Amino acid replacement: E173K.
G9697050A
E173K | Pka-C1-PB; E173K | Pka-C1-PC; E173K | Pka-C1-PD
E173K
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
lethal (with Pka-C1Cos-1)
lethal (with Pka-C1Cos-2)
lethal (with Pka-C1Cos-4)
lethal (with Pka-C1Cos-8)
lethal (with Pka-C1Cos-9)
Class II allele; lethal when homozygous or in heteroallelic combination with other class II alleles.
Local pattern duplications of wing and haltere.
Df(2R)CA58, Pka-C1Cos-3 has partially lethal - majority live phenotype
Pka-C1Cos-3, Pka-R2Cos-A1 has viable phenotype
Pka-C1Cos-3, Pka-R2Cos-A1R+1A has viable phenotype
Pka-C1Cos-3, cosV1 has lethal | maternal effect | embryonic stage phenotype
Pka-C1Cos-3, cosV2 has lethal | maternal effect | embryonic stage phenotype
Pka-C1Cos-3, cosV3 has lethal | maternal effect | embryonic stage phenotype
Pka-C1Cos-3, cosV4 has lethal | maternal effect | embryonic stage phenotype
Df(2R)CA58, Pka-C1Cos-3 has wing phenotype
Wings are duplicated when transheterozygous with Df(2R)CA58 (cos-). The phenotype of embryos resulting from crosses involving viable alleles of cos and Pka-C1Cos-2 or Pka-C1Cos-3 indicate a maternal effect on the interaction between Pka-C1 and cos. If the female parent is heterozygous for a viable allele of cos and Pka-C1Cos-2 or Pka-C1Cos-3, and the male parent for Pka-C1Cos-2 or Pka-C1Cos-3, 11% of the embryos show a strong bicaudal phenotype (whereas the reciprocal cross produces less than 1% bicaudal embryos).
Simpson.
Penetrance and expressivity are variable. The pattern duplications seen in flies heterozygous for neomorphic "Cos" alleles are indistinguishable from those seen in flies homozygous for leaky alleles of cos.