FlyBase Allele Report: Dmel\JIL-1[z60]

Imprecise excision which leaves the P{EP} promoter region intact but removes the entire JIL-1 promoter and the 5' untranslated region. Proximal genomic sequences upstream of JIL-1, extending to a region between nucleotides 207,742 and 269,371 of AE003546 (release 3.0, GI:23093654 ) are also removed, resulting in the complete deletion of the CG6279 coding sequence.

(Zhang et al., 2003)

Imprecise excision of the P{EP} element (the 5' end has been excised), removing a portion of the JIL-1 sequence (the 5' untranslated sequence and putative promoter region).

(Wang et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

enhancer of variegation, with P{hsp26-pt-T}39C-3

(Bao et al., 2007)

enhancer of variegation, with P{hsp26-pt-T}118E-10

(Bao et al., 2007)

enhancer of variegation, with P{hsp26-pt-T}118E-25

(Bao et al., 2007)

enhancer of variegation, with P{hsp26-pt-T}118E-32

(Bao et al., 2007)

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}39C-3

(Bao et al., 2007)

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-10

(Bao et al., 2007)

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-25

(Bao et al., 2007)

enhancer of variegation (with JIL-1^z2), with P{hsp26-pt-T}118E-32

(Bao et al., 2007)

lethal (with JIL-1^z2)

(Zhang et al., 2006)

lethal | recessive

(Wang et al., 2001, Wang et al., 2001)

partially lethal - majority die (with JIL-1^z2)

(Bao et al., 2007, Lerach et al., 2006)

suppressor of variegation, with In(1)w^m4

(Lerach et al., 2006)

suppressor of variegation (with JIL-1^z2), with In(1)w^m4

(Lerach et al., 2006)

Phenotype Manifest In

polytene chromosome

(Wang et al., 2001)

Detailed Description

Statement

Reference

Only 1 out of 871 JIL-1^z2/JIL-1^z60 flies eclose.

(Zhang et al., 2006)

Eclosion rate is less than 3%.

(Wang et al., 2001)

Homozygous larvae have an eclosion rate of 0.5%. The number of males eclosing is 32% that of females. The polytene chromosome banding pattern is perturbed in homozygous third instar larvae. Perturbation of the male X chromosome is relatively more severe than that of the autosomes.

(Wang et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

JIL-1^z60/JIL-1^z2 has lethal phenotype, suppressible | partially by Su(var)3-9¹/Su(var)3-9[+]

(Zhang et al., 2006)

Suppressor of

Statement

Reference

JIL-1^z60/JIL-1^z60 is a suppressor | partially of enhancer of variegation | dominant phenotype of E(var)2-1¹, In(1)w^m4

(Lerach et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

JIL-1^z2/JIL-1^z60 flies that have one copy of the Su(var)3-9¹ allele show greater levels of survival compared to those that carry two wild-type copies of Su(var)3-9.

(Zhang et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

General trend from least to most viable is: JIL-1^z2 < JIL-1^h9 < JIL-1^z60 < JIL-1^EP3657 < JIL-1^z28 ~ JIL-1^Scim.

(Zhang et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

JIL-1^Z60

JIL-1^z60

(Silva-Sousa and Casacuberta, 2013, Bao et al., 2007, Lerach et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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