FB2024_03 , released June 25, 2024
Allele: Dmel\eyR
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General Information
Symbol
Dmel\eyR
Species
D. melanogaster
Name
Russian
FlyBase ID
FBal0003934
Feature type
allele
Associated gene
Dmel\ey
Associated Insertion(s)
flea{}eyR
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Noveen et al., 2000)
Mutagen
spontaneous
(Quiring et al., 1994)
Progenitor genotype
Associated Insertion(s)
flea{}eyR
Cytology
Description

Maps to intron preceding exon 3. The Doc insertion in ey2 and the flea insertion in eyR map within 75 bases of each other.

(Hauck et al., 1999)

flea element insertion within intron 1.

(Xu et al., 1999)

flea insertion into an eye-specific enhancer element.

(Callaerts et al., 1995)

Insertion of a flea element near the 5' end of the ey gene into a regulatory element required for expression in the eye primordia.

(Quiring et al., 1994)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eyR heterozygotes do not exhibit any size alterations or roughness in eyes when compared to control adults.

      (Hoang et al., 2010)

      eyR/eyD animals have small eyes.

      (Kronhamn et al., 2002)

      Homozygotes show 30% lethality. Eyes are reduced in size in homozygotes; 5% have eyes that are 0-25% of wild-type size, 19% have eyes that are 25-50% of wild-type size, 49% have eyes that are 50-75% of wild-type size and 27% have eyes that are 75-100% of wild-type size. Homozygotes have no overt defects in the mushroom body or central complex. 97% of eyR/eyJD flies have eyes which are 75-100% of wild-type size and 3% have eyes that are 50-75% of wild-type size. The flies have no overt defects in the mushroom body or central complex. 89% of eyR/eyD1Da flies have eyes which are 75-100% of wild-type size, 9% have eyes that are 50-75% of wild-type size, 1% have eyes that are 25-50% of wild-type size and 1% have eyes that are 0-25% of wild-type size. The flies have no overt defects in the mushroom body or central complex.

      (Callaerts et al., 2001)

      The medial lobe of the mushroom body is malformed, fused, missing or reduced in diameter in 38% of second instar larvae. The number of Kenyon cells is reduced. The diameter of the MB peduncle is not reduced. Embryonic pattern of mushroom body neuroblasts is apparently normal.

      (Noveen et al., 2000)

      Adult eyes vary in size from full to nothing, eye disc varies from rudimentary to full-sized.

      (Renfranz and Benzer, 1989)

      Eye size relative to that of wild type: .25-.50

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ey[+]/eyR is a suppressor | partially of abnormal size | adult stage phenotype of CtBPGSA396, Scer\GAL4ey.PU

      (Hoang et al., 2010)

      ey[+]/eyR is a suppressor | partially of visible | adult stage phenotype of CtBPGSA396, Scer\GAL4ey.PU

      (Hoang et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ey[+]/eyR is a suppressor | partially of eye phenotype of CtBPGSA396, Scer\GAL4ey.PU

      (Hoang et al., 2010)
      Other
      Statement
      Reference

      NICN.UAS, Scer\GAL4ey.PH, eyR has eye | ectopic phenotype

      (Kurata et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of NICN.Scer\UAS driven by Scer\GAL4ey.PH in a ey2 background, produced flies with reduced eyes. No ectopic antennae are seen.

      (Kurata et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (1)
      Stocks (10)
      Notes on Origin
      Discoverer

      Sacharov, 13th Aug. 1923.

      Separable from: toyroo.

      (Czerny et al., 1999)
      Comments
      Comments

      Sequencing of the toy gene in eyR mutants revealed a polymorphic C to T substitution in intron 5 and an insertion of the 429bp LTR of roo in intron 1.

      (Czerny et al., 1999)

      Loss of ey expression.

      (Callaerts et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eyR
      (Hayashi et al., 2022, Hoang et al., 2010)
      Name Synonyms
      Russian
      Secondary FlyBase IDs
        References (22)