FB2024_03 , released June 25, 2024
Allele: Dmel\ktubUAS.cPa
Open Close
General Information
Symbol
Dmel\ktubUAS.cPa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Park
FlyBase ID
FBal0319125
Feature type
allele
Associated gene
Dmel\ktub
Associated Insertion(s)
Carried in Construct
M{UAS-ktub.P}
Key Links
Transgenic product class
cDNA
(Park et al., 2013)
wild_type
(Park et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Park et al., 2013)
wild_type
(Park et al., 2013)
Mutagen
in vitro construct
(Park et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-ktub.P}
Cytology
Description

UASt regulatory sequences drive expression of wild-type ktub (derived from the RE38560 cDNA).

(Park et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ktub
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      INPP5EMI02221/INPP5EMI02221 ktub1/ktub1 flies with expression of ktubScer\UAS.cPa or ktubmutB.Scer\UAS driven by Scer\GAL4nan.PK show significantly reduced amplitude of sound-evoked potentials from antennal nerves compared to ktub1/ktub1 Scer\GAL4nan.PK>ktubScer\UAS.cPa flies (similar to wild type amplitude); however, INPP5EMI02221/INPP5EMI02221 ktub1/ktub1 flies with expression of ktubmutB.Scer\UAS have a significantly increased amplitude in comparison to those with expression of ktubScer\UAS.cPa.

      (Park et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ktubUAS.cPa/Scer\GAL4nan.PK rescues ktub1

      (Park et al., 2015)

      ktubUAS.cPa/Scer\GAL4nan.PK rescues ktub1

      (Park et al., 2013)
      Comments

      Expression of ktubScer\UAS.cPa (but not ktubmutB.Scer\UAS) driven by Scer\GAL4nan.PK leads to amplitude of sound-evoked potentials from ktub1/ktub1 antennal nerves being similar to controls.

      (Park et al., 2015)

      Expression of ktubScer\UAS.cPa driven by Scer\GAL4nan.PK rescues auditory defects in ktub1/ktub1 flies.

      (Park et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ktubScer\UAS.cPa
      ktubUAS.cPa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Park
      Secondary FlyBase IDs
        References (2)