l(2)00632, Su(Raf)2A, SS2-1, l(2)23Cc, SY2-1
transcription factor - Fragile X mental retardation 2 (Fmr2) family - Functions in MAPK and Dpp signaling pathways - affects growth, a function associated with the insulin pathway - affects the cytoskeleton early in development.
Please see the JBrowse view of Dmel\lilli for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.13
Component of the super elongation complex (SEC), at least composed of Ell, Cdk9, cyclin-T (CycT), lilli and ear.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lilli using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\lilli in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Embryos lacking maternal lilli function show specific defects in the establishment of a functional cytoskeleton during cellularisation, and show a pair-rule segmentation phenotype.
Loss of lilli function causes an autonomous reduction in cell size.
Maternal contribution of the lilli gene is important for formation of segmentation pattern during embryogenesis.
lilli homozygous clones produce small cells.
40 "SS2-1" alleles of lilli have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype.
Identified in a genetic screen for modifiers of the phl::tor12D.sev rough eye mutant phenotype. Clonal analysis reveals that lilli is not required for normal eye development.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
Source for merge of: lilli SY2-1 Su(Raf)2A l(2)k07920
Source for merge of: lilli l(2)23Cc
Source for merge of: lilli BEST:GH09955
Source for merge of: lilli BcDNA:GM02019
Source for identity of lilli CG8817 was sequence comparison ( date:010129 ).
Source for merge of lilli BcDNA:GM02019 was a shared cDNA ( date:030728 ).
Source for identity of: lilli CG8817
The gene is named "lilliputian" based on the small size of homozygous mutant cells.
