FlyBase Gene Report: Dmel\nbs

FB2024_02 , released April 23, 2024

FB2024_02 , released April 23, 2024

Gene: Dmel\nbs

General Information

Symbol

Dmel\nbs

Species

D. melanogaster

Name

nbs

Annotation Symbol

CG6754

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261530

Gene Model Status

Stock Availability

10 publicly available

Gene Summary

nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)67BDp, NBS1, l(3)67BDr, Nijmegen breakage syndrome

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:9,720,414..9,723,194 [-]

Recombination map

3-31

RefSeq locus

NT_037436 REGION:9720414..9723194

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables damaged DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000255549

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in DNA repair

inferred from mutant phenotype

(Ciapponi et al., 2006)

involved_in double-strand break repair via synthesis-dependent strand annealing

inferred from mutant phenotype

(Mukherjee et al., 2009)

involved_in intrinsic apoptotic signaling pathway in response to DNA damage

inferred from mutant phenotype

(Oikemus et al., 2006)

involved_in mitotic G2 DNA damage checkpoint signaling

inferred from mutant phenotype

(Mukherjee et al., 2009)

involved_in signal transduction in response to DNA damage

inferred from mutant phenotype

(Oikemus et al., 2006)

involved_in telomere maintenance

inferred from mutant phenotype

(Gao et al., 2009, Ciapponi et al., 2006, Bi et al., 2005)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in DNA duplex unwinding

inferred from biological aspect of ancestor with PANTHER:PTN000255549

(GO Reference Genome Project, 2011-)

involved_in double-strand break repair via homologous recombination

inferred from biological aspect of ancestor with PANTHER:PTN000255549

(GO Reference Genome Project, 2011-)

involved_in double-strand break repair

inferred from electronic annotation with InterPro:IPR040227

(InterPro Project Members, 2004-)

involved_in mitotic G2 DNA damage checkpoint signaling

inferred from biological aspect of ancestor with PANTHER:PTN000255549

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR040227

(InterPro Project Members, 2004-)

involved_in telomere maintenance

inferred from electronic annotation with InterPro:IPR016592

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of Mre11 complex

inferred from direct assay

(Gao et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of Mre11 complex

inferred from biological aspect of ancestor with PANTHER:PTN000255549

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR016592, InterPro:IPR040227

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR040227

(InterPro Project Members, 2004-)

located_in nucleus

inferred from electronic annotation with InterPro:IPR016592

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions. [Date last reviewed: 2019-02-28]

Gene Group (FlyBase)

MRN COMPLEX -: The MRN complex consists of the two evolutionarily conserved components (Mre11 and Rad50) and a third less-conserved component (Nbs1/Xrs2). This complex mediates telomere maintenance in addition to a variety of functions in response to DNA double-strand breaks, including homologous recombination, nonhomologous end joining (NHEJ), and activation of DNA damage checkpoints. RAD50 provides ATP-dependent regulatory control of Mre11 nuclease activity by unwinding and/or repositioning DNA ends into the Mre11 active site. (Adapted from FBrf0180055 and PMID:17698079.)

Summary (Interactive Fly)

encodes a multifunctional protein that plays critical roles in the response to DNA damage and telomere maintenance - part of a protein complex, MRN, that senses DNA strand breaks and amplifies the signal and then conveys it to downstream effectors, such as ATM and p53, that regulate cell cycle checkpoints and DNA repair

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\nbs for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VT40)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Mutation in sequenced strain; single base change at splice site. Alternative downstream splice donor may be used.

Gene model reviewed during 6.02

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.04

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0306039

2593

816

FBtr0306040

2599

818

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0297181

91.2

816

7.96

FBpp0297182

91.5

818

8.12

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nbs using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nbs_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.05

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Mre11 complex

inferred from direct assay

(Gao et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nbs in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nbs

View exonic expression by tissue for Dmel\nbs

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44259/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261530

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086349

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261530

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6754

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nbs

Transgenic constructs containing regulatory region of nbs

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

(Andrade and Cook, 2003.12.11)

Gene partially disrupted in

(Rutkowski and Warren, 2009)

Gene duplicated in

Dp(3;3)Walkman-nbs-Ilp

(Wesolowska and Rong, 2013)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

nbs²

lethal | larval stage | recessive

nbs¹

lethal | pupal stage | recessive

nbs¹

lethal - all die before end of P-stage

nbs¹

lethal - all die before end of P-stage (with nbs¹)

nbs²

lethal - all die before end of P-stage (with nbs²)

nbs¹

lethal - all die before end of pupal stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nbs^GD12399

viable, with Scer\GAL4^Mef2.PR

nbs^GD12399

viable, with Scer\GAL4^pnr-MD237

nbs^GD12399

viable, with Scer\GAL4^tin.CΔ4

nbs^GD12399

viable (with nbs¹)

nbs^EY15506

viable (with nbs^EY15506)

nbs¹

Sterility

Allele

nbs^2K

nbs^2K

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

nbs^GD12399

abnormal DNA repair (with nbs¹)

nbs^SM9

abnormal DNA repair (with nbs^SM9)

nbs¹

abnormal DNA repair | dominant

nbs¹

abnormal mitotic cell cycle

nbs^2K

abnormal mitotic cell cycle (with Df(3R)PG4)

nbs¹

abnormal mitotic cell cycle | larval stage

nbs¹

increased cell death

nbs¹

increased cell death (with nbs¹)

nbs²

increased cell death (with nbs²)

nbs¹

radiation sensitive

nbs¹

radiation sensitive (with nbs¹)

radiation sensitive (with nbs^EY15506)

nbs¹

radiation sensitive (with nbs^SM9)

nbs¹

some die during pharate adult stage

nbs¹

some die during pharate adult stage (with nbs¹)

nbs²

some die during pharate adult stage (with nbs²)

nbs¹

some die during pupal stage | recessive

Phenotype manifest in

Allele

chromosome

nbs^2K

chromosome, telomeric region

nbs¹

chromosome, telomeric region (with Df(3L)AC1)

nbs¹

chromosome & neuroblast | third instar larval stage 2

nbs¹

chromosome | larval stage

nbs¹

condensed chromosome

nbs¹

condensed chromosome (with Df(3L)AC1)

nbs¹

embryonic/larval brain | third instar larval stage

nbs¹

nbs¹

eye (with nbs¹)

nbs²

eye (with nbs²)

nbs¹

nbs¹

larval neuroblast

nbs¹

nbs¹

macrochaeta (with nbs¹)

nbs²

macrochaeta (with nbs²)

nbs¹

mesothoracic tergum, with Scer\GAL4^pnr-MD237

nbs^GD12399

nuclear chromosome | third instar larval stage

nbs¹

nbs^2K

nbs¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

9 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

10 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

10 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (1)

4 of 13

Yes

Yes

Danio rerio (Zebrafish) (1)

9 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP003213

8 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (1)

5 of 13

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

1 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nbs. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Nijmegen breakage syndrome

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

model of acute lymphoblastic leukemia

IEA

(FlyBase, 2019-)

model of Nijmegen breakage syndrome

IEA

(FlyBase, 2019-)

model of aplastic anemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{T12.Aβ42.UAS.Tag:SS(nec)}

(Tuxworth et al., 2019)

ameliorates Huntington's disease

modeled by Hsap\HTT^128Q.FL.UAS

(Tuxworth et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

9 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

On

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, western blot

(Dronamraju and Mason, 2009)

nbs - Su(var)205

anti tag coimmunoprecipitation, western blot, pull down

(Bosso et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot

(On et al., 2021)

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(On et al., 2021, Kusch, 2015, Gao et al., 2009)

pull down, western blot

(Dronamraju and Mason, 2009)

anti bait coimmunoprecipitation, western blot

(Gao et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Oikemus et al., 2006)

suppressible

(Oikemus et al., 2006)

enhanceable

(Ciapponi et al., 2006, Bi et al., 2005)

enhanceable

(Gao et al., 2009)

enhanceable

(Oikemus et al., 2006)

suppressible

(Oikemus et al., 2006)

enhanceable

(Ciapponi et al., 2006)

enhanceable

(Ciapponi et al., 2006)

suppressible

(Oikemus et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Oikemus et al., 2006)

enhanceable

(Ciapponi et al., 2006)

enhanceable

(Gao et al., 2009)

enhanceable

(Oikemus et al., 2006)

enhanceable

(Ciapponi et al., 2006)

enhanceable

(Ciapponi et al., 2006)

suppressible

(Oikemus et al., 2006)

suppressible

(Merigliano et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261530

MIST (genetic) - An integrated Molecular Interaction Database

44259

MIST (protein-protein) - An integrated Molecular Interaction Database

44259

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Homologous recombination

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VT40

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-31

Cytogenetic map

Sequence location

3L:9,720,414..9,723,194 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C5-67C5

Limits computationally determined from genome sequence between P{PZ}fry⁰²²⁴⁰ and P{lacW}l(3)L0539^L0539&P{PZ}Dhh1^rL562

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

67C10-67D1

(Flores, 1999.3.11)

Experimentally Determined Recombination Data

Location

3-31

(FlyBase, 2016)

3-24.1

(Comeron et al., 2012)

3-[28]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

21141

y¹ w^67c23; P{EPgy2}nbs^EY15506

2554

nbs¹ kni^ri-1 p^p/TM3, Sb¹

2557

nbs² kni^ri-1 p^p/TM3, Sb¹

84004

y¹ sc^* v¹ sev²¹; P{TKO.GS04120}attP40

65971

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06251}attP40

107399

nbs¹ kni^ri-1 p^p/TM3, Sb¹

107401

nbs² kni^ri-1 p^p/TM3, Sb¹

v110366

P{KK101013}VIE-260B

v28215

w¹¹¹⁸; P{GD12399}v28215

v28216

w¹¹¹⁸; P{GD12399}v28216

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (81)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD44438

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261530

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261530

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Bosso et al., 2019)

polyclonal

(Gao et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

nbs is required to maintain chromosome integrity and to prevent telomere fusion. nbs mediates transport of the mre11/rad50 complex in the nucleus. nbs and the mre11/rad50 complex play partially independent roles in telomere protection and nbs appears to function in both mei-41- and tefu-controlled telomere protection pathways.

(Ciapponi et al., 2006)

nbs is essential for cell cycle arrest at high doses of X-irradiation.

(Oikemus et al., 2006)

Identification: Defined on basis of DNA sequence similarity to NBS (Nijmegen Breakage Syndrome).

(Flores and Engels, 1999)

Relationship to Other Genes

Source for database merge of

Source for merge of: nbs CG6754

(Flores, 2000.6.9)

Source for merge of: nbs l(3)67BDp

(Ciapponi et al., 2006)

Source for merge of: nbs l(3)67BDr

(Oikemus et al., 2006)

Additional comments

FlyBase curator comment: the insertion in the "c06100" Exelixis line (PBac{PB}defl^c06100) was originally assigned to the nbs gene in FBrf0179797, resulting in the "nbs^c06100" (FBal0158901) allele. However, FBrf0184340 shows that the insertion is actually within defl.

(Bloomington Drosophila Stock Center, 2004.11.6)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

6754

(Ravi et al., 2009)

CG6754

(Keleman et al., 2009.8.5, Perkins et al., 2009, Flores, 2000.6.9)

Dnbs1

(Rutkowski and Warren, 2009)

NBS

(Klucnika et al., 2023, Dronamraju and Mason, 2009)

NBS1

(Colmenares et al., 2017, Li et al., 2013, Kondo and Perrimon, 2011)

Nbs

(Láscarez-Lagunas et al., 2020, Mira and Morante, 2020, Bosso et al., 2019, Kusch, 2015, Raffa et al., 2013, Kurzhals et al., 2011, Raffa et al., 2011, Gao et al., 2008, Hochwagen, 2006)

Nbs1

(Bosso et al., 2019, Bangash et al., 2005)

dNbs1

(Porrazzo et al., 2022)

l(3)67BDp

(Ciapponi et al., 2006, Bi et al., 2005, Bi et al., 2005)

l(3)67BDr

(Oikemus et al., 2006)

l(3)e77A1

nbs

(Hersperger et al., 2024, Cancian et al., 2022, Porrazzo et al., 2022, Porrazzo et al., 2022, Hagen et al., 2021, Khan et al., 2019, Meltzer et al., 2019, Tuxworth et al., 2019, Hall et al., 2018, Merigliano et al., 2017, Sekelsky, 2017, Transgenic RNAi Project members, 2017-, Bennett et al., 2015, Cenci et al., 2015, Morciano et al., 2013, Raffa et al., 2013, Wesolowska et al., 2013, Beaucher et al., 2012, Kondo and Perrimon, 2011, Kurzhals et al., 2011, Lafave and Sekelsky, 2011, Gao et al., 2010, Iijima et al., 2010, Dronamraju and Mason, 2009, Gao et al., 2009, Gao et al., 2009, Mukherjee et al., 2009, Rutkowski and Warren, 2009, Gao et al., 2008, Mavrich et al., 2008, Rong, 2008, Oikemus et al., 2007, Ciapponi et al., 2006, Oikemus et al., 2006, Bi et al., 2005, Bi et al., 2005, Stanyon et al., 2004)

nbs1

(Colmenares et al., 2017)

Name Synonyms

Nijmegen breakage syndrome

(Bi et al., 2005)

lethal (3) 67BDp

lethal (3) 67BDr

nbs

Secondary FlyBase IDs

FBgn0002220
FBgn0086349
FBgn0026198
FBgn0002218
FBgn0036037

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44259

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VT40

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VT40

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44259/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261530

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261530

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6754

MARRVEL_MODEL - MARRVEL (model organism gene)

44259

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261530

DroID - A comprehensive database of gene and protein interactions.

FBgn0261530

DRSC - Results frm RNAi screens

FBgn0261530

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nbs_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0086349

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261530

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6754

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261530

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013036

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Homologous recombination

MIST (genetic) - An integrated Molecular Interaction Database

44259

MIST (protein-protein) - An integrated Molecular Interaction Database

44259

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VT40

References (88)