FlyBase Allele Report: Hsap\TP53[UAS.cYa]

General Information

Symbol

Hsap\TP53^UAS.cYa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Yamaguchi

FlyBase ID

FBal0104764

Feature type

allele

Associated gene

Hsap\TP53

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\TP53.Y}

Key Links

Transgenic product class

cDNA

(Yamaguchi et al., 1999)

wild_type

(Yamaguchi et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Yamaguchi et al., 1999)

wild_type

(Yamaguchi et al., 1999)

Mutagen

in vitro construct

(Yamaguchi et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Hsap\TP53.Y}

Cytology

Description

UASt regulatory sequences drive expression of a wild-type Hsap\TP53 cDNA.

(Yamaguchi et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\TP53

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell death, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

decreased occurrence of cell division | larval stage, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

increased cell death | larval stage, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

visible

(Higashiyama et al., 2002)

visible, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

Phenotype Manifest In

eye

(Higashiyama et al., 2002)

eye, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

eye disc, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

eye disc & S phase, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

eye disc posterior to the morphogenetic furrow | larval stage, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

interommatidial bristle, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

interommatidial bristle | ectopic, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

ommatidium, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

pigment cell, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

rhabdomere, with Scer\GAL4^GMR.PS

(Yamaguchi et al., 1999)

Detailed Description

Statement

Reference

Hsap\TP53^Scer\UAS.cYa results in a dosage dependent eye degeneration phenotype.

(Higashiyama et al., 2002)

Flies expressing one copy of Hsap\TP53^Scer\UAS.cYa under the control of one copy of Scer\GAL4^GMR.PS have severely abnormal eyes which are very rough in appearance. The ommatidia lack the regular hexagonal shape seen in wild-type flies and either additional or missing bristles are apparent. The phenotype is more severe if the flies are carrying two copies of Hsap\TP53^Scer\UAS.cYa; many ommatidia appear fused, rhabdomeres with irregular shapes are seen and many ommatidia lack pigment cells. In eye discs expressing one copy of Hsap\TP53^Scer\UAS.cYa under the control of one copy of Scer\GAL4^GMR.PS incorporation of BrdU in the S phase zone corresponding to the second mitotic wave is reduced compared to wild type. In eye discs expressing two copies of Hsap\TP53^Scer\UAS.cYa under the control of one copy of Scer\GAL4^GMR.PS the S phase zone corresponding to the second mitotic wave is almost abolished. There is a significant increase in cell death posterior to the furrow in these eye discs. Extensive cell death is only seen in the very posterior of the disc.

(Yamaguchi et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)S3

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)A246

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)TW137

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(1)C246

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)VA12

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)pr-A16

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)Sd77

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)M41A4

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)CA53

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)E3363

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)en28

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)en-SFX31

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)Pu-D17

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2R)or-BR6

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(1)KA9

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(3L)vin2

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(3L)VW3

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(3R)9A99

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(3R)p-XT103

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(3R)ry615

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(3R)e-N19

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(4)M101-62f

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, enhanceable by Df(2L)ast2

(Yamaguchi et al., 1999)

NOT Enhanced by

Statement

Reference

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-enhanceable by Df(3L)W10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-enhanceable by Df(3L)Cat

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-enhanceable by Df(3L)W4

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-enhanceable by Df(2R)B5

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-enhanceable by dap⁴

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-enhanceable by dap⁰⁴⁴⁵⁴

(Yamaguchi et al., 1999)

Suppressed by

Statement

Reference

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by BacA\p35^GMR.PH

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Df(2R)cn9

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Df(2R)ST1

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Df(3L)pbl-X1

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Df(3L)BK10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Df(3R)Tpl10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Df(3R)crb87-5

(Yamaguchi et al., 1999)

NOT suppressed by

Statement

Reference

Hsap\TP53^UAS.cYa has visible phenotype, non-suppressible by TER94[+]/TER94^26-8

(Higashiyama et al., 2002)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by Df(3L)W10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by Df(3L)Cat

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by Df(3L)W4

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by Df(2R)B5

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by dap⁴

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by dap⁰⁴⁴⁵⁴

(Yamaguchi et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(1)C246

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(1)C246

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)S3

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)A246

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)A246

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)TW137

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)TW137

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)VA12

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)VA12

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)pr-A16

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)pr-A16

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)Sd77

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)Sd77

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)M41A4

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)M41A4

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(1)KA9

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)CA53

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)CA53

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)E3363

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)E3363

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)en28

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)en28

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)en-SFX31

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(1)KA9

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)en-SFX31

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)Pu-D17

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)Pu-D17

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2R)or-BR6

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2R)or-BR6

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(3L)vin2

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(3L)vin2

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(3L)VW3

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(3L)VW3

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(3R)9A99

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(3R)9A99

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(3R)p-XT103

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(3R)p-XT103

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)ast2

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(3R)ry615

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(3R)ry615

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(3R)e-N19

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(3R)e-N19

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(4)M101-62f

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(4)M101-62f

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, enhanceable by Df(2L)ast2

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, enhanceable by Df(2L)S3

(Yamaguchi et al., 1999)

Suppressed by

Statement

Reference

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Df(2R)cn9

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by Df(2R)cn9

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Df(2R)ST1

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by Df(2R)ST1

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Df(3L)pbl-X1

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by Df(3L)pbl-X1

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Df(3L)BK10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by Df(3L)BK10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Df(3R)Tpl10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by Df(3R)Tpl10

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Df(3R)crb87-5

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by Df(3R)crb87-5

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by BacA\p35^GMR.PH

(Yamaguchi et al., 1999)

Hsap\TP53^UAS.cYa, Scer\GAL4^GMR.PS has ommatidium phenotype, suppressible by BacA\p35^GMR.PH

(Yamaguchi et al., 1999)

NOT suppressed by

Statement

Reference

Hsap\TP53^UAS.cYa has eye phenotype, non-suppressible by TER94[+]/TER94^26-8

(Higashiyama et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

BacA\p35^GMR.PH is a strong suppressor of the rough eye phenotype caused by expression of Hsap\TP53^Scer\UAS.cYa under the control of Scer\GAL4^GMR.PS.

(Yamaguchi et al., 1999)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\TP53^Scer\UAS.cYa

Hsap\TP53^UAS.cYa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Yamaguchi

(Yamaguchi et al., 1999)

Secondary FlyBase IDs

References (2)

Report Sections

Open Close