FB2024_03 , released June 25, 2024
Allele: Dmel\cosV1
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General Information
Symbol
Dmel\cosV1
Species
D. melanogaster
Name
FlyBase ID
FBal0001778
Feature type
allele
Associated gene
Dmel\cos
Associated Insertion(s)
?{}cosV1
Carried in Construct
Also Known As
cos2V1, cos-2V1
Key Links
Genomic Maps

Allele class

wild-type allele

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Grau and Simpson, 1987)

wild-type allele

(Preat et al., 1993)
Mutagen
spontaneous
Progenitor genotype
Associated Insertion(s)
?{}cosV1
Cytology
Description

9kb insertion at position +112, at the 3' end of the cos transcription unit.

(Sisson et al., 1997)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cosV1/cosV5 females show duplication of the dorsal vaginal plate with an increment in the number of sensilla trichodea and loss of the ventral vaginal plate. The eighth tergite and vulva are reduced. Anal plates are abnormal. cosV1/cosV5 males show fusion of the lateral plates and the claspers. The hypandrium phragma is reduced.

      (Sanchez et al., 1997)

      Displays adult pattern duplications in the presence of semidominant alleles of "Cos".

      (Sisson et al., 1997)

      Viable mutation. Wing phenotype is similar to the phenotype resulting from ectopic expression of hhScer\UAS.cCa, induction of overgrowth with a mirror image duplication of structures of the anterior and posterior compartments.

      (Capdevila and Guerrero, 1994)

      Phenotypic interactions when in combination with cos.

      (Preat et al., 1993)

      class III allele cosV5 >= cosV4 = cosV1 >= cosV2 >= cosV3

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cosV1 Pka-R2Cos-A1 double heterozygotes show a large duplication of the costa region in the wing. The duplication contains triple-row and double-row bristles, indicating it consists of anterior structures.

      (Collier et al., 2004)

      Pka-C1Cos-2 cosV1/cosV5 flies have abnormal legs. fuJ; Pka-C1Cos-2 cosV1/cosV5 flies show a cos phenotype in the thorax and legs.

      (Sanchez-Herrero et al., 1996)

      cosV1 Pka-C1Cos-2/+ individuals display severe outgrowth of the anterior compartment of the wing disc.

      (Capdevila et al., 1994)

      The phenotype of embryos resulting from crosses involving viable alleles of cos and Pka-R2Cos-A1, Pka-C1Cos-2 or Pka-C1Cos-3 indicate a maternal effect on the interaction between cos and Pka-C1 and the interaction between cos and Pka-R2. If the female parent is heterozygous for a viable allele of cos and Pka-R2Cos-A1, Pka-C1Cos-2 or Pka-C1Cos-3, and the male parent for Pka-R2Cos-A1, Pka-C1Cos-2 or Pka-C1Cos-3, 11% of the embryos show a strong bicaudal phenotype (whereas the reciprocal cross produces less than 1% bicaudal embryos).

      (Grau and Simpson, 1987)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Simpson.

      Isolated from: Various laboratory stocks.

      Comments
      Comments

      "spontaneous" was stated as tentative.

      Isolated by recombination from a laboratory stock. Allelic series: cosV5 >= cosV4 = cosV1 >= cosV2 >= cosV3, based on the penetrance of wing duplications.

      (Grau and Simpson, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (11)