83C1-83C2;84B2
83C1-83C2;84B1-84B2
83C1-83C2;84B3-84B6
83C1-83C2;84B1
l(3)04696 << bk1 << kkv << ES3-1 << bk2 << l(3)84Bc
The 3R:6896253..7086599 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of Antp, which published results say is deleted. The right extent corresponds to the left end of alphaTub84B, which published results say is not deleted.
Heterozygosity for Df(3R)Tpl10 Dp(3;3)Dfdrv1 results in 1.1% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
Df(3R)Tpl10 heterozygous flies (carrying one copy of Tpl) die in the embryonic stage. Before death, the midgut turns brown (and is the first tissue to die), and tracheal development is abnormal. This is accompanied by more widespread cell death, and then the tracheae appear to break up and turn brown. Soon thereafter, the entire animal dies. These flies are also developmentally-retarded (they exhibit the embryo phenotype at a time when the wild-type would have already hatched to the first instar larval stage). Hyperoxia partially rescues Tpl aneuploids. In air no healthy embryos survive at 36 hours but, in 45% oxygen, most embryos still appear normal. After 48 hours in air, all embryos have a brown midgut amd brown tracheal phenotypes, whereas, under hyperoxia, 35% of embryos have clear tracheae after 48 hours. Similarly, under normoxia, approximately 36% of hatched larvae die at 60 hours, whereas, in 45% oxygen all larvae are viable with no obvious defects.
Df(3R)Tpl10/Dp(3;3)Dfdrv1 shows no effect on the mutant ovarian phenotype of ovoD2.
Df(3R)Tpl10/Dp(*)Tpl+ viable Df(3R)Tpl10/Df(3R)Tpl- lethal Df(3R)Tpl10/wild-type chromosome 3 lethal
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.
Shows no maternal enhancement of dpphr4.
Deficient embryos show an uninterpretable mutant midgut phenotype.
Homozygous embryos are very abnormal compared to wild-type and are twisted.
Males fertile when in combination with αTub84B7.
induced in wild-type male
Limits of break 1 from polytene analysis (FBrf0033157) Left limit of break 2 from inclusion of l(3)84Bb (FBrf0044420) Right limit of break 2 from polytene analysis (FBrf0033157)