FlyBase Allele Report: Dmel\htt[int]

General Information

Symbol

Dmel\htt^int

Species

D. melanogaster

Name

FlyBase ID

FBal0324927

Feature type

allele

Associated gene

Dmel\htt

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ends-in gene targeting

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Dietz et al., 2015)

Mutagen

ends-in gene targeting

(Dietz et al., 2015)

Progenitor genotype

Cytology

Description

Targeting event that has resulted in a partial duplication of the htt locus. The sequence consists of 1. htt exons 1 through 8, in which exons 3 and 4 and part of exon 5 have been deleted, 2. a mini-w[+] marker and 3. exons 2 through to the 3' end of the htt transcription unit.

(Dietz et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

suppressor of variegation, with In(1)y^3P

(Dietz et al., 2015)

suppressor of variegation, with T(2;3)Sb^V

(Dietz et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

The longevity of htt^int mutant adult flies is comparable to wild-type.

The positional effect variegation (PEV) at the Sb locus caused by T(2;3)Sb^V or at the y locus caused by In(1)y^3P is significantly suppressed by single copy of htt^int.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

htt^int is an enhancer of visible | adult stage phenotype of Su(var)3-3^ΔN

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of HP1b^KK108772, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int/htt[+] is an enhancer of visible | adult stage phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PF

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Jarid2^JF02081, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^en.PU, Su(z)12^JF01706

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^en.PU, ash1^JF01498

(Dietz et al., 2015)

htt^int is an enhancer of visible phenotype of Scer\GAL4^en.PU, Su(var)3-3^GD9296

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^nub.PK, trx^JF01557

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Mt2^GD5033, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^nub.PK, brm^GD4507

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^en.PU, brm^GD4507

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^nub.PK, brm^HM04019

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Scer\GAL4^en.PU, gpp^JF01283

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of Rga^GL00386, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of HDAC1^JF01401, Scer\GAL4^ey.PH

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of HDAC1^JF01401, Scer\GAL4^nub.PK

(Dietz et al., 2015)

htt^int is an enhancer of visible | adult stage phenotype of HP1b^KK108772, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Suppressor of

Statement

Reference

htt^int is a suppressor of visible | adult stage phenotype of E(Pc)^JF03101, Scer\GAL4^ey.PH

(Dietz et al., 2015)

htt^int is a suppressor of visible | adult stage phenotype of E(Pc)^JF03101, Scer\GAL4^GMR.PF

(Dietz et al., 2015)

htt^int is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^en.PU, Su(var)205^KK110828

(Dietz et al., 2015)

htt^int is a suppressor of visible | adult stage phenotype of Orc2^KK102852, Scer\GAL4^nub.PK

(Dietz et al., 2015)

htt^int is a suppressor of visible | adult stage phenotype of Scer\GAL4^ey.PH, Sin3A^HMS00359

(Dietz et al., 2015)

htt^int is a suppressor of visible | adult stage phenotype of Scer\GAL4^en.PU, Sin3A^HMS00359

(Dietz et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

htt^int is an enhancer of posterior crossvein phenotype of Su(var)3-3^ΔN

(Dietz et al., 2015)

htt^int is an enhancer of wing vein phenotype of HP1b^KK108772, Scer\GAL4^nub.PK

(Dietz et al., 2015)

htt^int is an enhancer of wing vein phenotype of HP1b^KK108772, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int/htt[+] is an enhancer of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PF

(Dietz et al., 2015)

htt^int is an enhancer of wing vein phenotype of Jarid2^JF02081, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int is an enhancer of wing blade phenotype of Scer\GAL4^en.PU, Su(z)12^JF01706

(Dietz et al., 2015)

htt^int is an enhancer of wing phenotype of Scer\GAL4^en.PU, ash1^JF01498

(Dietz et al., 2015)

htt^int is an enhancer of wing blade phenotype of Scer\GAL4^nub.PK, trx^JF01557

(Dietz et al., 2015)

htt^int is an enhancer of wing phenotype of Mt2^GD5033, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int is an enhancer of wing blade phenotype of Scer\GAL4^nub.PK, brm^GD4507

(Dietz et al., 2015)

htt^int is an enhancer of wing blade phenotype of Scer\GAL4^en.PU, brm^GD4507

(Dietz et al., 2015)

htt^int is an enhancer of wing vein phenotype of Scer\GAL4^en.PU, Su(var)3-3^GD9296

(Dietz et al., 2015)

htt^int is an enhancer of wing blade phenotype of Scer\GAL4^nub.PK, brm^HM04019

(Dietz et al., 2015)

htt^int is an enhancer of wing phenotype of Scer\GAL4^en.PU, gpp^JF01283

(Dietz et al., 2015)

htt^int is an enhancer of wing vein phenotype of Rga^GL00386, Scer\GAL4^en.PU

(Dietz et al., 2015)

htt^int is an enhancer of ovary phenotype of Scer\GAL4^Act5C.PI, Su(var)3-3^GD9296

(Dietz et al., 2015)

htt^int is an enhancer of eye phenotype of HDAC1^JF01401, Scer\GAL4^ey.PH

(Dietz et al., 2015)

htt^int is an enhancer of wing blade phenotype of HDAC1^JF01401, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Suppressor of

Statement

Reference

htt^int/htt[+] is a suppressor of eye phenotype of Scer\GAL4^ey.PH, Sin3A^HMS00359

(Dietz et al., 2015)

htt^int is a suppressor of wing phenotype of Scer\GAL4^en.PU, Sin3A^HMS00359

(Dietz et al., 2015)

htt^int is a suppressor of eye phenotype of E(Pc)^JF03101, Scer\GAL4^ey.PH

(Dietz et al., 2015)

htt^int is a suppressor of eye phenotype of E(Pc)^JF03101, Scer\GAL4^GMR.PF

(Dietz et al., 2015)

htt^int is a suppressor | partially of wing margin phenotype of Scer\GAL4^en.PU, Su(var)205^KK110828

(Dietz et al., 2015)

htt^int is a suppressor of wing phenotype of Orc2^KK102852, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The ovarian defects observed in females expressing Su(var)3-3^GD9296 under the control of Scer\GAL4^Act5C.PI as well as the ectopic venation phenotype induced by Scer\GAL4^en.PU-driven expression of Su(var)3-3^GD9296 are enhanced by combination with htt^int.

The adult eye induced by expression of HDAC1^JF01401 under the control of Scer\GAL4^ey.PH or by expression of E2f1^{dsRNA.Scer\UAS.cJa} driven by Scer\GAL4^GMR.PF is weakly enhanced by combination with htt^int, whereas the eye defects observed upon expression of E(Pc)^JF03101 (under the control of either Scer\GAL4^ey.PH or Scer\GAL4^GMR.PF) are suppressed by combination with htt^int.

Combination with htt^int enhances, to a varying degree, the adult wing phenotypes induced by expression of any of the following: HDAC1^JF01401, Su(var)3-3^GD9296, Jarid2^JF02081, Su(z)12^JF01706, ash1^JF01498, trx^JF01557, brm^GD4507, Mt2^GD5033, brm^HM04019, gpp^JF01283, Rga^GL00386 or HP1b^KK108772 (controlled by Scer\GAL4^nub.PK or Scer\GAL4^en.PU) and suppresses the wing defects induced by expression of Su(var)205^KK110828, Sin3A^HMS00359 (driven by Scer\GAL4^en.PU) or Orc2^KK102852 (driven by Scer\GAL4^nub.PK).

The penetrance of the ectopic venation phenotype observed in Su(var)3-3^ΔN homozygous adults is significantly increased upon combination with htt^int.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

95538

y¹ w^67c23; htt^int/TM6B, Tb¹ y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dhtt^int

(Dietz et al., 2015)

htt^int

(Marquilly et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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