FlyBase Allele Report: Scer\GAL4[nan.PK]

Drives expression in scolopidial neurons from late embryogenesis through adulthood, in Johnson organ neurons, in GABAergic local interneurons of the antennal lobe, and in the neurons of a number of larval, pupal and adult external sensory organs.

(FlyBase Curators, 2017)

Expression of ScerGAL4^nan.PK is seen in cell bodies found in the local interneuron cluster located lateral and dorsolateral to the antennal lobe. Most labelled cells are ipsilaterally projecting interneurons.

(Chou et al., 2010)

ScerGAL4^nan.PK drives expression in mostly GABAergic antennal lobe local interneurons, and in a subset of olfactory receptor neurons.

(Chou et al., 2010)

Reporter expression is observed in ~27-37 neurons of the third antennal segment that are arranged similarly to the basiconic sensilla. nan-expressing neurons have a single long dendrite that seems to extend into basiconic sensilla. The antennal nerve termini labelled in nan reporter lines projected into a region of the brain similar to that marked by a nompC reporter, namely the AMMC (antennal mechanosensory and motor center).

(Liu et al., 2007)

ScerGAL4^nan.PK drives expression in the scolopidial neurons in embryos and adults. In embryos, expression is visible in the dorsal, lateral and ventral chordotonal organs. In adults, ScerGAL4^nan.PK labels the ciliary outer segment of the Johnston organ neurons in the second segment of the antenna and the femoral chordotonal organ in the leg.

(Kim et al., 2003)

Marker for

Johnston organ neuron

(Lee et al., 2010, Kamikouchi et al., 2009)

Reflects expression of

nan

(Chou et al., 2010, Kwon et al., 2010, Lee et al., 2010, Kamikouchi et al., 2009, Sehadova et al., 2009, Yorozu et al., 2009, Kim et al., 2003)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception, with Ctet\tetX^TNT-LC.UAS

(Zhang et al., 2013)

abnormal behavior, with Ctet\tetX^TNT-LC.UAS

(Liu et al., 2007)

abnormal feeding behavior | adult stage, with nan^JF01240

(Jourjine et al., 2016)

abnormal feeding behavior | adult stage, with nan^JF01467

(Jourjine et al., 2016)

abnormal feeding behavior | adult stage | heat sensitive, with TrpA1^UAS.(B).cKa

(Jourjine et al., 2016)

abnormal locomotor behavior, with Ctet\tetX^TNT-LC.UAS

(Kamikouchi et al., 2009)

abnormal locomotor behavior | conditional, with hid^UAS.cYa

(Yorozu et al., 2009)

abnormal locomotor rhythm, with eys^NIG.15388R

(Sehadova et al., 2009)

abnormal locomotor rhythm, with nocte^RNAi.1.UAS

(Sehadova et al., 2009)

abnormal locomotor rhythm, with nocte^RNAi.2.UAS

(Sehadova et al., 2009)

abnormal locomotor rhythm | adult stage, with Ir25a^NIG.15627R

(Chen et al., 2015)

abnormal phototaxis, with Ctet\tetX^TNT-LC.UAS

(Kamikouchi et al., 2009)

abnormal touch response | adult stage, with Sarm^HMJ30091

(Hsu et al., 2021)

uncoordinated | adult stage, with Trpγ^KK107656

(Akitake et al., 2015)

Phenotype Manifest In

chordotonal organ, with hid^UAS.cYa

(Yorozu et al., 2009)

Detailed Description

Statement

Reference

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 30[o]C) of Scer\GAL4^nan.PK cells in adults significantly decreases water consumption, compared to controls.

(Jourjine et al., 2016)

External Data

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

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Statement

Reference

Xenogenetic Interactions