Dickson, B.J., van der Straten, A., Dominguez, M., Hafen, E. (1996). Mutations modulating Raf signaling in Drosophila eye development. Genetics 142(1): 163--171.
FlyBase ID
FBrf0086382
Publication Type
Research paper
Abstract
The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.
