FB2024_03 , released June 25, 2024
Allele: Dmel\ktubmutAB.UAS
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General Information
Symbol
Dmel\ktubmutAB.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0319128
Feature type
allele
Associated gene
Dmel\ktub
Associated Insertion(s)
Carried in Construct
M{UAS-ktub.mutAB}
Key Links
Transgenic product class
missense_variant
(Park et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Park et al., 2013)
Mutagen
in vitro construct
(Park et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-ktub.mutAB}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of ktub; sequence is changed from R23QKR to L23AAA (putative nuclear localization signal/IFT protein-binding site) and from K292LR to A292LA (putative phosphoinositide-binding domain).

(Park et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ktub
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      ktubmutAB.UAS/Scer\GAL4nan.PK fails to rescue ktub1

      (Park et al., 2013)
      Comments

      Expression of ktubmutAB.Scer\UAS driven by Scer\GAL4nan.PK fails to rescue auditory defects in ktub1/ktub1 flies.

      (Park et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ktubmutAB.Scer\UAS
      ktubmutAB.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)