FlyBase Allele Report: Dmel\nan[dy5]

General Information

Symbol

Dmel\nan^dy5

Species

D. melanogaster

Name

FlyBase ID

FBal0146992

Feature type

allele

Associated gene

Dmel\nan

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kim et al., 2003)

Progenitor genotype

P{lacW}519

(Kim et al., 2003)

Cytology

Description

Imprecise excision of P{lacW}519 has caused a deletion that removes bases -3330 to +1746 with respect to the nan start codon.

(Kim et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:14,187,677..14,192,752 [-]

Comment:

Imprecise excision of P{lacW}519 has caused a deletion that removes bases -3330 to +1746 with respect to the nan start codon.

(Kim et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception

(Karak et al., 2015, Kim et al., 2003)

abnormal behavior

(Liu et al., 2007)

abnormal feeding behavior | adult stage

(Jourjine et al., 2016)

abnormal neurophysiology

(Liu et al., 2007, Kim et al., 2003)

uncoordinated

(Kim et al., 2003)

uncoordinated (with nan^36a)

(Kim et al., 2003)

viable

(Kim et al., 2003)

viable (with nan^36a)

(Kim et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

nan^dy5 mutant adults have significantly increased water consumption, compared to controls.

(Jourjine et al., 2016)

Homozygous flies show disrupted hygrosensing behaviour; a higher fraction of flies choose moist air (100% humidity) over dry air (0% humidity) compared to wild-type controls in a hygrosensory behaviour assay after five minutes.

Mutants show an impaired electrophysiological response to dry air, while leaving moist air sensing unaffected (recordings were taken at the base of the 2nd antennal segment in these experiments).

(Liu et al., 2007)

Homozygotes and nan^dy5/nan^36a transheterozygous adults are viable but show abnormal behaviour: they are sedentary, mildly uncoordinated, more likely than wild-type flies to fall whilst climbing, and slower to right themselves after a fall. Homozygotes show a loss of sound-evoked potentials when the antennal extracellular potentials are recorded. Mutant chordotonal organs appear to have normal ultrastructure.

(Kim et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

nan^dy5 has abnormal auditory perception phenotype, suppressible | partially by Dnah3^MB05004

(Karak et al., 2015)

NOT Suppressor of

Statement

Reference

nan^dy5 is a non-suppressor of abnormal auditory perception phenotype of Dnah3^MB05004

(Karak et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

As in either mutant alone, nan^dy5 Dnah3^MB05004 double mutants entirely lack sound-evoked electrical potentials. Mechanical amplification is excessive in the double mutants, similar to Dnah3^MB05004 mutants, substantially lower than in nan^dy5 mutants alone.

(Karak et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

nan^dy5 is rescued by nan^UAS.cKa/Scer\GAL4^nan.PK

(Liu et al., 2007)

nan^dy5 is rescued by nan^UAS.cKa/Scer\GAL4^nan.PK

(Kim et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

nan^dy5

(Jourjine et al., 2016, Karak et al., 2015, Liu et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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