FlyBase Allele Report: Dmel\Su(var)3-9[1]

General Information

Symbol

Dmel\Su(var)3-9¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016557

Feature type

allele

Associated gene

Dmel\Su(var)3-9

Associated Insertion(s)

Carried in Construct

Also Known As

Su(var)3-9⁰¹, 3-9¹

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Zhang et al., 2006, Ebert et al., 2004)

Mutagen

ethyl methanesulfonate

(Reuter et al., 1986)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C5036T.

(Romanov et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,261,700..15,261,700 [-]

Nucleotide change:

C15261700T

Reported nucleotide change:

C5036T

Amino acid change:

R147term | Su(var)3-9-PA

Reported amino acid change:

??term

Comment:

A C5036T substitution relative to GB:AJ290956 leads to a nonsense mutation in Su(var)3-9.

(Romanov et al., 2023)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\MAPT^R406W.UAS

(Frost et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority live (with Su(var)3-9⁶)

(Romanov et al., 2023)

suppressor of variegation, with In(1)w^m4

(Sass and Henikoff, 1998)

suppressor of variegation, with In(2R)bw^VDe2

(Sass and Henikoff, 1998)

suppressor of variegation, with P{wA^R}A

(Balasov et al., 2000)

suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

suppressor of variegation | dominant, with In(1)w^m4h

(Qi et al., 2006, Tschiersch et al., 1994, Reuter et al., 1986)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

suppressor of variegation | dominant, with P{lacW}50C.x6

(Maines et al., 2007)

suppressor of variegation | dominant, with T(1;4)w^m258-21

(Qi et al., 2006)

viable

(Reuter et al., 1986)

Phenotype Manifest In

Detailed Description

Statement

Reference

Animals homozygous for In(1)w^m4 and heterozygous for Su(var)3-9¹ have red eyes.

(Vogel et al., 2009)

One copy of Su(var)3-9¹ strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Su(var)3-9¹ moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Heterozygotes show no effect on crossing over between kni and p^p.

(Westphal and Reuter, 2002)

Suppresses the position effect variegation at the w locus caused by In(1)w^m4 and suppresses the position effect variegation at the bw locus caused by In(2R)bw^VDe2. Does not effect position effect variegation at the bw locus caused by Byron or the position effect variegation of w seen in the P{wA^R}41A insertion.

(Sass and Henikoff, 1998)

Strong suppressors of bw and w position effect variegation (PEV).

(Tschiersch et al., 1994)

Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4h.

(Reuter et al., 1986)

homozygous viable homozygous fertile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(var)3-9¹/Su(var)3-9[+] is an enhancer of increased cell death phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

Suppressor of

Statement

Reference

Su(var)3-9¹/Su(var)3-9[+] is a suppressor of partially lethal - majority live phenotype of ct^A, lncRNA:flam^A

(Guida et al., 2016)

Su(var)3-9¹/Su(var)3-9[+] is a suppressor of enhancer of variegation | dominant phenotype of Kdm5¹⁰⁴²⁴

(Di Stefano et al., 2011)

Su(var)3-9¹/Su(var)3-9[+] is a suppressor of lethal | recessive phenotype of JIL-1^z2

(Deng et al., 2007)

Su(var)3-9¹/Su(var)3-9² is a suppressor of lethal | recessive phenotype of JIL-1^z2

(Deng et al., 2007)

Su(var)3-9¹/Su(var)3-9[+] is a suppressor | partially of lethal phenotype of JIL-1^z60/JIL-1^z2

(Zhang et al., 2006)

Other

Statement

Reference

Df(2R)Dll-MP/egg¹⁴⁷³, Su(var)3-9¹/Su(var)3-9⁶ has lethal phenotype

(Romanov et al., 2023)

Df(2R)Dll-MP/egg¹⁴⁷³, Su(var)3-9¹/Su(var)3-9⁶ has some die during P-stage phenotype

(Romanov et al., 2023)

Df(2R)Dll-MP/egg¹⁴⁷³, Su(var)3-9¹/Su(var)3-9⁶ has some die during larval stage phenotype

(Romanov et al., 2023)

Df(2R)Dll-MP/egg¹⁴⁷³, Su(var)3-9¹/Su(var)3-9⁶ has visible | P-stage phenotype

(Romanov et al., 2023)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(var)3-9¹/Su(var)3-9[+] is an enhancer of neuron phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

Su(var)3-9¹ is an enhancer of eye phenotype of Hers^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Ito et al., 2012)

Suppressor of

Statement

Reference

Su(var)3-9¹/Su(var)3-9[+] is a suppressor of polytene chromosome phenotype of JIL-1^z2

(Deng et al., 2007)

Su(var)3-9¹/Su(var)3-9² is a suppressor of polytene chromosome phenotype of JIL-1^z2

(Deng et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

flam^A, ct^A double homozygotes display significant mortality during the pharate stage as compared to controls, which is suppressed by Su(var)3-9¹ heterozygosity.

(Guida et al., 2016)

The Scer\GAL4^GMR.PU, Hers^{Scer\UAS.T:Zzzz\FLAG} rough eye phenotype is significantly enhanced by Su(var)3-9¹.

(Ito et al., 2012)

Su(var)3-9¹/+ suppresses the ability of lid¹⁰⁴²⁴/+ to enhance the variegation at the w locus which is seen in the In(1)w^m4 chromosome.

(Di Stefano et al., 2011)

The lethality of JIL-1^z2 homozygotes is significantly suppressed by one copy of Su(var)3-9¹ (87.4% viability).

The lethality of JIL-1^z2 homozygotes is significantly suppressed by Su(var)3-9¹/Su(var)3-9² (55.8% viability).

The abnormal polytene chromosome morphology seen in JIL-1^z2 homozygous third instar larvae is partially suppressed by Su(var)3-9¹/+ or Su(var)3-9¹/Su(var)3-9²; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants.

(Deng et al., 2007)

JIL-1^z2/JIL-1^z60 flies that have one copy of the Su(var)3-9¹ allele show greater levels of survival compared to those that carry two wild-type copies of Su(var)3-9.

(Zhang et al., 2006)

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

(McKee et al., 2000)

Xenogenetic Interactions

Statement

Reference

Heterozygous Su(var)3-9¹ enhances the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} induced neuronal apoptosis.

(Frost et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

6209

In(1)w^m4; Su(var)3-9¹/TM3, Sb¹ Ser¹

Kyoto

108675

Su(var)3-9¹/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Comments

Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)w^m4h, and a dominant enhancer of position effect variegation, E(var)c101¹.

(Reuter et al., 1986)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ290956

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

3-9¹

(Doheny et al., 2008, McKee et al., 2000)

Su(Var)3-9¹

(Lee and Spradling, 2014)

Su(var)3-9⁰¹

(Romanov et al., 2023, Vasanthi et al., 2013, Brower-Toland et al., 2009, Vogel et al., 2009, Ebert et al., 2004, Westphal and Reuter, 2002, Hwang et al., 2001, Balasov et al., 2000, Sass and Henikoff, 1998)

Su(var)3-9¹

(Goupil et al., 2022, Martins et al., 2019, Song et al., 2018, Guida et al., 2016, Frost et al., 2014, Debruhl et al., 2013, Ito et al., 2012, Nowak et al., 2012, Boeke et al., 2011, Di Stefano et al., 2011, Paredes and Maggert, 2009, Scaria et al., 2008, Zhang et al., 2008, Deng et al., 2007, Maines et al., 2007, Qi et al., 2006)

Su(var)¹

(Scaria et al., 2008)

Su-var(3)9⁰¹

(Reuter et al., 1986)

su(var)3-9¹

(Hong and Choi, 2016)

Name Synonyms

Secondary FlyBase IDs

References (32)

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