FB2024_03 , released June 25, 2024
Allele: Dmel\INPP5EMI02221
Open Close
General Information
Symbol
Dmel\INPP5EMI02221
Species
D. melanogaster
Name
FlyBase ID
FBal0247806
Feature type
allele
Associated gene
Dmel\INPP5E
Associated Insertion(s)
Mi{MIC}INPP5EMI02221
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}INPP5EMI02221
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        INPP5EMI02221/INPP5EMI02221 disrupts trafficking of a subset of ciliary proteins in chordotonal neurons. Extracellular sound-evoked potentials from INPP5EMI02221/INPP5EMI02221 antennal nerves are reduced in amplitude compared to controls.

        (Park et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        INPP5EMI02221/INPP5EMI02221 ktub1/ktub1 flies with expression of ktubScer\UAS.cPa or ktubmutB.Scer\UAS driven by Scer\GAL4nan.PK show significantly reduced amplitude of sound-evoked potentials from antennal nerves compared to ktub1/ktub1 Scer\GAL4nan.PK>ktubScer\UAS.cPa flies (similar to wild type amplitude); however, INPP5EMI02221/INPP5EMI02221 ktub1/ktub1 flies with expression of ktubmutB.Scer\UAS have a significantly increased amplitude in comparison to those with expression of ktubScer\UAS.cPa.

        (Park et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        INPP5EMI02221 is rescued by INPP5E+tCH322-17A13

        (Park et al., 2015)
        Comments

        INPP5E+tCH322-17A13 rescues the reduced amplitude of sound-evoked potentials from INPP5EMI02221/INPP5EMI02221 antennal nerves.

        (Park et al., 2015)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG10426MI02221
        (Bellen, 2010.12.6)
        INPP5EMI02221
        dInpp5eMI
        (Park et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)