Amino acid replacement: E130K.
G9697179A
E130K | Pka-C1-PB; E130K | Pka-C1-PC; E130K | Pka-C1-PD
E130K
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
lethal (with Pka-C1Cos-1)
lethal (with Pka-C1Cos-2)
lethal (with Pka-C1Cos-3)
lethal (with Pka-C1Cos-4)
lethal (with Pka-C1Cos-8)
Class II allele; lethal when homozygous or in heteroallelic combination with other class II alleles.
Local pattern duplications of wing and haltere.
Pka-C1Cos-9, Pka-R2Cos-A1 has viable phenotype
Pka-C1Cos-9, Pka-R2Cos-A1R+1A has viable phenotype
Df(2R)CA58, Pka-C1Cos-9 has partially lethal - majority live phenotype
Df(2R)CA58, Pka-C1Cos-9 has wing phenotype
Wings are duplicated when transheterozygous with Df(2R)CA58 (cos-).
C. Nusslein-Volhard.
Penetrance and expressivity are variable. The pattern duplications seen in flies heterozygous for neomorphic "Cos" alleles are indistinguishable from those seen in flies homozygous for leaky alleles of cos.