FlyBase Allele Report: Dmel\trx[JF01557]

General Information

Symbol

Dmel\trx^JF01557

Species

D. melanogaster

Name

FlyBase ID

FBal0245802

Feature type

allele

Associated gene

Dmel\trx

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01557}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01557}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01557

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of congenital heart disease

CEA

(Zhu et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

increased cell death | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Oh et al., 2014)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PF

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

eye, with Scer\GAL4^GMR.PF

(Dietz et al., 2015)

haltere, with Scer\GAL4^en.PU

(Dietz et al., 2015)

posterior crossvein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing blade, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act.PU

(Oh et al., 2014)

Detailed Description

Statement

Reference

Expression of trx^JF01557 results in: small (with Scer\GAL4^ey.PH) or rough (with Scer\GAL4^GMR.PF) eye phenotype, ectopic wing material at anterior crossvein and wings bent up at the ends (with Scer\GAL4^nub.PK), pupal lethality at 25[o]C with the Scer\GAL4^en.PU driver - at 18[o]C the flies show ectopic vein at posterior crossvein and haltere transformations. Scer\GAL4^Act5C.PI-driven expression is lethal.

(Dietz et al., 2015)

Somatic clones in the third instar larval wing disc expressing trx^JF01557 under the control of Scer\GAL4^Act.PU display increased levels of cell death (visualized by an apoptotic marker, cleaved Casp3).

(Oh et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^nub.PK, trx^JF01557 has visible | adult stage phenotype, enhanceable by htt^int

(Dietz et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^nub.PK, trx^JF01557 has wing blade phenotype, enhanceable by htt^int

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The wing phenotype observed in adult flies expressing trx^JF01557 under the control of Scer\GAL4^nub.PK is enhanced by combination with htt^int.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31092

y¹ v¹; P{TRiP.JF01557}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

trx^JF01557

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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