FlyBase Allele Report: Dmel\Orc2[KK102852]

General Information

Symbol

Dmel\Orc2^KK102852

Species

D. melanogaster

Name

FlyBase ID

FBal0232053

Feature type

allele

Associated gene

Dmel\Orc2

Associated Insertion(s)

Carried in Construct

P{KK102852}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102852}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102852

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

wing, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing blade, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing margin bristle, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing posterior compartment, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing vein, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of Orc2^KK102852 results in: severe small eye phenotype (with the Scer\GAL4^ey.PH driver), unfurled wings at 25[o]C and vein defects with occasional wing notches or wing margin bristle disruptions at 18[o]C (with Scer\GAL4^nub.PK), blistered or deformed posterior wing compartment (with Scer\GAL4^en.PU). Expression controlled by Scer\GAL4^Act5C.PI is lethal; has no overt adult phenotype is observed when driven by Scer\GAL4^GMR.PF.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Orc2^KK102852, Scer\GAL4^nub.PK has visible | adult stage phenotype, suppressible by htt^int

(Dietz et al., 2015)

Orc2^KK102852, Scer\GAL4^nub.PK has visible | adult stage phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Orc2^KK102852, Scer\GAL4^nub.PK has wing phenotype, suppressible by htt^int

(Dietz et al., 2015)

Orc2^KK102852, Scer\GAL4^nub.PK has wing phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The adult wing defects induced by expression of Orc2^KK102852 under the control of Scer\GAL4^nub.PK are suppressed by co-expression of htt^GD14943 or by combination with a single copy of htt^int.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107035

P{KK102852}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Orc2^KK102852

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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