FlyBase Allele Report: Dmel\Su(var)3-9[2]

General Information

Symbol

Dmel\Su(var)3-9²

Species

D. melanogaster

Name

FlyBase ID

FBal0016558

Feature type

allele

Associated gene

Dmel\Su(var)3-9

Associated Insertion(s)

Carried in Construct

Also Known As

Su(var)3-9⁰²

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Zhang et al., 2006, Ebert et al., 2004)

Mutagen

ethyl methanesulfonate

(Reuter et al., 1986)

Progenitor genotype

Cytology

Description

Amino acid replacement: C427Y.

(Krauss et al., 2006)

Point mutation.

(Ebert et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,260,859..15,260,859 [-]

Nucleotide change:

G15260859A

Amino acid change:

C427Y | Su(var)3-9-PA

Reported amino acid change:

C427Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Krauss et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\MAPT^R406W.UAS

(Frost et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

non-suppressor of variegation | dominant, with P{hsp26-pt-T}8-M76

(Wang et al., 2014)

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-66

(Wang et al., 2014)

suppressor of variegation | dominant, with In(1)w^m4h

(Tschiersch et al., 1994, Reuter et al., 1986)

viable

(Reuter et al., 1986)

Phenotype Manifest In

Detailed Description

Statement

Reference

Strong suppressors of bw and w position effect variegation (PEV).

(Tschiersch et al., 1994)

Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4h.

(Reuter et al., 1986)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(var)3-9[+]/Su(var)3-9² is an enhancer of increased cell death phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

Su(var)3-9[+]/Su(var)3-9² is an enhancer of abnormal locomotor behavior phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

Suppressor of

Statement

Reference

Su(var)3-9[+]/Su(var)3-9² is a suppressor | partially of partially lethal - majority live phenotype of ct^A, lncRNA:flam^A

(Guida et al., 2016)

Su(var)3-9[+]/Su(var)3-9² is a suppressor of lethal | recessive phenotype of JIL-1^z2

(Deng et al., 2007)

Su(var)3-9¹/Su(var)3-9² is a suppressor of lethal | recessive phenotype of JIL-1^z2

(Deng et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(var)3-9[+]/Su(var)3-9² is an enhancer of neuron phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

Suppressor of

Statement

Reference

Su(var)3-9[+]/Su(var)3-9² is a suppressor of polytene chromosome phenotype of JIL-1^z2

(Deng et al., 2007)

Su(var)3-9¹/Su(var)3-9² is a suppressor of polytene chromosome phenotype of JIL-1^z2

(Deng et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Su(var)3-9² heterozygosity partially suppresses the mortality exhibited by flam^A, ct^A double homozygotes.

(Guida et al., 2016)

The lethality of JIL-1^z2 homozygotes is significantly suppressed by one copy of Su(var)3-9² (50.7% viability).

The lethality of JIL-1^z2 homozygotes is significantly suppressed by Su(var)3-9¹/Su(var)3-9² (55.8% viability).

The abnormal polytene chromosome morphology seen in JIL-1^z2 homozygous third instar larvae is partially suppressed by Su(var)3-9²/+ or Su(var)3-9¹/Su(var)3-9²; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants.

(Deng et al., 2007)

Xenogenetic Interactions

Statement

Reference

Heterozygous Su(var)3-9² enhances the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS} induced neuronal apoptosis and locomotory defects.

(Frost et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

6210

In(1)w^m4; Su(var)3-9²/TM3, Sb¹ Ser¹

Kyoto

108676

Su(var)3-9²/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Comments

Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)w^m4h, and a dominant enhancer of position effect variegation, E(var)c101¹.

(Reuter et al., 1986)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ290956

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

(Krauss et al., 2006)

Su(Var)3-9²

(Lee and Spradling, 2014)

Su(var)3-902

(Netter et al., 1998)

Su(var)3-9⁰²

(Wang et al., 2014, Brower-Toland et al., 2009, Ebert et al., 2004)

Su(var)3-9²

(Delanoue et al., 2023, Guida et al., 2016, Xing and Li, 2015, Frost et al., 2014, Boeke et al., 2011, Skora and Spradling, 2010, Scaria et al., 2008, Zhang et al., 2008, Deng et al., 2007)

Su(var)²

(Scaria et al., 2008)

Su-var(3)902

(Fauvarque and Dura, 1993)

Su-var(3)9⁰²

(Reuter et al., 1986)

su(var)3-9²

(Hong and Choi, 2016)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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