FlyBase Allele Report: Dmel\cdi[EP3319]

General Information

Symbol

Dmel\cdi^EP3319

Species

D. melanogaster

Name

FlyBase ID

FBal0123024

Feature type

allele

Associated gene

Dmel\cdi

Associated Insertion(s)

P{EP}cdi^EP3319

Carried in Construct

Also Known As

EP(3)3319

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kraut et al., 2001, Kraut et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{EP}cdi^EP3319

Cytology

Description

The orientation of the P{EP} element is the same as the direction of cdi transcription.

(Shulman and Feany, 2003)

The P{EP} element is inserted within the 5' UTR.

(Kraut et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:19,094,242..19,094,242 [-]

(Chen et al., 2005, Raymond et al., 2004, Shulman and Feany, 2003, Fauvarque et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001, Kraut et al., 2001)

Detailed Description

Statement

Reference

Mutant larvae expressing cdi^EP3319 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

In the ventral muscle region of mutant larvae expressing cdi^EP3319 under the control of Scer\GAL4^elav-C155 ISN pathfinding defects can be seen. An identified branch is seen to leave the ISN and travel up to the region normally innervated by ISBNb. Other abnormal branches from ISNb are also observed.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhancer of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of RacGAP84C^GAP.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

NOT Suppressor of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

cdi^EP3319, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhancer of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

cdi^EP3319, Scer\GAL4^32B is a suppressor of wing phenotype of Pax^UAS.cCa, Scer\GAL4^32B

(Chen et al., 2005)

cdi^EP3319, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of RacGAP84C^GAP.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

NOT Suppressor of

Statement

Reference

cdi^EP3319, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

cdi^EP3319, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of cdi^EP3319 in flies expressing Pax^Scer\UAS.cCa under the control of Scer\GAL4^32B suppresses the blistered-wing phenotype.

(Chen et al., 2005)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by cdi^EP3319.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Precise excision of the P{EP} element reverts the modifying effect of cdi^EP3319 on the rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Shulman and Feany, 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cdi^EP3319

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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