cells is increased in the cortical areas next to the resulting glia-deficient regions.

      (Dearborn and Kunes, 2004)

      Migration of ganglionic tracheal branches is abberant in Ras85DN17.Scer\UAS; Scer\GAL4bs-23.26 embryos. Migration of around half of these branches stalls outside the ventral nerve cord. A smaller proportion are grossly misrouted (8%) or cross the midline (4%).

      (Gallio et al., 2004)

      Flies expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4GMR.PU have reduced and roughened eyes.

      (Raymond et al., 2004)

      When Ras85DN17.Scer\UAS is driven by Scer\GAL4hs.PB and heatshocked between 14 and 15 hours after puparium formation, a severe reduction is seen in numbers of antennal glia.

      (Sen et al., 2004)

      Ras85DN17.Scer\UAS; Scer\GAL4prd.RG1 embryos do not have obvious cuticle phenotypes.

      (Urban et al., 2004)

      Ras85DN17.Scer\UAS with Scer\GAL4pnr-MD237 or Scer\GAL4426 does not affect wing disc development. Ras85DN17.Scer\UAS with Scer\GAL4ap-md544 or Scer\GAL4tsh-md621 causes severe reduction in notum tissue in the 3rd instar wing disc; however, no transformation of notum to wing fate is observed in these discs. Ras85DN17.Scer\UAS with Scer\GAL4Gug-AGiR causes reduction in notum tissue in the 3rd instar wing disc. Ras85DN17.Scer\UAS; Scer\GAL4Ubx-lac1-Gal4 adults exhibit wing duplication in the posterior compartment and partial loss of notum and/or hinge. Occasionally pharate adults die within the pupal case, with severe loss of notum tissue. In larvae of this genotype, the wing discs show altered morphology, particularly overgrowth in the posterior hinge and mesonotum. Marker analysis indicates formation a new wing pouch complete with the DV boundary, and that pattern duplication is associated with loss of notum, confirming notum/hinge-to-wing transformations. Ras85DN17.Scer\UAS; Scer\GAL4ap-md544 third instar wing discs show a severe reduction in the notum size.

      (Pallavi and Shashidhara, 2003)

      Expression of Ras85DN17.Scer\UAS in embryonic glia, under the control of Scer\GAL4repo, causes PNS patterning defects in hemisegments. Embryos show incomplete peripheral glial ensheathment of nerves and stalled glia that are able to extend cytoplasmic processes, although to a lesser extent than in wild type. In hemisegments that are moderately affected, sensory axons can be misdirected and nerves in the CNS-PNS transition zone show incorrect fasciculation-bundling. In severely-affected hemisegments, there is a loss of sensory neurons and those remaining have misplaced cell bodies and misdirected sensory axons. Additionally, motor neuron patterning is disrupted.

      (Sepp and Auld, 2003)

      Hemocytes in mutant embryos (Ras85DN17.Scer\UAS driven by Scer\GAL4gcm.PP) fail to enter the tail.

      (Cho et al., 2002)

      When Ras85DN17.Scer\UAS is driven by Scer\GAL4ftz.ng, no midline crossovers are seen in the pCC/MP2 pathway axons. When Ras85DN17.Scer\UAS is driven by Scer\GAL4ftz.ng, only 2% of embryos exhibit midline crossovers are seen in the pCC/MP2 pathway axons.

      (Fritz and VanBerkum, 2002)

      Expression of Ras85DN17.Scer\UAS driven by Scer\GAL4332.3 does not affect either the dorsal cuticle or amnioserosa morphology.

      (Harden et al., 2002)

      Expression of Ras85DN17.Scer\UAS, under the control of Scer\GAL4C380 increases the number of type I synaptic boutons compared to wild-type controls. This increase is indistinguishable from the increase in bouton number observed in flies where Ras85DScer\UAS.cKa expression is driven by Scer\GAL4C380.

      (Koh et al., 2002)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4slbo.2.6 moderately affects posterior and dorsal border cell migration.

      (Duchek and Rorth, 2001)

      Ras85DN17.Scer\UAS; P{sgcm-GAL4}151 embryos exhibit a dramatic increase in apoptosis of longitudinal (interface) glial cells.

      (Hidalgo et al., 2001)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4dpp.blk1 inhibits furrow reincarnation along the lateral margins, but not furrow birth at the posterior of the eye disc.

      (Kumar and Moses, 2001)

      Imaginal disc cells expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4Act5C.PP are smaller than wild-type cells. The cells have longer apparent doubling times. The cells mix well with neighbouring wild-type cells. Pyknotic nuclei, indicating cell autonomous cell death, are seen. The proportion of cells in G1 is increased and the proportion of cells in S phase is decreased. Clones expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4Act5C.PP fails to make veins in adult wings.

      (Prober and Edgar, 2000)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL4hs.PB (using heat shock) results in many first instar larvae with mild puckering of the dorsal cuticle.

      (Harden et al., 1999)

      The anterior crossvein is missing in flies expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4dpp.blk1.

      (Ishimaru et al., 1999)

      Expression of Ras85DN17.Scer\UAS under the control of Scer\GAL448Y in the developing midgut has no effect on the migration of the endodermal midgut cells.

      (Martin-Bermudo et al., 1999)

      The number of glial cells in the optic stalk is reduced and they fail to migrate into the eye disc in approximately 10% of eye discs expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4bi-omb-Gal4. In these cases the photoreceptor cells are able to grow axons and these axons orient their growth towards the posterior of the eye disc as in wild type. However, the axons then remain stuck in the eye disc and are unable to exit into the optic stalk. In 40% of cases, eye discs expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4bi-omb-Gal4 contain a small number of glial cells (3 to 20). These glial cells are found very close to the optic stalk at the very posterior end of the eye disc where they remain in a cluster. The cell bodies of the glial cells are small and do not extend much anteriorly. Axons are able to exit into the optic stalk normally in these eye discs.

      (Rangarajan et al., 1999)

      Scer\GAL4sli.PS-mediated expression in wild type embryos does not result in an abnormal CNS phenotype. Scer\GAL4sim.PS-mediated expression in Ras85D deficient embryos causes slight fusion of commissures.

      (Scholz et al., 1997, Scholz et al., 1997)

      The presence of Scer\GAL4c306 causes a mild delay in the migration of border cells in egg chambers. Border cell phenotype is enhanced in Scer\GAL4c306; P{UAS-Ras85D.N17}; Ras85DΔ17b/Ras85D+ flies.

      (Lee et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by C3GUAS.Tag:MYC, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by pblEP3415, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by poeEP349, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by poeEP737, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by P{EP}EP2233, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by numbEP2455, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by RhoGEF64CEP3322, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by DlatEP816, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      Suppressed by
      Statement
      Reference

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has abnormal size | adult stage phenotype, suppressible by rlD334N.UAS.cKa, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has abnormal size | adult stage phenotype, suppressible by rlR80S.D334N.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has abnormal size | adult stage phenotype, suppressible by rlR80S.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has visible | adult stage phenotype, suppressible by rlR80S.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has visible | adult stage phenotype, suppressible by rlD334N.UAS.cKa, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has visible | adult stage phenotype, suppressible by rlR80S.D334N.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Su(H).GBE has decreased cell size | adult stage phenotype, suppressible by zfh2EAB, Scer\GAL4Su(H).GBE

      (Rojas Villa et al., 2019)

      Ras85DN17.UAS, Scer\GAL4Switch1.106 has long lived | RU486 conditional phenotype, suppressible by aopHMS01256, Scer\GAL4Switch1.106

      (Slack et al., 2015)

      Ras85DN17.UAS has visible phenotype, suppressible by Spn42DcHM04068/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has visible phenotype, suppressible by dcoUAS.Tag:HA/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has visible phenotype, suppressible by fzyHM04081/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has visible phenotype, suppressible by CoRestHM04053/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has visible phenotype, suppressible by Vps4HM04061/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has visible phenotype, suppressible by Scer\GAL4Bx-MS1096/uriHM04028

      (Friedman et al., 2011)

      Ras85DN17.UAS, Scer\GAL4Act5C.PP has increased cell death | somatic clone | cell autonomous | larval stage phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      Ras85DN17.UAS, Scer\GAL4Act5C.PP has decreased occurrence of cell division | somatic clone | cell autonomous | larval stage phenotype, suppressible | partially by BacA\p35UAS.cHa, Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      Ras85DN17.UAS, Scer\GAL4Act5C.PP has decreased occurrence of cell division | somatic clone | cell autonomous | larval stage phenotype, suppressible by MycUAS.cZa, Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)
      NOT suppressed by
      Statement
      Reference

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has abnormal size | adult stage phenotype, non-suppressible by rlWT.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has visible | adult stage phenotype, non-suppressible by rlWT.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by C3GUAS.Tag:MYC, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by pblEP3415, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by RhoGEF64CEP3322, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by poeEP349, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by poeEP737, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by DlatEP816, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by P{EP}EP2233, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by numbEP2455, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by C3GUAS.Tag:MYC, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by pblEP3415, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by poeEP349, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by poeEP737, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by P{EP}EP2233, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by numbEP2455, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by RhoGEF64CEP3322, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by DlatEP816, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      Suppressed by
      Statement
      Reference

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing phenotype, suppressible by rlR80S.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing vein phenotype, suppressible by rlR80S.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing phenotype, suppressible by rlR80S.D334N.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing phenotype, suppressible by rlD334N.UAS.cKa, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing vein phenotype, suppressible by rlR80S.D334N.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing vein phenotype, suppressible by rlD334N.UAS.cKa, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Su(H).GBE has enteroblast | adult stage phenotype, suppressible by zfh2EAB, Scer\GAL4Su(H).GBE

      (Rojas Villa et al., 2019)

      Ras85DN17.UAS, Scer\GAL4Su(H).GBE has adult gut phenotype, suppressible by zfh2EAB, Scer\GAL4Su(H).GBE

      (Rojas Villa et al., 2019)

      Ras85DN17.UAS has wing vein phenotype, suppressible by Spn42DcHM04068/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has wing vein phenotype, suppressible by dcoUAS.Tag:HA/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has wing vein phenotype, suppressible by fzyHM04081/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has wing vein phenotype, suppressible by CoRestHM04053/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has wing vein phenotype, suppressible by Vps4HM04061/Scer\GAL4Bx-MS1096

      (Friedman et al., 2011)

      Ras85DN17.UAS has wing vein phenotype, suppressible by Scer\GAL4Bx-MS1096/uriHM04028

      (Friedman et al., 2011)

      Ras85DN17.UAS, Scer\GAL4ap-md544 has wing disc phenotype, suppressible | partially by BacA\p35UAS.cHa, Scer\GAL4ap-md544

      (Pallavi and Shashidhara, 2003)

      Ras85DN17.UAS, Scer\GAL4Act5C.PP has imaginal disc | somatic clone phenotype, suppressible | partially | somatic clone by BacA\p35UAS.cHa, Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)

      Ras85DN17.UAS, Scer\GAL4Act5C.PP has mitotic cell cycle | somatic clone phenotype, suppressible by MycUAS.cZa, Scer\GAL4Act5C.PP

      (Prober and Edgar, 2000)
      NOT suppressed by
      Statement
      Reference

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing phenotype, non-suppressible by rlWT.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4Bx-MS1096 has wing vein phenotype, non-suppressible by rlWT.UAS, Scer\GAL4Bx-MS1096

      (Kushnir et al., 2020)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by MESR4EP386, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Akap200EP2072, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by kisEP563, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by domEP2371, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Dp1EP2422, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by poeEP349, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by poeEP737, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}faxEP807, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by cdiEP3319, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Traf6EP325, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}wunEP652, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by DlatEP816, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by C3GUAS.Tag:MYC, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by rho-6EP2023, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by CG6701EP2054, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}EP2233, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by numbEP2455, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by cpoEP3395, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Gtpbp2EP3503, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by cindrEP3700, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by pblEP3415, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by RhoGEF64CEP3035, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by RhoGEF64CEP3322, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by hppyEP2445, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by SNF4AγEP648, Scer\GAL4GMR.PU

      (Raymond et al., 2004)

      Ras85DN17.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by P{EP}EP2491, Scer\GAL4GMR.PU

      (Raymond et al., 2004)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing defects induced by the expression of Ras85DN17.UAS under the control of Scer\GAL4Bx-MS1096 (smaller wing and loss of L3-5 vein material are: fully suppressed by the co-expression of either rlD334N.UAS.cKa or rlR80S.D334N.UAS, even leading to extra vein material (more severe in the latter, with darker pigmentation); partially suppressed by the co-expression of rlR80S.UAS (complete suppression in L3, partial suppression in L4 or L5); not suppressed by the co-expression of rlWT.UAS.

      (Kushnir et al., 2020)

      Co-expression of Ras85DN17.Scer\UAS and PvrCA.Scer\UAS under the control of Scer\GAL4esg-NP5130 and Scer\GAL80ts.αTub84B significantly abrogates the PvrCA.Scer\UAS dysplastic phenotype, indicating that Ras85D is a downstream signaling component in the Pvr-dependent regulation of intestinal homeostasis.

      (Bond and Foley, 2012)

      Expression of Ras85DN17.Scer\UAS in motor neurons under the control of Scer\GAL4unspecified suppresses the increased synaptic growth and transmitter release observed at the neuromuscular junction in comt6 Ca-P60AKum170 larvae.

      (Freeman et al., 2010)

      Co-expression of Bap170C1.Scer\UAS enhances the loss of wing vein L4 that is seen in flies expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4bi.PU, such that there is a loss of the entire L4 vein distal to the posterior crossvein. The distal end of wing vein L3 is missing in these flies and a reduction in wing surface area and occasional notching of the wing margin is also seen.

      (Rendina et al., 2010)

      Expression of Ras85DN17.Scer\UAS moderately suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.

      (Read et al., 2009)

      The loss of wing vein by overexpression of Ras85DN17.Scer\UAS under the control of Scer\GAL4MD-638 is enhanced by osa308/+.

      (Terriente-Félix and de Celis, 2009)

      Denticle belt fusions in the cuticles of rho7M43; ru1 double homozygous embryos are enhanced by Ras85DN17.Scer\UAS; Scer\GAL4prd.RG1.

      (Urban et al., 2004)

      The reduction in notum size seen in the wing discs of Ras85DN17.Scer\UAS; Scer\GAL4ap-md544 third instar larvae is partially suppressed by BacA\p35Scer\UAS.cHa.

      (Pallavi and Shashidhara, 2003)

      Co-expressing BacA\p35Scer\UAS.cHa with Ras85DN17.Scer\UAS under the control of Scer\GAL4Act5C.PP completely suppresses the Ras85DN17.Scer\UAS cell death phenotype and increases the number of cells per clone. The doubling time defect is only partially rescued. 40 hours after induction, clones in imaginal discs co-expressing Ras85DN17.Scer\UAS and BacA\p35Scer\UAS.cHa under the control of Scer\GAL4Act5C.PP are 23% smaller than clones expressing BacA\p35Scer\UAS.cHa alone under the control of Scer\GAL4Act5C.PP. Clones expressing both dmScer\UAS.cZa and Ras85DN17.Scer\UAS under the control of Scer\GAL4Act5C.PP in clones in the imaginal discs have a similar cell size and cell cycle profiles as those of cells expressing dmScer\UAS.cZa alone under the control of Scer\GAL4Act5C.PP. The elongated doubling time of cells expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4Act5C.PP is partially rescued by co-expression of dmScer\UAS.cZa.

      (Prober and Edgar, 2000)
      Xenogenetic Interactions
      Statement
      Reference

      The additional co-expression of Ras85DN17.Scer\UAS does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4GMR.PU.

      (Padash Barmchi et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      Reported As
      Symbol Synonym
      Dras1N17
      (Kerber et al., 1998)
      Ras1N17
      (Boettner et al., 2003)
      Ras1N17
      (Koh et al., 2002)
      Ras85DN17.Scer\UAS
      Ras85DN17.UAS
      (Oishi et al., 2006)
      RasDN
      (Helman et al., 2011)
      RasN17
      (Caldwell et al., 2005)
      rasdn
      (Parker, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (70)