FlyBase Allele Report: Dmel\CtBP[GSA396]

General Information

Symbol

Dmel\CtBP^GSA396

Species

D. melanogaster

Name

FlyBase ID

FBal0194801

Feature type

allele

Associated gene

Dmel\CtBP

Associated Insertion(s)

P{GSV1}CtBP^GSA396

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Fang et al., 2006)

Progenitor genotype

Associated Insertion(s)

P{GSV1}CtBP^GSA396

Cytology

Description

P{GSV1} insertion in the first intron of CtBP.

(Fang et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{GSV1}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

visible | adult stage, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

Phenotype Manifest In

adult head, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

antenna, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

eye, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

interommatidial bristle | increased number, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

ocellar bristle, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

ocellus, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

orbital bristle | increased number, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

vibrissal bristle, with Scer\GAL4^ey.PU

(Hoang et al., 2010)

Detailed Description

Statement

Reference

Expression of CtBP^GSA396 under the control of Scer\GAL4^ey.PU leads to small and rough eyes with duplications of interommatidial bristles; occasional splitting of the eye field, sometimes accompanied by formation of antennal-like structures in the cuticular field between eye domains; apparent clefts in the vertex region of the head with loss of ocelli and mispatterning of bristles; loss of vibrissae and replacement by bristles resembling orbital or vertical bristles; and extra orbital bristles surrounded by a patch of orbital-like cuticle; and in few animals loss of distal antennal structures when compared to controls.

(Hoang et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, enhanceable by eya²⁰¹⁵/eya[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, enhanceable by eya²⁰¹⁵/eya[+]

(Hoang et al., 2010)

NOT Enhanced by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, non-enhanceable by so[+]/so³

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, non-enhanceable by so[+]/so³

(Hoang et al., 2010)

Suppressed by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, suppressible | partially by dan^ems3/dan[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by dan^ems3/dan[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, suppressible | partially by danr[+]/danr^ex35

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by danr[+]/danr^ex35

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, suppressible | partially by ey[+]/ey²

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by ey[+]/ey²

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, suppressible | partially by ey[+]/ey^R

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by ey[+]/ey^R

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, suppressible | partially by dac^P/dac[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by dac^P/dac[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, suppressible | partially by Df(2L)dac-4/+

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by Df(2L)dac-4/+

(Hoang et al., 2010)

NOT suppressed by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has abnormal size | adult stage phenotype, non-suppressible by so[+]/so³

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has visible | adult stage phenotype, non-suppressible by so[+]/so³

(Hoang et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, enhanceable by eya²⁰¹⁵/eya[+]

(Hoang et al., 2010)

NOT Enhanced by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, non-enhanceable by so[+]/so³

(Hoang et al., 2010)

Suppressed by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by ey[+]/ey^R

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by dac^P/dac[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Df(2L)dac-4/+

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has interommatidial bristle | increased number phenotype, suppressible | partially by dan^ems3/dan[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by dan^ems3/dan[+]

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has interommatidial bristle | increased number phenotype, suppressible | partially by danr[+]/danr^ex35

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by danr[+]/danr^ex35

(Hoang et al., 2010)

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by ey[+]/ey²

(Hoang et al., 2010)

NOT suppressed by

Statement

Reference

CtBP^GSA396, Scer\GAL4^ey.PU has eye phenotype, non-suppressible by so[+]/so³

(Hoang et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/CtBP^GSA396 is a suppressor of eye phenotype of arm^S56F.GMR

(Fang et al., 2006)

CtBP^GSA396, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, wg^UAS.cKa

(Fang et al., 2006)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/CtBP^GSA396 is a non-suppressor of eye phenotype of hid^GMR.PG

(Fang et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of CtBP^GSA396, suppress the eye phenotype of Scer\GAL4^GMR.PF>wg^Scer\UAS.cKa flies. Expression of CtBP^GSA396 under the control of Scer\GAL4^GMR.PF also suppresses the eye phenotype of arm^S56F.GMR flies. However, expression of this transgene fails to suppress the small eye phenotype generated by W^GMR.PG.

(Fang et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CtBP^GSA396

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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