FB2024_03 , released June 25, 2024
Allele: Dmel\danrex35
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General Information
Symbol
Dmel\danrex35
Species
D. melanogaster
Name
FlyBase ID
FBal0144379
Feature type
allele
Associated gene
Dmel\danr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Emerald et al., 2003)
Progenitor genotype
danrEPg35635
(Emerald et al., 2003)
Cytology
Description

Imprecise excision of the P{EPg}danrEPg35635 insertion, resulting in a deletion of 314bp of genomic DNA, including the insertion point and extending 126bp into the danr open reading frame.

(Emerald et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:25,138,045..25,138,358 [+]
Comment:

Deletion resulting from the imprecise excision of P{EPg}danrEPg35635, which removes 314bp of genomic DNA, including the insertion point and extending 126bp into the danr open reading frame.

(Emerald et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      danrex35 heterozygotes do not exhibit any size alterations or roughness in eyes when compared to control adults.

      Mosaic individuals with danrex35 clones (in Minute background), comprising most of the eye-antennal derived structures in the adult head, exhibit defects that indicate mild antenna-to-leg transformation of the distal antenna and slightly rough eyes with significantly fewer ommatidia when compared to control adults.

      (Hoang et al., 2010)

      The third antennal segment is reduced in size in homozygous flies and develops ectopic bristles. Homozygous clones result in partial transformation of the basal cylinder towards leg; it is segmented and has bracted bristles.

      (Emerald et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      danrex35 danems3 double heterozygotes do not exhibit any visible eye phenotypes as single heterozygotes or control adults.

      Mosaic animals with danems3 danrex35 double homozygous clones (in Minute background) exhibit gaps in the ommatidial array when compared to controls. While pre-morphogenetic-furrow danems3 danrex35 double homozygous clones do not exhibit any alterations in size in the third instar larval eye-antennal discs when compared to controls.

      Mosaic animals with CtBP87De-10 danems3 danrex35 triple homozygous clones (in Minute background) exhibit defects in ommatidia with a higher frequency when compared to danems3 danrex35 double homozygous clones (in Minute background).

      (Hoang et al., 2010)

      One copy of danrex35 enhances the mild transformation of the basal capsule of the arista seen in Df(3R)ss-D114.4/+ flies.

      (Emerald et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      danrex35
      (An et al., 2023, Hoang et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)