Amino acid replacement: Y214F.
A18248077T
Y214F | 14-3-3epsilon-PA; Y214F | 14-3-3epsilon-PB; Y214F | 14-3-3epsilon-PC; Y214F | 14-3-3epsilon-PD
Y214F
Homozygous embryos show highly penetrant axon guidance defects in the ISNb and SNa axons. The axon guidance defects are characterised by inappropriate defasciculation.
Homozygotes have no detectable phenotype in a wild-type background.
Homozygous viable with no obvious defects in eye development.
14-3-3ε18A2, Raf12 has lethal | dominant phenotype
14-3-3ε18A2 is a suppressor of eye phenotype of Raf::tor12D.sev
Dominantly suppresses the rough eye phenotype of phl::tor12D.sev. Synthetic lethal in combination with phl12.