FlyBase Allele Report: Dmel\arm[S56F.GMR]

General Information

Symbol

Dmel\arm^S56F.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0138352

Feature type

allele

Associated gene

Dmel\arm

Associated Insertion(s)

Carried in Construct

P{GMR-arm^S56F}

Also Known As

P[GMR-arm*], arm^*, GMR-arm^*

Key Links

Transgenic product class

missense_variant

(Freeman and Bienz, 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Freeman and Bienz, 2001)

Mutagen

in vitro construct

(Freeman and Bienz, 2001)

Progenitor genotype

Carried in construct

P{GMR-arm^S56F}

Cytology

Description

GMR sequences drive expression of a 2.7kb activated form of arm (contains the amino acid replacement S56F).

(Freeman and Bienz, 2001)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

arm

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Chang et al., 2008)

increased cell death

(Freeman and Bienz, 2001)

visible

(van Tienen et al., 2017, Kennell et al., 2008, Kankel et al., 2007, Lin et al., 2003)

visible | adult stage

(Chang et al., 2008)

Phenotype Manifest In

eye

(van Tienen et al., 2017, Chang et al., 2008, Kennell et al., 2008, Kankel et al., 2007, Lin et al., 2003, Parker et al., 2002, Barker et al., 2001, Freeman and Bienz, 2001)

eye, with Scer\GAL4^GMR.PF

(Fang et al., 2006)

Detailed Description

Statement

Reference

Expression of arm^S56F.GMR results in a rough eye phenotype.

(van Tienen et al., 2017)

Expression of arm^S56F.GMR under the control of Scer\GAL4^GMR.PF causes a dramatic reduction in adult eye size.

(Chang et al., 2008)

Expression of arm^S56F.GMR results in a small eye phenotype.

(Kennell et al., 2008)

Flies carrying arm^S56F.GMR have eyes which are rough and are smaller than normal.

(Kankel et al., 2007)

Expression of arm^S56F.GMR in the developing eye results in a severe reduction in adult eye size.

(Fang et al., 2006)

Expression of arm^S56F.GMR reduces eye size dramatically.

(Lin et al., 2003)

Mutant animals have a severely reduced eyes.

(Parker et al., 2002)

Eyes are rough, slightly glazed and reduced in size.

(Barker et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

arm^S56F.GMR has visible phenotype, enhanceable by mam²/mam[+]

(Kankel et al., 2007)

arm^S56F.GMR has visible phenotype, enhanceable by mam^sAX8/mam[+]

(Kankel et al., 2007)

Suppressed by

Statement

Reference

arm^S56F.GMR has visible phenotype, suppressible by pygo[+]/pygo^S123

(van Tienen et al., 2017)

arm^S56F.GMR has visible phenotype, suppressible by lgs[+]/lgs^20F

(van Tienen et al., 2017)

arm^S56F.GMR has visible phenotype, suppressible by lgs[+]/lgs^2-8

(van Tienen et al., 2017)

Scer\GAL4^GMR.PF, arm^S56F.GMR, spen^RNAi.UAS has visible | adult stage phenotype, suppressible | partially by nito^RNAi.UAS.cCa/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has visible | adult stage phenotype, suppressible by spen^RNAi.UAS/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has abnormal size | adult stage phenotype, suppressible by spen^RNAi.UAS/Scer\GAL4^GMR.PF

(Chang et al., 2008)

Scer\GAL4^GMR.PF, arm^S56F.GMR, spen^RNAi.UAS has abnormal size | adult stage phenotype, suppressible | partially by nito^RNAi.UAS.cCa/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has visible | adult stage phenotype, suppressible by nito^RNAi.UAS.cCa/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has abnormal size | adult stage phenotype, suppressible by nito^RNAi.UAS.cCa/Scer\GAL4^GMR.PF

(Chang et al., 2008)

Scer\GAL4^GMR.PF, arm^S56F.GMR, nito^RNAi.UAS.cCa has visible | adult stage phenotype, suppressible | partially by spen^RNAi.UAS/Scer\GAL4^GMR.PF

(Chang et al., 2008)

Scer\GAL4^GMR.PF, arm^S56F.GMR, nito^RNAi.UAS.cCa has abnormal size | adult stage phenotype, suppressible | partially by spen^RNAi.UAS/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has visible phenotype, suppressible by mir-8^A2196/Scer\GAL4^GMR.PF

(Kennell et al., 2008)

arm^S56F.GMR has visible phenotype, suppressible by mir-8^A1305-2/Scer\GAL4^GMR.PF

(Kennell et al., 2008)

arm^S56F.GMR has visible phenotype, suppressible by spen^DN.UAS/Scer\GAL4^GMR.PF

(Lin et al., 2003)

arm^S56F.GMR has increased cell death phenotype, suppressible by Egfr::tor^{t4021E.hs.sev}

(Freeman and Bienz, 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

arm^S56F.GMR has eye phenotype, enhanceable by mam²/mam[+]

(Kankel et al., 2007)

arm^S56F.GMR has eye phenotype, enhanceable by mam^sAX8/mam[+]

(Kankel et al., 2007)

arm^S56F.GMR has eye phenotype, enhanceable by Egfr[+]/Egfr^f2

(Freeman and Bienz, 2001)

Suppressed by

Statement

Reference

arm^S56F.GMR has eye phenotype, suppressible by pygo[+]/pygo^S123

(van Tienen et al., 2017)

arm^S56F.GMR has eye phenotype, suppressible by lgs[+]/lgs^20F

(van Tienen et al., 2017)

arm^S56F.GMR has eye phenotype, suppressible by lgs[+]/lgs^2-8

(van Tienen et al., 2017)

Scer\GAL4^GMR.PF, arm^S56F.GMR, spen^RNAi.UAS has eye phenotype, suppressible | partially by nito^RNAi.UAS.cCa/Scer\GAL4^GMR.PF

(Chang et al., 2008)

Scer\GAL4^GMR.PF, arm^S56F.GMR, nito^RNAi.UAS.cCa has eye phenotype, suppressible | partially by spen^RNAi.UAS/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has eye phenotype, suppressible by spen^RNAi.UAS/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has eye phenotype, suppressible by nito^RNAi.UAS.cCa/Scer\GAL4^GMR.PF

(Chang et al., 2008)

arm^S56F.GMR has eye phenotype, suppressible by mir-8^A2196/Scer\GAL4^GMR.PF

(Kennell et al., 2008)

arm^S56F.GMR has eye phenotype, suppressible by mir-8^A1305-2/Scer\GAL4^GMR.PF

(Kennell et al., 2008)

arm^S56F.GMR has eye phenotype, suppressible by CtBP^GSA132/Scer\GAL4^GMR.PF

(Fang et al., 2006)

arm^S56F.GMR has eye phenotype, suppressible by Scer\GAL4^GMR.PF/CtBP^GSA396

(Fang et al., 2006)

arm^S56F.GMR has eye phenotype, suppressible by spen^DN.UAS/Scer\GAL4^GMR.PF

(Lin et al., 2003)

arm^S56F.GMR has eye phenotype, suppressible by pygo^UAS.cPa/Scer\GAL4^GMR.PF

(Parker et al., 2002)

arm^S56F.GMR has eye phenotype, suppressible by pygo^EP1076/Scer\GAL4^GMR.PF

(Parker et al., 2002)

arm^S56F.GMR has phenotype, suppressible by pygo[+]/pygo^EP1076

(Thompson et al., 2002)

arm^S56F.GMR has phenotype, suppressible by pygo[+]/pygo^S28

(Thompson et al., 2002)

arm^S56F.GMR has phenotype, suppressible by pygo[+]/pygo^S123

(Thompson et al., 2002)

arm^S56F.GMR has eye phenotype, suppressible by brm[+]/brm²

(Barker et al., 2001)

arm^S56F.GMR has eye phenotype, suppressible by mor²/mor[+]

(Barker et al., 2001)

arm^S56F.GMR has eye phenotype, suppressible by Egfr::tor^{t4021E.hs.sev}

(Freeman and Bienz, 2001)

arm^S56F.GMR has eye phenotype, suppressible by aos^Δ7

(Freeman and Bienz, 2001)

arm^S56F.GMR has eye phenotype, suppressible by pan[+]/pan²

(Barker et al., 2001, Freeman and Bienz, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

pygo^S123/+, lgs^20F/+ or lgs^2-8/+ suppresses the rough eye phenotype seen in flies expressing arm^S56F.GMR.

(van Tienen et al., 2017)

Expression of spen^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GMR.PF partially suppresses the reduction in eye size seen in flies expressing arm^S56F.GMR.

Expression of nito^{dsRNA.Scer\UAS.cCa} under the control of Scer\GAL4^GMR.PF partially suppresses the reduction in eye size seen in flies expressing arm^S56F.GMR.

Co-expression of nito^{dsRNA.Scer\UAS.cCa} and spen^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GMR.PF partially suppresses the reduction in eye size seen in flies expressing arm^S56F.GMR. The suppression is greater than is seen when either transgene is expressed alone.

(Chang et al., 2008)

Expression of mir-8^A2196 under the control of Scer\GAL4^GMR.PF suppresses the small eye phenotype seen in flies expressing arm^S56F.GMR.

Expression of mir-8^A1305-2 under the control of Scer\GAL4^GMR.PF suppresses the small eye phenotype seen in flies expressing arm^S56F.GMR.

(Kennell et al., 2008)

The mutant eye phenotype of arm^S56F.GMR flies is enhanced by mam²/+ or mam^sAX8/+.

Df(1)N-54l9/+ and N^55e11/+ each have little if any effect on the mutant eye phenotype of arm^S56F.GMR flies.

(Kankel et al., 2007)

Expression of either CtBP^GSA396 or CtBP^GSA132, under the control of Scer\GAL4^GMR.PF suppresses the eye phenotype of arm^S56F.GMR flies.

(Fang et al., 2006)

Co-expression of spen^DN.Scer\UAS suppresses the reduced eye phenotype caused by expression of arm^S56F.GMR under the control of Scer\GAL4^GMR.PF.

(Lin et al., 2003)

The addition of Egfr::tor^{t4021E.hs.sev} to arm^S56F.GMR flies suppresses the rough eye phenotype by reducing the rate of cell death in the pupal eye disc by a mean factor 3.

(Freeman and Bienz, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

arm^S56F.GMR

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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